Figure 8
Stereo representation showing the enantioselectivity towards the S-MBA substrate in the P. aeruginosa [beta]-A:PyAT active site based on the gabaculine complex and the requirement for the scissile C[alpha]-H bond to be normal to the pyridine ring of PLP. The modelled R-MBA clashes with the neighbouring residues PA Leu60 and PA Phe89.  [article HTML]