Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex

Andersen, J.L.; Schrøder, T.J.; Christensen, S.; Strandbygård, D.; Pallesen, L.T.; García-Alai, M.M.; Lindberg, S.; Langgård, M.; Eskildsen, J.C.; David, L.; Tagmose, L.; Simonsen, K.B.; Maltas, P.J.; Rønn, L.C.B.; de Jong, I.E.M.; Malik, I.J.; Egebjerg, J.; Karlsson, J.-J.; Uppalanchi, S.; Sakumudi, D.R.; Eradi, P.; Watson, S.P.; Thirup, S.

doi:10.1107/S1399004713030149

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 2
Thermodynamics of the binding of AF40431 to sortilin. (a) The raw titration data and the integrated titration curves are depicted in the upper and lower panels, respectively. The final values of the determined thermodynamic parameters are listed in the lower panel. (b) Binding signature plot listing the enthalpic (ΔH) and entropic (−TΔS) contributions to the free binding energy (ΔG).

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 70| Part 2| January 2014| Pages 451-460

doi:10.1107/S1399004713030149

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