Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design

Sprenger, J.; Svensson, B.; Hålander, J.; Carey, J.; Persson, L.; Al-Karadaghi, S.

doi:10.1107/S1399004714027011

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 3
Schematic presentation of ligand binding and interactions in the active site of PfSpdS. (a) The complex with putrescine and MTA. (b) The complex with spermidine and MTA. (c) The complex with 4MAN and dcAdoMet. (d) The complex with 4AMA and MTA. The amino-acid side chains and bound compounds are shown in stick representation (N atoms, blue; O atoms, red; C atoms, green; S atoms, yellow). Dashed lines represent potential hydrogen bonds.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 3| February 2015| Pages 484-493

doi:10.1107/S1399004714027011

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