Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding

Oganesyan, V.; Mazor, Y.; Yang, C.; Cook, K.E.; Woods, R.M.; Ferguson, A.; Bowen, M.A.; Martin, T.; Zhu, J.; Wu, H.; Dall'Acqua, W.F.

doi:10.1107/S1399004715018015

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 5
(a) Schematic representation of the domain arrangement of human FcγRI, FcγRIIIA and variants thereof. Green and blue ovals correspond to FcγRI and FcγRIIIA domains, respectively. The low-affinity FcγRIIIA/F158 allotype was used to obtain a larger affinity range when characterizing variants. (b) Binding of human IgG1 at varying concentrations to FcγR variants as measured by ELISA. Standard deviations are indicated by error bars and represent triplicate measurements within the same experiment.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 71| Part 11| October 2015| Pages 2354-2361

doi:10.1107/S1399004715018015

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