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Figure 6
Superimposition of the complex between FcγRI (green) and Fc (orange) with FcγRIIIA–Fc (blue; PDB entry 3sgj ) and FcγRIIA–Fc (magenta; PDB entry 3ry6 ) complexes. The Fc part of the FcγRIIIA–Fc and FcγRIIA–Fc complexes is not shown. All three FcγRs bind in the crevice between Fc CH2 domains and superimpose quite well with each other. However, the details of these interactions are quite different as the FcγRIIIA–Fc interface involves carbohydrates from both the receptor and the IgG1. There is no evidence for direct protein–carbohydrate interaction in the FcγRIIA–Fc complex (perhaps owing to the low resolution of the structure).

Journal logoBIOLOGICAL
ISSN: 1399-0047
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