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![[Figure 2]](cb5088fig2mag.jpg)
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Figure 2
Structure of ERK5 in complex with XMD8-92 (compound 2). ERK5 is shown in ribbon representation with the hinge region, P-loop, αC helix and activation loop coloured yellow, blue, coral and magenta, respectively. The central portion of the activation loop (amino acids 208–215) is missing from the model. XMD8-92 (compound 2) binds in the ATP-binding site and is shown as a stick model with C atoms in green. The 2mFo − DFc OMIT electron density for compound 2 is shown as a lilac mesh contoured at 1.0σ. |
![[Figure 2]](cb5088fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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