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Figure 4
Making linkages. (a) Leaving groups. Leaving groups which abandon the reducing sugar during the linkage reaction are depicted in grey. H atoms have been omitted for reasons of clarity. (b) Linkage nomenclature. A schematic representation of a glycosidic linkage [the simplified monosaccharides are unrelated to those in (a)] is shown. Atoms are referred to by their PDBCCD nomenclature, and those groups responsible for linkage nomenclature have been colour-coded: blue, the configuration of the newly linked O4 (which substitutes O1 from the leaving group) with respect to the absolute stereochemistry as determined by C6 marks the linkage stereochemistry (β); red, the order of the bond (1–4) indicates that the linkage is a glycosidic bond between C1 from the sugar on the left and O4 from the sugar on the right. If the sugar on the left was a ketose, for example D-fructose, the linkage would be signified as β2–4, as the anomeric C atom would be C2 (see Fig. 2[link]).

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ISSN: 2059-7983
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