issue contents

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983

June 2017 issue

Proceedings of the CCP-EM Spring Symposium

Guest editors: Tom Burnley and Paula da Fonseca

Early view articles

Journal cover

research papers


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The formal description of a workflow to cryo-EM structure determination in the RELION program allows standardization of procedures and on-the-fly image processing during data acquisition.

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Recent developments in electron microscopy have provided new opportunities in the field of structure-based drug design. This review looks at the challenges that remain and the future prospects for the use of electron microscopy in this area.

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This review article summarizes recent progress in our understanding of chromatin biology based on single-particle cryo-electron microscopy studies.

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The Electron Microscopy Data Bank (EMDB), the public archive for three-dimensional EM reconstructions, is an invaluable resource for obtaining a birds-eye view of trends affecting the field of cryo-EM. EMDB is growing rapidly, with almost a quarter of the entries having been released over the past year.

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A technical description of the Dynamo software package for subtomogram averaging is provided. Details are given on advanced MATLAB libraries, parallelization strategies, the use of GPUs and accessibility though the Amazon cloud computing services.
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