forthcoming articles

The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section D: Structural Biology.

See also Forthcoming articles in all IUCr journals.

Accepted 20 June 2018

Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33

We report the X-ray crystal structure of Omp33 at a resolution of 2.1 Å. The structure helps us to understand how A. baumannii OM proteins contribute to the low permeability of the cell envelope and suggests it may function as a ligand-gated channel.

Accepted 5 June 2018

Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution

The complete post-fusion core structure of the HCoV-229E spike protein was determined at 1.86 Å. Comparison of the interactions between HR1 and HR2 in different human coronaviruses reveals some differences, which should be taken into consideration when designing pan-CoVs HR2 mimic inhibitors that target HR1.

Accepted 1 June 2018

Identifying G protein-coupled receptor dimers from crystal packings

Analysis of intermolecular interactions in the crystal structures of G protein-coupled receptors showed two major types of dimers.

Accepted 28 May 2018

The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab

A high-resolution crystal structure of a pan-specific synthetic Fab selected using a phage-display system against the C-terminal domain of the nucleoprotein from the Ebola virus is reported.

Accepted 23 May 2018

Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction

The biochemical and crystallographic characterization of different Catharanthus roseus receptor kinase 1-like membrane receptors is reported as a first step to understand cell-wall sensing and signalling mechanisms in plants.

Accepted 14 May 2018

Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2

A high-resolution X-ray structure of the seventh FAS1 domain of stabilin-2 is presented. This structure provides the first insight into the structure of stabilin-2.

Accepted 14 May 2018

Introducing SEC–SANS for studies of complex self-organized biological systems

Small-angle neutron scattering is coupled with on-line size exclusion chromatography. The obtained SEC-SANS is combined with SEC-SAXS and utilized to investigate solution structures of phospholipid nanodiscs with and without membrane proteins incorporated.

Accepted 1 May 2018

A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease

The crystal structure of the complex between a substrate selected by phage display and the D25N variant of HIV-1 protease is reported at a resolution of 1.1 Å. The structure has several unprecedented features, especially the formation of additional hydrogen bonds between the enzyme and the substrate.

Accepted 1 May 2018

Engineering glycoside hydrolase stability by the introduction of zinc binding

The engineering of metal binding into a cellulase increases its temperature stability while maintaining its other catalytic properties.

Accepted 25 April 2018

The rise of neutron cryo-crystallography

The application of protein X-ray crystallography cryogenic data collection environments for neutron protein crystallography is discussed.

Accepted 27 March 2018

Predicting data quality in biological X-ray solution scattering

First-principles signal-to-noise calculations for BioSAXS have been developed and applied to evaluate the impact of energy, source brightness, window scattering and other variables on the ability to detect and distinguish protein conformational changes.

Accepted 27 March 2018

Biological small-angle neutron scattering: recent results and development

Small-angle neutron scattering (SANS) provides structural information on biological macromolecules in solution that is perfectly complementary to the information obtained by other structural biology techniques, including crystallography, nuclear magnetic resonance and electron microscopy. Compared with its sister technique SAXS (small-angle X-ray scattering), SANS allows specific and individual information to be obtained on subunits within important heterogeneous biological assemblies such as multiprotein or protein–RNA/DNA complexes as well as solubilized membrane proteins.

Accepted 27 March 2018

Cryoprotectant-free high-pressure freezing and dynamic nuclear polarization for the more sensitive detection of hydrogen in neutron protein crystallography

To improve the sensitivity of hydrogen detection using neutrons, high-pressure freezing of a relatively large protein single crystal and the proton polarization of a protein polycrystalline state were demonstrated as preliminary experiments.

Accepted 22 March 2018

Determining the amphipol distribution within membrane-protein fibre samples using small-angle neutron scattering

Using the unique ability of small-angle neutron scattering to resolve a hydrogen-rich surfactant from a deuterated membrane protein, the results of removing free surfactant from the equilibrium are revealed.

Accepted 22 March 2018

The actions of volatile anesthetics: a new perspective

Recent work applying neutron and X-ray scattering to elucidate molecular mechanisms of volatile anesthetics is reviewed

Accepted 19 March 2018

Evaluation of models determined by neutron diffraction and proposed improvements to their validation and deposition

Models of crystal structures determined by neutron diffraction deposited in the Protein Data Bank to date were analysed. Lessons learned from this data-mining effort are summarized and suggestions for improvements to the deposition and validation of neutron models are outlined.


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