forthcoming articles

The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section D: Structural Biology.

See also Forthcoming articles in all IUCr journals.

Accepted 11 December 2018

Solution structures of long-acting insulin analogues and their complexes with albumin

Solution structures of complexes between human serum albumin and the two lipidated insulin analogues, detemir and degludec are presented, and models for the equilibria are suggested.

Accepted 11 December 2018

Progress and prospects for neutron scattering in the biological sciences

A wide variety of neutron scattering techniques can be applied to obtain information on the structure and dynamics of biological systems on multiple scales. Recent progress is summarized, as are hoped-for future developments in the context of the advent of next-generation neutron sources on various continents.

Accepted 10 December 2018

A 60-Heme Reductase Complex from an Anammox Bacterium Shows an Extended Electron Transfer Pathway

Abstract The heterododecameric complex of a reducing octaheme cytochrome c with its redox partner shows an extended electron transfer pathway.

Accepted 4 December 2018

Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation

Catabolism of fatty acids in mycobacteria involves an extensively redundant set of enzymes. Here describe the structure of L-3-hy­droxy­acyl-CoA de­hydrogenase FadB2, and explore structural cues as to how it may work with other components of β-oxidation.

Accepted 30 November 2018

The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer

The N-acetyl­glucosamine 2-epimerase (AGE) from Nostoc sp. KVJ10 (nAGE10) has been crystallized in a different space group than other AGEs. The nAGE10 dimer, while different from the proposed AGE dimer in previously published structures, can be found in those and is probably the biological one.

Accepted 21 November 2018

Structural studies of a surface-entropy reduction mutant of O-GlcNAcase

The surface-entropy reduction method has been used to generate new crystal forms of the human O-GlcNAcase.

Accepted 19 November 2018

Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes

Crystal structures of the complex of a serine protease inhibitor from B. bauhinioides with bovine trypsin were determined in two crystal forms, which served as templates for modeling the structures of its complexes with plasma and tissue kallikreins.

Accepted 13 November 2018

Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment

LexA, a protein that is involved in the SOS response, from M. tuberculosis and its mutants have been biochemically characterized and the structures of their catalytic segments have been determined.

Accepted 9 November 2018

Biological Small-Angle Scattering: Theory and Practice

Biological Small-Angle Scattering: Theory and Practice by Eaton E. Lattman, Thomas D. Grant and Edward H. Snell is reviewed.

Accepted 6 November 2018

Choosing your (Friedel) mates wisely: grouping data sets to improve anomalous signal

Merging statistics are evaluated in multi crystal SAD and used to optimized the anomalous signal.

Accepted 5 November 2018

Sample delivery for serial crystallography at free-electron lasers and synchrotrons

Current developments and challenges for serial sample delivery at synchrotrons and X-ray free-electron lasers are reviewed, including the new megahertz repetition-rate machines, with an emphasis on liquid injection and high-viscosity extrusion.

Accepted 2 November 2018

Utilizing guanine-coordinated Zn2+ ions to determine DNA crystal structures by single-wavelength anomalous diffraction

Guanine N7–Zn2+ coordination served as the basis for the determination of three DNA crystal structures using zinc single-wavelength anomalous diffraction. This method is likely to be broadly applicable to the experimental determination of crystal structures of nucleic acids.

Accepted 30 October 2018

Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement

The structure of interferon-stimulated gene product 15 (ISG15) from the bat species M. davidii was elucidated to 1.37 Å resolution. Structural comparison of this ISG15 originating from a species of vesper bat endemic to China with those from mouse and human illuminates a conserved hydrophobic interface between the ubiquitin-like domains of ISG15. The importance of this interaction was probed for its influence on ISG15 engagement by a papain-like viral deISGylase using isothermal titration calorimetry.

Accepted 27 October 2018

Iron–sulfur clusters have no right angles

A set of restraints for an iron–sulfur cluster based on small-molecule structures was generated and tested in structure refinement. Additionally, the small-molecule structures also provided bond and angle restraints for linking the cluster to the coordinating cysteine residues.

Accepted 22 October 2018

Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

The X-ray structure and SAXS analysis of the C-terminal domain of the nucleocapsid from Middle East respiratory syndrome coronavirus, an emerging virus, are reported.

Accepted 21 October 2018

The structure of the AliC GH13 α-amylase from Ali­cyclobacillus sp. reveals the accommodation of starch branching points in the α-amylase family

In the light of NMR data on product profiles, the structure of an Alicyclobacillus sp. CAZy family GH13 α-amylase highlights the accommodation of branch points in the α-amylase active centre.

Accepted 17 September 2018

Resolving indexing ambiguities in XFEL diffraction patterns

Here we present an automated method that diagnoses indexing ambiguities and produces a consistent indexing choice for the large majority of diffraction images.

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