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The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section D: Structural Biology.
See also Forthcoming articles in all IUCr journals.
research papersThe third structural switch in the molecule of archaeal translation initiation factor 2 and its possible role in initiation of GTP hydrolysis and removal of aIF2 from the ribosome
The structure of aIF2γ in complex with GTPCP without Mg2+ ions in crystallization solution is determined and the new information about the role of Mg2+ ions in the function of aIF2ing is provided. The new functional region (switch 3) of the aIF2γ is discovered.
research papersConformational changes in the third PDZ domain of the neuronal postsynaptic density protein 95
Crystal structures of the third PDZ domain of the neuronal postsynaptic density protein 95 lacking the third α-helix and protein variants D332P and D332G show conformational plasticity.
research papersRefinement of protein structures using a combination of quantum-mechanical calculations with neutron and X-ray crystallographic data
We have developed a method to combine quantum mechanical calculations and joint crystallographic refinement against X-ray and neutron data. Applications to structures of the galectin-3 C–lactose complex and lytic polysaccharide monooxygenase show that it can improve the geometry for water molecules, deuterium atoms and hydrogen bonds, as well as determine protonation states of key residues.
research papersX-ray structure of an inactive zymogen clostripain-like protease from Parabacteroides distasonis
Cysteine proteases are among the most prominent hydrolytic enzymes produced by human distal gut commensal bacteria. Here, the first inactive zymogen structure of a clostripain-like C11 protease family member is reported from the bacterium P. distasonis.
research papersresearch papersIn-house high-energy-remote SAD phasing using the magic triangle: how to tackle the P1 low symmetry using multiple orientations of the same crystal of human IBA57 to increase the multiplicity
The paper describes the structure solution of human IBA57; to our knowledge, this is the only structure present in the Protein Data Bank which has been solved in-house by remote SAD phasing in space group P1 using only one crystal.
research papersresearch papersresearch papersresearch papersCoping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a
The solution of a structure of human Rab27a suffering from severe anisotropy and translational noncrystallographic symmetry was aided by identifying diffraction measurements with low information content.
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