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Acta Cryst. (2008). E64, o1517    [ doi:10.1107/S1600536808021181 ]

(3R,4S,5S)-4-Hydroxy-3-methyl-5-[(2S,3R)-3-methylpent-4-en-2-yl]tetrahydrofuran-2-one

A. Becker, M. Schürmann, H. Preut and M. Hiersemann

Abstract top

The title compound, C11H18O3, was synthesized to prove the relative configuration of the corresponding acyclic C1-C8 stereopentade. It crystallizes with two molecules in the asymmetric unit, which show only slight differences. The molecules are linked via O-H...O hydrogen bonds, resulting in two crystallographically independent chains of molecules propagating in the a-axis direction. The absolute configuration was known from the synthesis.

Comment top

The title compound, (I), was synthesized using a catalytic asymmetric Claisen rearrangement (Abraham et al., 2004a; Abraham et al. 2004b; Pollex & Hiersemann, 2005; Körner & Hiersemann, 2006; Körner & Hiersemann, 2007), a diastereoselective reduction with K-Selectride (Körner & Hiersemann, 2006; Körner & Hiersemann, 2007), and an aldol addition under modified Evans conditions (Evans et al., 1981). In order to verify the relative configuration of the major diastereomer of the obtained aldol adduct (dr = 7/3), 4-(tert-butyldimethylsilyloxy)-3-hydroxy-2,5,6-trimethyloct-7-enoyl)-4-isopropyloxazolidin-2-one, (II), a γ-lactone, (I), was prepared by removal of the silyl protecting group (Corey et al., 1972) and subsequent in situ lactonization. Fig. 1 depicts the structure of the isolated major diastereomer (I). The configuration of the chiral C atoms in (I) can be attributed to the stereochemical course of the aldol addition (C3 R and C4 S), the diastereoselective reduction with K-Selectride (C5 S), and the catalytic asymmetric Claisen rearrangement (C2 S and C3 R) using the chiral Lewis acid [Cu{(S,S)-tert-Butyl-box}](H2O)2(SbF6)2 (Evans et al., 1999).

There are two molecules of (I) in the asymmetric unit (Figs. 1 and 2) with similar conformations. In the crystal, the molecules interact via O—H···O hydrogen bonds (Table 1) to form two independent chains, both propagating in [100].

Related literature top

For related literature, see: Abraham, Körner & Hiersemann (2004); Abraham, Körner, Schwab & Hiersemann (2004); Corey & Snider (1972); Evans et al. (1981, 1999); Körner & Hiersemann (2006, 2007); Pollex & Hiersemann (2005).

Experimental top

The title compound, (I), was synthesized from the corresponding anti-aldol adduct, (II), using tetrabutylammonium fluoride (TBAF) (Corey et al., 1972) for the removal of the silyl protecting group. The subsequent lactonization proceeded in situ.

TBAF (1 M in tetrahydrofuran, 0.82 ml, 3.0 eq) was added to a solution of the diastereomeric mixture of (II) (dr = 7/3, 120 mg, 0.27 mmol, 1.0 eq) in dry tetrahydrofuran (2 ml) at 273 K. The mixture was stirred at 273 K for 15 min and then at 298 K for 30 min. The reaction was quenched by the addition of saturated aqueous NaHCO3 solution. The phases were separated, and the aqueous phase was extracted with CH2Cl2. The combined organic layers were dried over MgSO4 and concentrated under reduced pressure. Flash chromatography (isohexane/ethyl acetate 20/1 to 10/1) afforded (I) as a single diastereomer and additionally a mixture of (I) and the minor diastereomer with an overall yield of 72% (38.7 mg, 0.195 mmol) as colourless crystals. Single crystals of (I) were obtained by vapor diffusion recrystallization technique from isohexane and ethyl acetate to yield colourless cuboids: mp 412 K; Rf 0.33 (cyclohexane/ethyl acetate 2/1); 1H NMR (CDCl3, 400 MHz, δ): 0.84 (d, J = 7.0 Hz, 3H, (1)-H), 0.97 (d, J = 7.0 Hz, 3H, (3)'-H), 1.27 (d, J = 7.3 Hz, 3H, 3'-H), 1.85 (d, J = 4.8 Hz, 1H, –OH) overlapped by 1.89 (br. s), 2.19 (dqd, J = 10.6, 7.0, 3.0 Hz, 1H, (2)-H), 2.73 (dq, J = 4.8, 7.3 Hz, 1H, 3-H) overlapped by 2.62 - 2.72 (m, 1H, (3)-H), 4.07 (dd, J = 10.6, 3.0 Hz, 1H, 5-H), 4.37 (dd, J = 7.3, 4.8 Hz, 1H, 4-H), 5.03 (dd, 3J(E) = 17.0 Hz, 2J = 1.3 Hz, 1H, (5)-H), 5.04 (dd, 3J(Z) = 11.0 Hz, 2J = 1.3 Hz, 1H, (5)-H), 5.84 (ddd, 3J(E) = 17.0 Hz, 3J(Z) = 11.0 Hz, 3J = 6.3 Hz, 1H, (4)-H); 13C NMR (CDCl3, 100 MHz, δ): 8.4 (CH3), 9.7 (CH3), 12.3 (CH3), 35.7 (CH), 36.9 (CH), 42.7 (CH), 71.7 (CH), 84.3 (CH), 114.3 (CH2), 142.7 (CH), 178.4 (C); IR (cm-1): 3435(br, nm) (ν O—H, OH in H-bridges), 3085(w) 3020(w) (ν C—H, olefin), 2970(m) 2925(m) 2855(s) (νas,s C—H, CH2, CH3, CH), 1740(s) (ν C=O, lactone), 1640(w) (ν C=C), 1465(m) (δas C—H, CH3, CH2), 1380(m) (δs C—H, CH3); Anal. Calcd. for C11H18O3: C, 66.6; H, 9.2; Found: C, 66.5; H, 9.3; [α]D20 +2.2 (c 0.472, CHCl3).

Refinement top

Anomalous dispersion was negligible and Friedel pairs were merged before refinement. The H atoms were geometrically placed (C—H = 0.93-0.98Å, O—H = 0.82Å) and refined as riding with Uiso(H) = 1.2Ueq(C) or 1.5Ueq(methyl C, O).

Computing details top

Data collection: COLLECT (Nonius, 1998); cell refinement: DENZO and SCALEPACK (Otwinowski & Minor, 1997); data reduction: DENZO and SCALEPACK (Otwinowski & Minor, 1997); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL-Plus (Sheldrick, 2008); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2003).

Figures top
[Figure 1] Fig. 1. : The molecular structure of molecule one of (I), with displacement ellipsoids for the non-hydrogen atoms shown at the 30% probability level.
[Figure 2] Fig. 2. : The molecular structure of molecule two of (I), with displacement ellipsoids for the non-hydrogen atoms shown at the 30% probability level.
(3R,4S,5S)-4-Hydroxy-3-methyl-5-[(2S,3R)- 3-methylpent-4-en-2-yl]tetrahydrofuran-2-one top
Crystal data top
C11H18O3F000 = 432
Mr = 198.25Dx = 1.103 Mg m−3
Monoclinic, P21Mo Kα radiation
λ = 0.71073 Å
Hall symbol: P 2ybCell parameters from 9263 reflections
a = 6.2934 (13) Åθ = 3.0–25.4º
b = 16.411 (3) ŵ = 0.08 mm−1
c = 11.607 (2) ÅT = 291 (1) K
β = 95.46 (3)ºBlock, colourless
V = 1193.4 (4) Å30.30 × 0.28 × 0.20 mm
Z = 4
Data collection top
Nonius KappaCCD
diffractometer		2268 independent reflections
Radiation source: fine-focus sealed tube1228 reflections with I > 2σ(I)
Monochromator: graphiteRint = 0.026
Detector resolution: 19 vertical, 18 horizontal pixels mm-1θmax = 25.4º
T = 291(1) Kθmin = 3.0º
259 frames via ω–rotation (Δω=1%) and two times 120 s per frame (three sets at different κ–angles) scansh = −7→7
Absorption correction: nonek = −19→19
9263 measured reflectionsl = −13→13
Refinement top
Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.036H-atom parameters constrained
wR(F2) = 0.080  w = 1/[σ2(Fo2) + (0.0276P)2]
where P = (Fo2 + 2Fc2)/3
S = 1.06(Δ/σ)max = 0.001
2268 reflectionsΔρmax = 0.14 e Å−3
262 parametersΔρmin = −0.10 e Å−3
1 restraintExtinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methodsExtinction coefficient: 0.042 (4)
Crystal data top
C11H18O3V = 1193.4 (4) Å3
Mr = 198.25Z = 4
Monoclinic, P21Mo Kα
a = 6.2934 (13) ŵ = 0.08 mm−1
b = 16.411 (3) ÅT = 291 (1) K
c = 11.607 (2) Å0.30 × 0.28 × 0.20 mm
β = 95.46 (3)º
Data collection top
Nonius KappaCCD
diffractometer		2268 independent reflections
Absorption correction: none1228 reflections with I > 2σ(I)
9263 measured reflectionsRint = 0.026
Refinement top
R[F2 > 2σ(F2)] = 0.036H-atom parameters constrained
wR(F2) = 0.080Δρmax = 0.14 e Å−3
S = 1.06Δρmin = −0.10 e Å−3
2268 reflectionsAbsolute structure: ?
262 parametersFlack parameter: ?
1 restraintRogers parameter: ?
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
O1−0.2547 (2)0.96841 (13)0.63254 (16)0.0723 (6)
O20.1616 (3)0.91394 (14)0.55403 (19)0.0818 (7)
H20.27470.91600.52450.123*
O3−0.4523 (3)0.95694 (15)0.46477 (16)0.0804 (6)
C10.0831 (4)0.99366 (19)0.5670 (2)0.0699 (9)
H10.19791.03420.57000.084*
C2−0.0400 (4)0.9980 (2)0.6745 (2)0.0717 (9)
H2A−0.05121.05520.69710.086*
C3−0.2854 (5)0.9770 (2)0.5177 (3)0.0677 (8)
C4−0.0916 (4)1.0127 (2)0.4718 (2)0.0713 (9)
H4−0.11011.07200.47000.086*
C5−0.0562 (5)0.9858 (2)0.3503 (2)0.0963 (11)
H5A−0.02720.92840.35010.144*
H5B0.06291.01490.32460.144*
H5C−0.18180.99710.29920.144*
C60.0466 (4)0.9499 (2)0.7790 (2)0.0766 (9)
H60.06360.89340.75410.092*
C70.2689 (5)0.9825 (2)0.8203 (3)0.0999 (12)
H7A0.36680.96870.76470.150*
H7B0.31650.95850.89360.150*
H7C0.26281.04060.82830.150*
C8−0.1058 (5)0.9493 (3)0.8754 (3)0.0969 (12)
H8−0.24410.92990.83970.116*
C9−0.1446 (7)1.0344 (3)0.9243 (3)0.1352 (16)
H9A−0.24591.03060.98090.203*
H9B−0.19951.06980.86260.203*
H9C−0.01251.05600.95980.203*
C10−0.0295 (7)0.8869 (4)0.9651 (4)0.146 (2)
H100.00900.83780.93270.175*
C11−0.0089 (10)0.8863 (6)1.0604 (6)0.278 (5)
H11A−0.04280.93231.10170.333*
H11B0.04220.83981.09950.333*
O1'−0.6701 (3)0.71545 (13)0.46394 (18)0.0769 (6)
O2'−0.2446 (3)0.67928 (15)0.3828 (2)0.0935 (7)
H2'−0.13590.68680.35050.140*
O3'−0.8637 (4)0.71727 (16)0.29367 (18)0.0963 (8)
C1'−0.3349 (5)0.7549 (2)0.4080 (3)0.0777 (9)
H1'−0.22550.79740.42030.093*
C2'−0.4615 (4)0.7458 (2)0.5138 (3)0.0727 (9)
H2'1−0.48160.80000.54650.087*
C3'−0.7005 (5)0.7353 (2)0.3510 (3)0.0794 (10)
C4'−0.5091 (5)0.7794 (2)0.3145 (3)0.0839 (10)
H4'−0.53470.83790.32320.101*
C5'−0.4680 (6)0.7646 (3)0.1898 (3)0.1211 (15)
H5'1−0.34270.79400.17300.182*
H5'2−0.58830.78310.13960.182*
H5'3−0.44680.70740.17790.182*
C6'−0.3719 (4)0.6903 (2)0.6094 (3)0.0726 (9)
H6'−0.35150.63670.57490.087*
C7'−0.1534 (5)0.7211 (2)0.6567 (3)0.0986 (12)
H7'1−0.05660.71690.59780.148*
H7'2−0.10130.68880.72240.148*
H7'3−0.16420.77700.67970.148*
C8'−0.5233 (5)0.6788 (2)0.7046 (3)0.0773 (9)
H8'−0.66090.66230.66470.093*
C9'−0.5664 (6)0.7563 (3)0.7697 (3)0.1204 (14)
H9'1−0.43540.77600.80910.181*
H9'2−0.66640.74500.82520.181*
H9'3−0.62480.79680.71610.181*
C10'−0.4516 (6)0.6101 (3)0.7795 (4)0.1110 (13)
H10'−0.43280.56140.74080.133*
C11'−0.4126 (8)0.6067 (4)0.8851 (4)0.183 (3)
H11C−0.42760.65300.93000.220*
H11D−0.36790.55790.92030.220*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
O10.0470 (10)0.0854 (17)0.0864 (13)−0.0022 (11)0.0168 (9)0.0018 (13)
O20.0649 (13)0.0683 (17)0.1164 (16)0.0050 (11)0.0310 (12)0.0017 (13)
O30.0569 (12)0.0926 (18)0.0930 (13)−0.0018 (13)0.0134 (11)0.0007 (13)
C10.0543 (17)0.052 (2)0.106 (2)−0.0006 (16)0.0204 (16)−0.0009 (18)
C20.0513 (16)0.072 (3)0.094 (2)−0.0065 (16)0.0167 (15)−0.0091 (19)
C30.0549 (18)0.063 (2)0.088 (2)0.0086 (17)0.0190 (16)0.0012 (19)
C40.0609 (18)0.065 (2)0.090 (2)0.0004 (16)0.0210 (16)0.0089 (17)
C50.083 (2)0.112 (3)0.099 (2)−0.003 (2)0.0322 (17)0.004 (2)
C60.0509 (16)0.091 (3)0.0888 (19)−0.0027 (17)0.0115 (15)−0.007 (2)
C70.0603 (18)0.125 (4)0.115 (2)−0.008 (2)0.0097 (16)−0.012 (2)
C80.0648 (19)0.140 (4)0.087 (2)−0.003 (2)0.0156 (18)−0.007 (3)
C90.111 (3)0.173 (5)0.128 (3)0.024 (3)0.047 (3)−0.021 (3)
C100.106 (3)0.249 (7)0.086 (3)0.007 (4)0.027 (3)0.030 (4)
C110.147 (5)0.476 (16)0.222 (7)0.051 (7)0.075 (6)0.165 (9)
O1'0.0496 (11)0.0897 (18)0.0938 (14)−0.0022 (11)0.0186 (10)0.0066 (12)
O2'0.0718 (14)0.0719 (18)0.1435 (19)0.0044 (13)0.0446 (13)0.0045 (15)
O3'0.0646 (14)0.125 (2)0.1002 (15)−0.0110 (15)0.0131 (12)0.0065 (14)
C1'0.0634 (19)0.056 (2)0.117 (2)−0.0012 (17)0.0241 (19)0.003 (2)
C2'0.0534 (18)0.060 (2)0.106 (2)−0.0041 (16)0.0122 (16)−0.003 (2)
C3'0.060 (2)0.086 (3)0.095 (2)0.0041 (19)0.0236 (18)0.006 (2)
C4'0.073 (2)0.069 (3)0.112 (2)−0.0002 (18)0.0255 (19)0.011 (2)
C5'0.103 (3)0.153 (4)0.114 (3)−0.008 (3)0.045 (2)0.016 (3)
C6'0.0542 (17)0.064 (2)0.101 (2)0.0017 (16)0.0160 (16)−0.005 (2)
C7'0.0560 (18)0.097 (3)0.142 (3)−0.0047 (19)0.0043 (18)−0.004 (2)
C8'0.0616 (18)0.079 (3)0.092 (2)0.0030 (18)0.0084 (16)0.002 (2)
C9'0.107 (3)0.128 (4)0.128 (3)0.021 (3)0.019 (2)−0.026 (3)
C10'0.078 (2)0.149 (4)0.108 (3)0.001 (3)0.020 (2)0.015 (3)
C11'0.134 (4)0.252 (7)0.161 (4)0.028 (4)−0.001 (4)0.069 (5)
Geometric parameters (Å, °) top
O1—C31.336 (3)O1'—C3'1.347 (3)
O1—C21.474 (3)O1'—C2'1.470 (3)
O2—C11.411 (3)O2'—C1'1.408 (4)
O2—H20.8200O2'—H2'0.8200
O3—C31.211 (3)O3'—C3'1.206 (3)
C1—C41.515 (4)C1'—C4'1.521 (4)
C1—C21.532 (4)C1'—C2'1.533 (4)
C1—H10.9800C1'—H1'0.9800
C2—C61.504 (4)C2'—C6'1.503 (4)
C2—H2A0.9800C2'—H2'10.9800
C3—C41.496 (4)C3'—C4'1.500 (5)
C4—C51.515 (4)C4'—C5'1.514 (4)
C4—H40.9800C4'—H4'0.9800
C5—H5A0.9600C5'—H5'10.9600
C5—H5B0.9600C5'—H5'20.9600
C5—H5C0.9600C5'—H5'30.9600
C6—C71.531 (4)C6'—C7'1.517 (4)
C6—C81.542 (4)C6'—C8'1.538 (4)
C6—H60.9800C6'—H6'0.9800
C7—H7A0.9600C7'—H7'10.9600
C7—H7B0.9600C7'—H7'20.9600
C7—H7C0.9600C7'—H7'30.9600
C8—C101.506 (7)C8'—C10'1.469 (6)
C8—C91.536 (6)C8'—C9'1.516 (5)
C8—H80.9800C8'—H8'0.9800
C9—H9A0.9600C9'—H9'10.9600
C9—H9B0.9600C9'—H9'20.9600
C9—H9C0.9600C9'—H9'30.9600
C10—C111.102 (6)C10'—C11'1.228 (5)
C10—H100.9300C10'—H10'0.9300
C11—H11A0.9300C11'—H11C0.9300
C11—H11B0.9300C11'—H11D0.9300
C3—O1—C2109.6 (2)C3'—O1'—C2'109.9 (2)
C1—O2—H2109.5C1'—O2'—H2'109.5
O2—C1—C4110.5 (3)O2'—C1'—C4'111.2 (3)
O2—C1—C2109.8 (2)O2'—C1'—C2'109.3 (3)
C4—C1—C2101.3 (2)C4'—C1'—C2'101.7 (2)
O2—C1—H1111.6O2'—C1'—H1'111.4
C4—C1—H1111.6C4'—C1'—H1'111.4
C2—C1—H1111.6C2'—C1'—H1'111.4
O1—C2—C6110.1 (2)O1'—C2'—C6'110.1 (2)
O1—C2—C1103.6 (2)O1'—C2'—C1'103.3 (2)
C6—C2—C1117.4 (2)C6'—C2'—C1'117.6 (2)
O1—C2—H2A108.5O1'—C2'—H2'1108.5
C6—C2—H2A108.5C6'—C2'—H2'1108.5
C1—C2—H2A108.5C1'—C2'—H2'1108.5
O3—C3—O1120.9 (2)O3'—C3'—O1'120.8 (3)
O3—C3—C4128.5 (3)O3'—C3'—C4'128.8 (3)
O1—C3—C4110.6 (3)O1'—C3'—C4'110.4 (3)
C3—C4—C5114.5 (3)C3'—C4'—C5'114.1 (3)
C3—C4—C1102.7 (2)C3'—C4'—C1'102.4 (3)
C5—C4—C1117.3 (2)C5'—C4'—C1'117.5 (3)
C3—C4—H4107.3C3'—C4'—H4'107.4
C5—C4—H4107.3C5'—C4'—H4'107.4
C1—C4—H4107.3C1'—C4'—H4'107.4
C4—C5—H5A109.5C4'—C5'—H5'1109.5
C4—C5—H5B109.5C4'—C5'—H5'2109.5
H5A—C5—H5B109.5H5'1—C5'—H5'2109.5
C4—C5—H5C109.5C4'—C5'—H5'3109.5
H5A—C5—H5C109.5H5'1—C5'—H5'3109.5
H5B—C5—H5C109.5H5'2—C5'—H5'3109.5
C2—C6—C7108.6 (3)C2'—C6'—C7'109.2 (3)
C2—C6—C8112.7 (3)C2'—C6'—C8'113.0 (2)
C7—C6—C8112.9 (2)C7'—C6'—C8'112.5 (3)
C2—C6—H6107.5C2'—C6'—H6'107.3
C7—C6—H6107.5C7'—C6'—H6'107.3
C8—C6—H6107.5C8'—C6'—H6'107.3
C6—C7—H7A109.5C6'—C7'—H7'1109.5
C6—C7—H7B109.5C6'—C7'—H7'2109.5
H7A—C7—H7B109.5H7'1—C7'—H7'2109.5
C6—C7—H7C109.5C6'—C7'—H7'3109.5
H7A—C7—H7C109.5H7'1—C7'—H7'3109.5
H7B—C7—H7C109.5H7'2—C7'—H7'3109.5
C10—C8—C9114.5 (3)C10'—C8'—C9'114.0 (3)
C10—C8—C6109.1 (3)C10'—C8'—C6'110.1 (3)
C9—C8—C6113.1 (3)C9'—C8'—C6'114.1 (3)
C10—C8—H8106.5C10'—C8'—H8'106.0
C9—C8—H8106.5C9'—C8'—H8'106.0
C6—C8—H8106.5C6'—C8'—H8'106.0
C8—C9—H9A109.5C8'—C9'—H9'1109.5
C8—C9—H9B109.5C8'—C9'—H9'2109.5
H9A—C9—H9B109.5H9'1—C9'—H9'2109.5
C8—C9—H9C109.5C8'—C9'—H9'3109.5
H9A—C9—H9C109.5H9'1—C9'—H9'3109.5
H9B—C9—H9C109.5H9'2—C9'—H9'3109.5
C11—C10—C8134.4 (8)C11'—C10'—C8'130.3 (5)
C11—C10—H10112.8C11'—C10'—H10'114.9
C8—C10—H10112.8C8'—C10'—H10'114.9
C10—C11—H11A120.0C10'—C11'—H11C120.0
C10—C11—H11B120.0C10'—C11'—H11D120.0
H11A—C11—H11B120.0H11C—C11'—H11D120.0
C3—O1—C2—C6−148.1 (3)C3'—O1'—C2'—C6'−149.0 (3)
C3—O1—C2—C1−21.8 (3)C3'—O1'—C2'—C1'−22.6 (3)
O2—C1—C2—O1−83.7 (3)O2'—C1'—C2'—O1'−84.1 (3)
C4—C1—C2—O133.2 (3)C4'—C1'—C2'—O1'33.5 (3)
O2—C1—C2—C637.9 (3)O2'—C1'—C2'—C6'37.4 (4)
C4—C1—C2—C6154.7 (3)C4'—C1'—C2'—C6'155.1 (3)
C2—O1—C3—O3−179.6 (3)C2'—O1'—C3'—O3'−178.9 (3)
C2—O1—C3—C40.5 (3)C2'—O1'—C3'—C4'1.6 (3)
O3—C3—C4—C5−30.6 (5)O3'—C3'—C4'—C5'−31.2 (6)
O1—C3—C4—C5149.3 (3)O1'—C3'—C4'—C5'148.3 (3)
O3—C3—C4—C1−158.8 (3)O3'—C3'—C4'—C1'−159.3 (4)
O1—C3—C4—C121.1 (3)O1'—C3'—C4'—C1'20.2 (4)
O2—C1—C4—C384.0 (3)O2'—C1'—C4'—C3'84.1 (3)
C2—C1—C4—C3−32.4 (3)C2'—C1'—C4'—C3'−32.2 (3)
O2—C1—C4—C5−42.5 (4)O2'—C1'—C4'—C5'−41.7 (4)
C2—C1—C4—C5−158.9 (3)C2'—C1'—C4'—C5'−158.0 (3)
O1—C2—C6—C7−179.8 (2)O1'—C2'—C6'—C7'178.0 (2)
C1—C2—C6—C762.1 (4)C1'—C2'—C6'—C7'60.1 (4)
O1—C2—C6—C8−54.0 (4)O1'—C2'—C6'—C8'−56.0 (4)
C1—C2—C6—C8−172.1 (3)C1'—C2'—C6'—C8'−173.9 (3)
C2—C6—C8—C10168.6 (3)C2'—C6'—C8'—C10'166.5 (3)
C7—C6—C8—C10−67.9 (5)C7'—C6'—C8'—C10'−69.3 (4)
C2—C6—C8—C9−62.7 (4)C2'—C6'—C8'—C9'−63.8 (4)
C7—C6—C8—C960.8 (4)C7'—C6'—C8'—C9'60.4 (4)
C9—C8—C10—C117.2 (9)C9'—C8'—C10'—C11'−3.6 (7)
C6—C8—C10—C11135.1 (8)C6'—C8'—C10'—C11'126.1 (5)
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
O2—H2···O3i0.822.032.821 (3)163
O2'—H2'···O3'i0.821.962.771 (3)171
Symmetry codes: (i) x+1, y, z.
Table 1
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
O2—H2···O3i0.822.032.821 (3)163
O2'—H2'···O3'i0.821.962.771 (3)171
Symmetry codes: (i) x+1, y, z.
references
References top

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