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Acta Cryst. (2008). E64, o1761    [ doi:10.1107/S1600536808025786 ]

2-Methyl-3-phenylsulfonyl-5-propyl-1-benzofuran

H. D. Choi, P. J. Seo, B. W. Son and U. Lee

Abstract top

The title compound, C18H18O3S, was prepared by the oxidation of 2-methyl-3-phenylsulfanyl-5-propyl-1-benzofuran with 3-chloroperoxybenzoic acid. The phenyl ring makes a dihedral angle of 81.74 (6)° with the plane of the benzofuran fragment. The crystal structure is stabilized by C-H...[pi] interactions between a methyl H atom and the phenyl ring of the phenylsulfonyl substituent from a neighbouring molecule, and by intermolecular C-H...O interactions.

Comment top

This work is related to our communications on the synthesis and structure of 2-methyl-3-phenylsulfonyl-1-benzofuran analogues, viz. 5-ethyl-2-methyl-3-phenylsulfonyl-1-benzofuran (Choi et al., 2008a) and 5-isopropyl-2-methyl-3-phenylsulfonyl-1-benzofuran (Choi et al., 2008b). Here we report the crystal structure of the title compound, 2-methyl-3-phenylsulfonyl-5-propyl-1-benzofuran (Fig. 1).

The benzofuran unit is almost planar, with a mean deviation of 0.018 (2) Å from the least-squares plane defined by the nine constituent atoms. The phenyl ring (C9–C14) makes a dihedral angle of 81.74 (6)° with the plane of the benzofuran fragment. The crystal packing (Fig. 2) is stabilized by intermolecular C—H···π interactions between a methyl H atom and the phenyl ring of the phenylsulfonyl substituent, with a C18—H18C···Cgii separation of 3.291 (4) Å (Fig. 2 and Table 1; Cg is the centroid of the C9–C14 phenyl ring, symmetry code as in Fig. 2). The molecular packing is further stabilized by intermolecular C—H···O interactions (Fig. 2 and Table 1; symmetry code as in Fig. 2).

Related literature top

For the crystal structures of similar 2-methyl-3-phenylsulfonyl-1-benzofuran compounds, see: Choi et al. (2008a,b).

Experimental top

77% 3-Chloroperoxybenzoic acid (471 mg, 2.1 mmol) was added in small portions to a stirred solution of 2-methyl-3-phenylsulfanyl-5-propyl-1-benzofuran (282 mg, 1.0 mmol) in dichloromethane (30 ml) at 273 K. After being stirred for 4 h at room temperature, the mixture was washed with saturated sodium bicarbonate solution and the organic layer was separated, dried over magnesium sulfate, filtered and concentrated under vacuum. The residue was purified by column chromatography (hexane-ethyl acetate, 2:1 v/v) to afford the title compound as a colorless solid [yield 83%, m.p. 388–389 K; Rf = 0.75 (hexane–ethyl acetate, 2:1 v/v)]. Single crystals suitable for X-ray diffraction were prepared by evaporation of a solution of the title compound in acetone at room temperature. Spectroscopic analysis: 1H NMR (CDCl3, 400 MHz) δ 0.94 (t, J = 7.32 Hz, 3H), 1.62–1.69 (m, 2H), 2,68 (t,J = 7.32 Hz, 2H), 2.79 (s, 3H), 7.12 (d, J = 8.44 Hz, 1H), 7.31 (d, J = 8.44 Hz, 1H), 7.48–7.60 (m, 3H), 7.67 (s, 1H), 8.01 (d, J = 8.44 Hz, 2H); EI-MS 314 [M+].

Refinement top

All H atoms were positioned geometrically and refined using a riding model, with C—H = 0.95 Å for aromatic H atoms, 0.99 Å for the methylene H atoms, and 0.98 Å for methyl H atoms, respectively, and with Uiso(H) = 1.2Ueq(C) for aromatic and methylene H atoms, and Uiso(H) = 1.5Ueq(C) for methyl H atoms.

Computing details top

Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2001); data reduction: SAINT (Bruker, 2001); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997) and DIAMOND (Brandenburg, 1998); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. The molecular structure of the title compound, showing displacement ellipsoids drawn at the 50% probability level.
[Figure 2] Fig. 2. C—H···π and C—H···O interactions (dotted lines) in the title compound. Cg denotes the ring centroid. [Symmetry code: (i) x + 1, y, z; (ii) x + 1/2, -y + 3/2, 1/2 + z+1/2; (iii) x - 1, y, z; (iv) x - 1/2, -y + 3/2, z + 1/2.]
2-Methyl-3-phenylsulfonyl-5-propyl-1-benzofuran top
Crystal data top
C18H18O3SF000 = 664
Mr = 314.38Dx = 1.309 Mg m−3
Monoclinic, P21/nMo Kα radiation
λ = 0.71073 Å
Hall symbol: -P_2ynCell parameters from 3769 reflections
a = 7.2712 (9) Åθ = 2.4–28.3º
b = 17.583 (2) ŵ = 0.21 mm−1
c = 12.788 (2) ÅT = 173 (2) K
β = 102.669 (2)ºBlock, colourless
V = 1595.1 (4) Å30.40 × 0.40 × 0.30 mm
Z = 4
Data collection top
Bruker SMART CCD
diffractometer		3125 independent reflections
Radiation source: fine-focus sealed tube2606 reflections with I > 2σ(I)
Monochromator: graphiteRint = 0.053
Detector resolution: 10.0 pixels mm-1θmax = 26.0º
T = 173(2) Kθmin = 2.0º
φ and ω scansh = −8→5
Absorption correction: nonek = −21→21
8966 measured reflectionsl = −13→15
Refinement top
Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.045H-atom parameters constrained
wR(F2) = 0.135  w = 1/[σ2(Fo2) + (0.0731P)2 + 0.5558P]
where P = (Fo2 + 2Fc2)/3
S = 1.12(Δ/σ)max = 0.001
3125 reflectionsΔρmax = 0.36 e Å−3
200 parametersΔρmin = −0.37 e Å−3
Primary atom site location: structure-invariant direct methodsExtinction correction: none
Crystal data top
C18H18O3SV = 1595.1 (4) Å3
Mr = 314.38Z = 4
Monoclinic, P21/nMo Kα
a = 7.2712 (9) ŵ = 0.21 mm−1
b = 17.583 (2) ÅT = 173 (2) K
c = 12.788 (2) Å0.40 × 0.40 × 0.30 mm
β = 102.669 (2)º
Data collection top
Bruker SMART CCD
diffractometer		3125 independent reflections
Absorption correction: none2606 reflections with I > 2σ(I)
8966 measured reflectionsRint = 0.053
Refinement top
R[F2 > 2σ(F2)] = 0.045200 parameters
wR(F2) = 0.135H-atom parameters constrained
S = 1.12Δρmax = 0.36 e Å−3
3125 reflectionsΔρmin = −0.37 e Å−3
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
S0.61553 (7)0.71791 (3)0.30885 (4)0.02750 (18)
O10.7452 (2)0.52071 (8)0.44838 (12)0.0335 (4)
O20.7324 (2)0.76700 (8)0.38556 (12)0.0367 (4)
O30.4196 (2)0.73668 (9)0.27128 (12)0.0359 (4)
C10.6276 (3)0.62641 (11)0.36076 (15)0.0258 (4)
C20.4937 (3)0.56569 (11)0.32516 (16)0.0266 (4)
C30.3214 (3)0.55783 (13)0.25182 (16)0.0310 (5)
H30.26250.60070.21310.037*
C40.2374 (3)0.48657 (13)0.23632 (17)0.0347 (5)
C50.3257 (3)0.42403 (13)0.29533 (19)0.0403 (6)
H50.26690.37560.28390.048*
C60.4948 (3)0.43051 (12)0.36937 (19)0.0380 (5)
H60.55280.38800.40940.046*
C70.5749 (3)0.50211 (12)0.38205 (16)0.0300 (5)
C80.7750 (3)0.59641 (12)0.43314 (16)0.0304 (5)
C90.7172 (3)0.71003 (11)0.19608 (16)0.0276 (4)
C100.6070 (3)0.68438 (12)0.09947 (17)0.0327 (5)
H100.47810.67170.09390.039*
C110.6880 (4)0.67762 (13)0.01194 (18)0.0403 (6)
H110.61440.6603−0.05460.048*
C120.8757 (4)0.69593 (13)0.0204 (2)0.0407 (6)
H120.93040.6910−0.04020.049*
C130.9842 (3)0.72143 (13)0.1167 (2)0.0393 (5)
H131.11290.73410.12180.047*
C140.9063 (3)0.72851 (12)0.20576 (18)0.0339 (5)
H140.98040.74570.27220.041*
C150.0537 (3)0.47675 (16)0.1550 (2)0.0445 (6)
H15A0.04730.51580.09860.053*
H15B0.05490.42640.12050.053*
C16−0.1198 (4)0.4823 (2)0.1979 (2)0.0575 (8)
H16A−0.12510.53340.22960.069*
H16B−0.11290.44440.25580.069*
C17−0.2983 (3)0.46938 (15)0.1141 (2)0.0463 (6)
H17A−0.29570.41850.08330.056*
H17B−0.30800.50760.05730.056*
H17C−0.40740.47370.14720.056*
C180.9566 (3)0.62697 (14)0.4949 (2)0.0458 (6)
H18A1.05960.60870.46330.069*
H18B0.97700.60970.56950.069*
H18C0.95320.68270.49290.069*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
S0.0294 (3)0.0218 (3)0.0307 (3)0.00328 (19)0.0053 (2)−0.00131 (19)
O10.0344 (8)0.0271 (7)0.0364 (8)0.0002 (6)0.0022 (6)0.0050 (6)
O20.0446 (9)0.0263 (7)0.0377 (8)−0.0017 (7)0.0059 (7)−0.0062 (6)
O30.0323 (9)0.0338 (8)0.0409 (9)0.0094 (7)0.0069 (7)0.0003 (7)
C10.0277 (10)0.0236 (9)0.0264 (10)0.0004 (8)0.0063 (8)−0.0003 (8)
C20.0277 (10)0.0266 (10)0.0274 (10)−0.0005 (8)0.0099 (8)−0.0029 (8)
C30.0278 (11)0.0360 (11)0.0302 (11)0.0009 (9)0.0088 (8)−0.0021 (9)
C40.0314 (12)0.0418 (12)0.0340 (11)−0.0063 (9)0.0143 (9)−0.0110 (9)
C50.0435 (14)0.0326 (11)0.0490 (14)−0.0125 (10)0.0193 (11)−0.0104 (10)
C60.0452 (14)0.0271 (11)0.0440 (13)−0.0023 (10)0.0148 (11)0.0019 (9)
C70.0314 (11)0.0293 (10)0.0302 (10)−0.0010 (8)0.0088 (9)−0.0002 (8)
C80.0327 (11)0.0259 (10)0.0312 (10)0.0002 (9)0.0042 (9)0.0008 (8)
C90.0314 (11)0.0202 (9)0.0309 (11)0.0037 (8)0.0065 (8)0.0043 (8)
C100.0315 (11)0.0325 (11)0.0327 (11)−0.0003 (9)0.0040 (9)0.0041 (9)
C110.0518 (15)0.0368 (12)0.0314 (11)−0.0026 (11)0.0074 (10)0.0025 (9)
C120.0534 (15)0.0316 (11)0.0427 (13)0.0031 (11)0.0228 (11)0.0062 (10)
C130.0343 (12)0.0323 (11)0.0545 (14)0.0007 (9)0.0165 (11)0.0067 (10)
C140.0324 (12)0.0280 (10)0.0399 (12)−0.0006 (9)0.0045 (9)0.0018 (9)
C150.0374 (13)0.0589 (15)0.0392 (13)−0.0113 (11)0.0130 (10)−0.0187 (11)
C160.0352 (14)0.096 (2)0.0409 (14)0.0089 (14)0.0068 (11)−0.0107 (14)
C170.0322 (13)0.0517 (15)0.0532 (15)0.0029 (11)0.0057 (11)−0.0032 (12)
C180.0391 (13)0.0368 (12)0.0523 (14)−0.0034 (10)−0.0103 (11)0.0062 (11)
Geometric parameters (Å, °) top
S—O21.437 (2)C10—C111.380 (3)
S—O31.438 (2)C10—H100.9500
S—C11.735 (2)C11—C121.384 (4)
S—C91.765 (2)C11—H110.9500
O1—C81.369 (2)C12—C131.384 (4)
O1—C71.378 (3)C12—H120.9500
C1—C81.360 (3)C13—C141.384 (3)
C1—C21.449 (3)C13—H130.9500
C2—C71.392 (3)C14—H140.9500
C2—C31.398 (3)C15—C161.485 (4)
C3—C41.389 (3)C15—H15A0.9900
C3—H30.9500C15—H15B0.9900
C4—C51.407 (3)C16—C171.508 (3)
C4—C151.512 (3)C16—H16A0.9900
C5—C61.382 (3)C16—H16B0.9900
C5—H50.9500C17—H17A0.9800
C6—C71.382 (3)C17—H17B0.9800
C6—H60.9500C17—H17C0.9800
C8—C181.483 (3)C18—H18A0.9800
C9—C141.391 (3)C18—H18B0.9800
C9—C101.392 (3)C18—H18C0.9800
O2—S—O3118.98 (9)C10—C11—C12120.4 (2)
O2—S—C1108.86 (9)C10—C11—H11119.8
O3—S—C1107.68 (10)C12—C11—H11119.8
O2—S—C9108.30 (10)C13—C12—C11120.4 (2)
O3—S—C9107.87 (9)C13—C12—H12119.8
C1—S—C9104.17 (9)C11—C12—H12119.8
C8—O1—C7106.97 (15)C12—C13—C14120.3 (2)
C8—C1—C2107.64 (18)C12—C13—H13119.8
C8—C1—S125.89 (16)C14—C13—H13119.8
C2—C1—S126.07 (15)C13—C14—C9118.7 (2)
C7—C2—C3119.09 (19)C13—C14—H14120.6
C7—C2—C1104.40 (18)C9—C14—H14120.6
C3—C2—C1136.49 (19)C16—C15—C4115.6 (2)
C4—C3—C2119.1 (2)C16—C15—H15A108.4
C4—C3—H3120.4C4—C15—H15A108.4
C2—C3—H3120.4C16—C15—H15B108.4
C3—C4—C5119.6 (2)C4—C15—H15B108.4
C3—C4—C15119.7 (2)H15A—C15—H15B107.4
C5—C4—C15120.7 (2)C15—C16—C17113.4 (2)
C6—C5—C4122.4 (2)C15—C16—H16A108.9
C6—C5—H5118.8C17—C16—H16A108.9
C4—C5—H5118.8C15—C16—H16B108.9
C7—C6—C5116.4 (2)C17—C16—H16B108.9
C7—C6—H6121.8H16A—C16—H16B107.7
C5—C6—H6121.8C16—C17—H17A109.5
O1—C7—C6126.0 (2)C16—C17—H17B109.5
O1—C7—C2110.60 (18)H17A—C17—H17B109.5
C6—C7—C2123.4 (2)C16—C17—H17C109.5
C1—C8—O1110.39 (18)H17A—C17—H17C109.5
C1—C8—C18134.4 (2)H17B—C17—H17C109.5
O1—C8—C18115.24 (18)C8—C18—H18A109.5
C14—C9—C10121.3 (2)C8—C18—H18B109.5
C14—C9—S119.47 (16)H18A—C18—H18B109.5
C10—C9—S119.19 (17)C8—C18—H18C109.5
C11—C10—C9118.9 (2)H18A—C18—H18C109.5
C11—C10—H10120.6H18B—C18—H18C109.5
C9—C10—H10120.6
O2—S—C1—C8−27.3 (2)C1—C2—C7—C6−177.9 (2)
O3—S—C1—C8−157.57 (18)C2—C1—C8—O1−0.9 (2)
C9—S—C1—C888.1 (2)S—C1—C8—O1−173.94 (14)
O2—S—C1—C2160.91 (17)C2—C1—C8—C18177.5 (2)
O3—S—C1—C230.7 (2)S—C1—C8—C184.4 (4)
C9—S—C1—C2−83.72 (19)C7—O1—C8—C11.0 (2)
C8—C1—C2—C70.4 (2)C7—O1—C8—C18−177.68 (19)
S—C1—C2—C7173.44 (15)O2—S—C9—C1419.23 (19)
C8—C1—C2—C3−177.8 (2)O3—S—C9—C14149.23 (16)
S—C1—C2—C3−4.7 (3)C1—S—C9—C14−96.53 (17)
C7—C2—C3—C4−1.1 (3)O2—S—C9—C10−161.66 (16)
C1—C2—C3—C4176.9 (2)O3—S—C9—C10−31.66 (18)
C2—C3—C4—C50.7 (3)C1—S—C9—C1082.58 (17)
C2—C3—C4—C15−178.30 (18)C14—C9—C10—C11−0.2 (3)
C3—C4—C5—C60.1 (3)S—C9—C10—C11−179.34 (16)
C15—C4—C5—C6179.2 (2)C9—C10—C11—C120.1 (3)
C4—C5—C6—C7−0.6 (3)C10—C11—C12—C13−0.2 (3)
C8—O1—C7—C6177.3 (2)C11—C12—C13—C140.3 (3)
C8—O1—C7—C2−0.7 (2)C12—C13—C14—C9−0.4 (3)
C5—C6—C7—O1−177.6 (2)C10—C9—C14—C130.4 (3)
C5—C6—C7—C20.2 (3)S—C9—C14—C13179.49 (16)
C3—C2—C7—O1178.77 (17)C3—C4—C15—C16−94.1 (3)
C1—C2—C7—O10.2 (2)C5—C4—C15—C1686.9 (3)
C3—C2—C7—C60.6 (3)C4—C15—C16—C17−178.0 (2)
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
C13—H13···O3i0.952.603.355 (3)137
C18—H18C···Cgii0.983.293.947 (4)126
Symmetry codes: (i) x+1, y, z; (ii) x+1/2, −y+3/2, z+1/2.
Table 1
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
C13—H13···O3i0.952.603.355 (3)137
C18—H18C···Cgii0.983.293.947 (4)126
Symmetry codes: (i) x+1, y, z; (ii) x+1/2, −y+3/2, z+1/2.
references
References top

Brandenburg, K. (1998). DIAMOND. Crystal Impact GbR, Bonn, Germany.

Bruker (2001). SAINT and SMART. Bruker AXS Inc., Madison, Wisconsin, USA.

Choi, H. D., Seo, P. J., Son, B. W. & Lee, U. (2008a). Acta Cryst. E64, o1016.

Choi, H. D., Seo, P. J., Son, B. W. & Lee, U. (2008b). Acta Cryst. E64, o1257.

Farrugia, L. J. (1997). J. Appl. Cryst. 30, 565.

Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122.