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Acta Cryst. (2009). E65, o308    [ doi:10.1107/S1600536809000932 ]

1-Benzoyl-3-(5-quinolyl)thiourea

W.-H. Du, C.-M. Wei and W.-F. Wang

Abstract top

The title compound, C17H13N3OS, was obtained by the reaction of benzoyl chloride, ammonium thiocyanate and 5-aminoquinoline in the presence of polyethyleneglycol-400 (PEG-400) as a phase-transfer catalyst. The compound crystallized as discrete molecules linked by N-H...N and C-H...N hydrogen bonds involving all the potential donors, generating sheets parallel to (100). An intramolecular N-H...O bond is also present.

Comment top

Acyl thioureas have extensive biological activities such as bacteriostasis, weeding (Hackmann, 1960) and plant growth regulating (Sarkis & Faisal, 1985). In addition, acyl thioureas are excellent ligands, and have been widely applied in synthesis of supramolecular complexes (Pluta & Sadlej, 2001; Kaminsky et al., 2002). The title compound, (I) crystallizes as discrete molecules (Fig. 1). The full molecule is a big conjugated system because the bond lengths of C1—C7, C7—N1, C8—N1, C8—N2 and C9—N2 become shorter than standard values, and the bond lengths of C7—O1 and C8—S1 become longer than standard values. In (I) the torsion angle for C17—C9—N2—C8 of -78.2 (3)° indicates the quinoline ring is approximately orthogonal to the rest of the molecule. The molecules in (I) are linked by N1—H6···N3, N2—H7···O1 and C6—H5···N3 hydrogen bonds involving all the potential donors, generating sheets parallel to (100), as shown in Fig. 2. In addition, the bond lengths of S—C (1.655 (2)Å) and O—C(1.223 (2)Å) in (I) are longer than the bond lengths of S—C(1.6503Å) and O—C(1.201Å) in N-(4,6-dimethylpyrimidin-2-ylcarbamothioyl)benzamide (Xue et al., 2004)

Related literature top

For the biological activity of acyl thioureas, see: Hackmann (1960); Sarkis & Faisal (1985). For their application in the synthesis of supramolecular complexes, see: Pluta & Sadlej (2001); Kaminsky et al. (2002). For a related structure, see: Xue et al. (2004).

Experimental top

The title compound was synthesized as following. A mixture of benzoyl chloride (1400 mg, 10 mmol), ammonium thiocyanate (1140 mg, 15 mmol), 5-aminoquinoline (1300 mg, 9 mmol) and dichloromethane (50 ml) in the presence of PEG-400 (1200 mg, 3 mmol) as phase transfer catalyst at room temperature for 8h with stirring. The reaction mixture was evaporated to give a residue. Singles crystals suitable for X-ray analysis were obtained by slow evaporation of a mixture solution of dichloromethane and ethanol.

Refinement top

The atom H6 attached to N1 and the atom H7 attached to N2 was located in a difference Fourier map and refined with N—H distance restrained to 0.87 (2)Å, and with Uiso(H) = 0.85Ueq(N) and Uiso(H) = 1.91Ueq(N) All H atoms bound to carbon were refined using riding models with d(C—H) = 0.93Å and Uiso(H) = 1.2Ueq(C).

Computing details top

Data collection: CAD-4 Software (Enraf–Nonius, 1989); cell refinement: CAD-4 Software (Enraf–Nonius, 1989); data reduction: XCAD4 (Harms & Wocadlo, 1995); program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL (Sheldrick, 2008).

Figures top
[Figure 1] Fig. 1. The molecular structure of (I), with atom labels and 50% probability displacement ellipsoids for non-H atoms.
[Figure 2] Fig. 2. The packing of (I), viewed down the a axis, showing two layers of molecules connected by van der waals.
1-Benzoyl-3-(5-quinolyl)thiourea top
Crystal data top
C17H13N3OSF(000) = 640
Mr = 307.36Dx = 1.364 Mg m−3
Monoclinic, P21/nMelting point = 446.2–446.7 K
Hall symbol: -P 2ynMo Kα radiation, λ = 0.71073 Å
a = 5.0875 (1) ÅCell parameters from 3090 reflections
b = 16.1718 (4) Åθ = 2.2–22.4°
c = 18.2847 (4) ŵ = 0.22 mm−1
β = 95.892 (2)°T = 296 K
V = 1496.41 (6) Å3Rod, yellow
Z = 40.40 × 0.30 × 0.20 mm
Data collection top
Enraf–Nonius CAD-4
diffractometer		2184 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.032
graphiteθmax = 27.4°, θmin = 1.7°
ω/2θ scansh = −6→6
Absorption correction: ψ scan
(North et al., 1968)		k = −20→18
Tmin = 0.939, Tmax = 0.969l = −23→23
13322 measured reflections3 standard reflections every 97 reflections
3411 independent reflections intensity decay: 2.1%
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.048Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.129H atoms treated by a mixture of independent and constrained refinement
S = 1.04 w = 1/[σ2(Fo2) + (0.0482P)2 + 0.4696P]
where P = (Fo2 + 2Fc2)/3
3411 reflections(Δ/σ)max < 0.001
207 parametersΔρmax = 0.30 e Å−3
2 restraintsΔρmin = −0.22 e Å−3
Crystal data top
C17H13N3OSV = 1496.41 (6) Å3
Mr = 307.36Z = 4
Monoclinic, P21/nMo Kα radiation
a = 5.0875 (1) ŵ = 0.22 mm−1
b = 16.1718 (4) ÅT = 296 K
c = 18.2847 (4) Å0.40 × 0.30 × 0.20 mm
β = 95.892 (2)°
Data collection top
Enraf–Nonius CAD-4
diffractometer		2184 reflections with I > 2σ(I)
Absorption correction: ψ scan
(North et al., 1968)		Rint = 0.032
Tmin = 0.939, Tmax = 0.969θmax = 27.4°
13322 measured reflections3 standard reflections every 97 reflections
3411 independent reflections intensity decay: 2.1%
Refinement top
R[F2 > 2σ(F2)] = 0.048H atoms treated by a mixture of independent and constrained refinement
wR(F2) = 0.129Δρmax = 0.30 e Å−3
S = 1.04Δρmin = −0.22 e Å−3
3411 reflectionsAbsolute structure: ?
207 parametersFlack parameter: ?
2 restraintsRogers parameter: ?
Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2sigma(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
S1−0.00333 (14)0.14855 (4)0.20925 (4)0.0704 (2)
O10.5088 (4)0.09876 (10)0.02568 (9)0.0724 (5)
N10.2883 (4)0.17950 (11)0.10117 (10)0.0503 (4)
N20.2175 (4)0.04129 (12)0.12428 (10)0.0602 (5)
C170.2711 (4)−0.05169 (12)0.23117 (11)0.0442 (5)
C130.1919 (4)−0.12237 (12)0.26802 (11)0.0482 (5)
C70.4431 (5)0.16753 (13)0.04478 (11)0.0524 (5)
N30.3173 (4)−0.14846 (11)0.33306 (10)0.0579 (5)
C10.5204 (4)0.24240 (13)0.00465 (10)0.0470 (5)
C160.4940 (4)−0.00801 (14)0.26304 (13)0.0558 (6)
H130.55380.03890.24040.067*
C80.1748 (4)0.11985 (13)0.14277 (11)0.0511 (5)
C12−0.0297 (5)−0.16872 (13)0.23615 (14)0.0582 (6)
H10−0.0850−0.21560.25970.070*
C90.1265 (4)−0.02866 (13)0.16352 (12)0.0520 (5)
C11−0.1587 (5)−0.14385 (14)0.17142 (14)0.0607 (6)
H9−0.3023−0.17450.15080.073*
C20.7141 (5)0.23490 (16)−0.04248 (13)0.0650 (6)
H10.80190.1848−0.04580.078*
C150.6203 (5)−0.03616 (15)0.32799 (13)0.0621 (6)
H120.7686−0.00900.35020.075*
C140.5228 (5)−0.10613 (16)0.36003 (13)0.0637 (6)
H110.6111−0.12420.40420.076*
C60.3941 (5)0.31702 (15)0.00781 (13)0.0658 (7)
H50.26100.32320.03860.079*
C50.4626 (6)0.38332 (17)−0.03438 (14)0.0784 (8)
H40.37870.4340−0.03080.094*
C40.6519 (6)0.37434 (18)−0.08094 (14)0.0747 (7)
H30.69470.4184−0.11020.090*
C10−0.0822 (5)−0.07367 (14)0.13504 (13)0.0599 (6)
H8−0.1754−0.05780.09090.072*
C30.7785 (5)0.30086 (19)−0.08470 (15)0.0764 (8)
H20.91000.2950−0.11610.092*
H60.268 (4)0.2277 (10)0.1143 (10)0.043 (6)*
H70.324 (5)0.0371 (19)0.0876 (14)0.115 (11)*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
S10.0932 (5)0.0458 (4)0.0790 (4)0.0004 (3)0.0421 (4)0.0001 (3)
O10.1085 (14)0.0473 (10)0.0671 (10)0.0049 (9)0.0359 (10)−0.0030 (8)
N10.0701 (12)0.0363 (10)0.0461 (10)0.0012 (9)0.0131 (9)0.0013 (8)
N20.0852 (15)0.0426 (11)0.0558 (12)0.0015 (10)0.0220 (11)0.0056 (9)
C170.0501 (11)0.0343 (10)0.0503 (11)0.0001 (9)0.0159 (9)−0.0048 (9)
C130.0589 (13)0.0362 (11)0.0522 (12)0.0016 (9)0.0189 (10)−0.0032 (9)
C70.0653 (14)0.0480 (13)0.0443 (11)0.0010 (10)0.0080 (10)−0.0033 (9)
N30.0709 (13)0.0490 (11)0.0550 (11)0.0006 (10)0.0123 (10)0.0033 (9)
C10.0554 (12)0.0489 (12)0.0368 (10)−0.0039 (10)0.0048 (9)0.0001 (9)
C160.0594 (14)0.0449 (13)0.0664 (14)−0.0077 (10)0.0227 (12)−0.0067 (11)
C80.0664 (14)0.0387 (12)0.0493 (11)0.0025 (10)0.0108 (10)0.0039 (9)
C120.0687 (15)0.0393 (12)0.0692 (15)−0.0076 (10)0.0199 (12)−0.0077 (10)
C90.0642 (14)0.0401 (12)0.0536 (12)0.0027 (10)0.0154 (11)−0.0035 (10)
C110.0597 (14)0.0515 (14)0.0711 (15)−0.0089 (11)0.0068 (12)−0.0150 (12)
C20.0682 (15)0.0633 (16)0.0668 (15)0.0042 (12)0.0220 (13)0.0018 (12)
C150.0542 (14)0.0669 (16)0.0655 (15)−0.0073 (12)0.0077 (12)−0.0149 (12)
C140.0670 (16)0.0664 (16)0.0581 (14)0.0028 (13)0.0084 (12)0.0030 (12)
C60.0821 (17)0.0613 (15)0.0584 (14)0.0085 (13)0.0276 (13)0.0110 (11)
C50.104 (2)0.0613 (16)0.0740 (16)0.0143 (15)0.0295 (16)0.0208 (13)
C40.0806 (18)0.0751 (19)0.0706 (16)−0.0080 (15)0.0187 (14)0.0243 (14)
C100.0687 (15)0.0509 (14)0.0597 (14)0.0019 (12)0.0054 (12)−0.0091 (11)
C30.0728 (17)0.086 (2)0.0761 (17)−0.0040 (15)0.0362 (14)0.0121 (15)
Geometric parameters (Å, °) top
S1—C81.655 (2)C12—C111.354 (3)
O1—C71.223 (2)C12—H100.9300
N1—C71.374 (3)C9—C101.347 (3)
N1—C81.390 (3)C11—C101.391 (3)
N1—H60.826 (15)C11—H90.9300
N2—C81.338 (3)C2—C31.376 (3)
N2—C91.441 (3)C2—H10.9300
N2—H70.909 (17)C15—C141.389 (3)
C17—C131.407 (3)C15—H120.9300
C17—C161.410 (3)C14—H110.9300
C17—C91.422 (3)C6—C51.386 (3)
C13—N31.358 (3)C6—H50.9300
C13—C121.427 (3)C5—C41.357 (4)
C7—C11.490 (3)C5—H40.9300
N3—C141.304 (3)C4—C31.357 (4)
C1—C61.371 (3)C4—H30.9300
C1—C21.379 (3)C10—H80.9300
C16—C151.369 (3)C3—H20.9300
C16—H130.9300
C7—N1—C8127.96 (19)C10—C9—N2120.8 (2)
C7—N1—H6116.7 (14)C17—C9—N2118.35 (19)
C8—N1—H6115.2 (14)C12—C11—C10121.7 (2)
C8—N2—C9123.42 (19)C12—C11—H9119.1
C8—N2—H7112 (2)C10—C11—H9119.1
C9—N2—H7124 (2)C3—C2—C1120.6 (2)
C13—C17—C16117.8 (2)C3—C2—H1119.7
C13—C17—C9118.79 (19)C1—C2—H1119.7
C16—C17—C9123.39 (19)C16—C15—C14118.7 (2)
N3—C13—C17122.7 (2)C16—C15—H12120.6
N3—C13—C12118.3 (2)C14—C15—H12120.6
C17—C13—C12118.9 (2)N3—C14—C15125.1 (2)
O1—C7—N1122.5 (2)N3—C14—H11117.4
O1—C7—C1120.3 (2)C15—C14—H11117.4
N1—C7—C1117.14 (19)C1—C6—C5120.8 (2)
C14—N3—C13117.0 (2)C1—C6—H5119.6
C6—C1—C2118.1 (2)C5—C6—H5119.6
C6—C1—C7123.1 (2)C4—C5—C6120.1 (3)
C2—C1—C7118.6 (2)C4—C5—H4119.9
C15—C16—C17118.6 (2)C6—C5—H4119.9
C15—C16—H13120.7C3—C4—C5119.8 (2)
C17—C16—H13120.7C3—C4—H3120.1
N2—C8—N1115.68 (19)C5—C4—H3120.1
N2—C8—S1124.54 (17)C9—C10—C11120.3 (2)
N1—C8—S1119.78 (16)C9—C10—H8119.9
C11—C12—C13119.5 (2)C11—C10—H8119.9
C11—C12—H10120.2C4—C3—C2120.6 (2)
C13—C12—H10120.2C4—C3—H2119.7
C10—C9—C17120.8 (2)C2—C3—H2119.7
C16—C17—C13—N31.5 (3)C16—C17—C9—C10178.8 (2)
C9—C17—C13—N3−179.51 (18)C13—C17—C9—N2−176.79 (18)
C16—C17—C13—C12−178.68 (18)C16—C17—C9—N22.1 (3)
C9—C17—C13—C120.3 (3)C8—N2—C9—C10105.1 (3)
C8—N1—C7—O1−2.7 (4)C8—N2—C9—C17−78.2 (3)
C8—N1—C7—C1174.7 (2)C13—C12—C11—C10−0.4 (3)
C17—C13—N3—C14−1.8 (3)C6—C1—C2—C30.3 (3)
C12—C13—N3—C14178.4 (2)C7—C1—C2—C3175.3 (2)
O1—C7—C1—C6160.1 (2)C17—C16—C15—C14−0.4 (3)
N1—C7—C1—C6−17.3 (3)C13—N3—C14—C151.0 (4)
O1—C7—C1—C2−14.6 (3)C16—C15—C14—N30.1 (4)
N1—C7—C1—C2168.0 (2)C2—C1—C6—C5−1.0 (4)
C13—C17—C16—C15−0.4 (3)C7—C1—C6—C5−175.7 (2)
C9—C17—C16—C15−179.3 (2)C1—C6—C5—C41.7 (4)
C9—N2—C8—N1176.8 (2)C6—C5—C4—C3−1.6 (4)
C9—N2—C8—S1−4.2 (3)C17—C9—C10—C11−0.3 (3)
C7—N1—C8—N2−1.6 (3)N2—C9—C10—C11176.3 (2)
C7—N1—C8—S1179.31 (18)C12—C11—C10—C90.6 (4)
N3—C13—C12—C11179.8 (2)C5—C4—C3—C20.9 (4)
C17—C13—C12—C110.0 (3)C1—C2—C3—C4−0.3 (4)
C13—C17—C9—C10−0.1 (3)
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
N1—H6···N3i0.83 (2)2.28 (2)3.100 (3)171 (2)
N2—H7···O10.91 (3)1.84 (3)2.619 (3)143 (3)
C6—H5···N3i0.932.463.252 (3)143
Symmetry codes: (i) −x+1/2, y+1/2, −z+1/2.
Table 1
Hydrogen-bond geometry (Å, °) top
D—H···AD—HH···AD···AD—H···A
N1—H6···N3i0.83 (2)2.28 (2)3.100 (3)171 (2)
N2—H7···O10.91 (3)1.84 (3)2.619 (3)143 (3)
C6—H5···N3i0.932.463.252 (3)143
Symmetry codes: (i) −x+1/2, y+1/2, −z+1/2.
Acknowledgements top

We are grateful to the Science Foundation of Jiangsu Education Bureau (05KJD 150039), the Professor Foundation of Huaiyin Teachers Collage (05 HSJS018) and the Science Foundation of Jangsu Key Laboratory for the Chemistry of Low-Dimensional Materials (JSKC 06028) for financial support.

references
References top

Enraf–Nonius (1989). CAD-4 Software. Enraf–Nonius, Delft, The Netherlands.

Hackmann, J. T. (1960). US Patent No. 2 923 656.

Harms, K. & Wocadlo, S. (1995). XCAD4. University of Marburg, Germany.

Kaminsky, W., Goldberg, K. I. & West, D. X. (2002). J. Mol. Struct. 605, 9–15.

North, A. C. T., Phillips, D. C. & Mathews, F. S. (1968). Acta Cryst. A24, 351–359.

Pluta, T. & Sadlej, A. J. (2001). J. Chem. Phys. 114, 136–146.

Sarkis, G. Y. & Faisal, E. D. (1985). J. Heterocycl. Chem. 22, 137–140.

Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122.

Xue, S. J., Duan, L. P., Ke, S. Y. & Zhu, J. M. (2004). Chin. J. Struct. Chem. 23, 441–444.