Figure 1
Lysine-biosynthetic pathways. The abbreviations for the enzymes are as follows: DapB, dihydrodipicolinate reductase; DapD, tetrahydrodipicolinate acylase; DapC, acyl-amino-ketopimelate aminotransferase; DapE, acyl-ketopimelate deacylase; DapF, diaminopimelate epimerase; LysA, diaminopimelate decarboxylase; DapDh, meso-diaminopimelate dehydrogenase; DapL, L,L-diaminopimelate aminotransferase. The abbreviations for the compounds are as follows: (S)-ASA, (S)-aspartate-β-semialdehyde; HTPA, (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid; THDPA, tetrahydrodipicolinate; DAP, diaminopimelate. |