Figure 1
Chemical structures of adenosine-5'-triphosphate (ATP), Fasudil and H-89 in similar orientations with respect to the ATP pocket (hinge region at the left). The isoquinoline portion of H-89 is highlighted in blue, the sulfonamide portion in green and the bromobenzene moiety in red. The numbering of the H-89 molecule refers to C3 and N4, consistent with the designation of the atoms in the structure 3vqh . `PKA' refers to cAMP-dependent protein kinase catalytic subunit [alpha] isoform 1 and `ROCK2' to Rho kinase [alpha]. Affinity values were taken from the literature: *, Rajagopalan et al. (2010BB19); †, Gassel et al. (2003BB12); ++, Yano et al. (2008BB28); §, Engh et al. (1996BB11).  [article HTML]