 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 3]](hv5218fig3mag.jpg)
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Figure 3
(a) Overall structure of PDB entry 3vqh : a ternary complex of the catalytic subunit α of protein kinase A (PKA; white), the peptidic pseudosubstrate `protein kinase inhibitor' (PKI; grey) and the ATP-competitive inhibitor H-89 (yellow). (b) B/temperature factors of the H-89 conformers in the structure 3vqh plotted as spheres on the respective atoms. The values are indicated for selected atoms. (c) Binding environment of the H-89 conformers in the ATP pocket of PKA in structure 3vqh . Residues Val123, Glu127 and Asn171 form hydrogen bonds to the ligands; the bromine moieties pack against hydrophobic atoms from the side chains of Phe54 and Lys174 and some main-chain atoms of the glycine-rich loop. The inner surface of the ATP pocket is represented in red (maximum distance of 2 Å from the inhibitor molecule). |
![[Figure 3]](hv5218fig3.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
