Figure 2
(a) Kdo-(2[rightwards arrow]4)-5,6-dehydro-Kdo binds in an electropositive pocket of the S25-2 combining site. (b) Interactions (green dashes) of S25-2 with Kdo-(2[rightwards arrow]4)-5,6-dehydro-Kdo. The terminal Kdo (bottom) makes a series of interactions that are conserved in other S25-2 structures (Brooks et al., 2008BB5; Nguyen et al., 2003BB15), while the 7-OH group of 5,6-dehydro-Kdo (top) forms a single hydrogen bond to residue Asn53 in the heavy chain. Amino-acid residues in the structure are numbered according to the Kabat numbering scheme for antibodies (Kabat et al., 1983BB13); (H) refers to residues on the heavy chain and (L) refers to residues on the light chain.  [article HTML]

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