Schematic representation of the concept of the rotation electron diffraction (RED) method. RED data (individual ED frames) are collected by combining beam tilt and goniometer tilt. After three-dimensional reconstruction, the intensities and positions of the reflections in reciprocal space are obtained and can be visualized. After further data processing the unit cell is determined and the reflections are indexed. A resultant hkl list is then used to determine the atomic structure of the crystals. The example used here is the zeolite silicalite-1.