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Figure 7
Unsteady-state nucleation of HEWL crystals (step 3) is contingent on the earlier steps of protein oligomerization (1) and cluster nucleation (2). Metastable clusters (red clouds) act as nucleants of HEWL crystals (green polygons) as long as the monomer concentration is above the critical limit for heterogeneous nucleation. In these cases, cluster growth (step 4) will compete with crystal growth (step 5) for the population of monomers (single dots) and oligomers (grouped dots). However, if the concentration of monomers is too greatly depleted by steps 1 and 2, no HEWL crystals will be produced.

Journal logoJOURNAL OF
APPLIED
CRYSTALLOGRAPHY
ISSN: 1600-5767
Volume 50| Part 4| August 2017| Pages 1056-1065
https://doi.org/10.1107/S1600576717007312
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