(2R*,4S*)-2-(Pyridin-3-yl)-2,3,4,5-tetra­hydro-1H-1-benzazepin-4-ol: a three-dimensional framework built from O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds

Gómez, S.L.; Palma, A.; Cobo, J.; Glidewell, C.

doi:10.1107/S010827011101016X

organic compounds

STRUCTURAL
CHEMISTRY

ISSN: 2053-2296

Volume 67| Part 5| May 2011| Pages o157-o160

doi:10.1107/S010827011101016X

(2R,4S)-2-(Pyridin-3-yl)-2,3,4,5-tetrahydro-1H-1-benzazepin-4-ol: a three-dimensional framework built from O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds

Sandra L. Gómez,^a Alirio Palma,^a Justo Cobo ^b and Christopher Glidewell ^c ^*

^aLaboratorio de Síntesis Orgánica, Escuela de Química, Universidad Industrial de Santander, AA 678 Bucaramanga, Colombia, ^bDepartamento de Química Inorgánica y Orgánica, Universidad de Jaén, 23071 Jaén, Spain, and ^cSchool of Chemistry, University of St Andrews, Fife KY16 9ST, Scotland
^*Correspondence e-mail: cg@st-andrews.ac.uk

(Received 14 March 2011; accepted 17 March 2011; online 12 April 2011)

The title compound, C₁₅H₁₆N₂O, crystallizes in the space group P2₁2₁2₁ with Z′ = 1. The seven-membered ring adopts a chair-type conformation with the hydroxy and pyridyl substituents in equatorial sites. Molecules are linked into a three-dimensional framework structure by a combination of O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds, but N—H⋯O and N—H⋯π(arene) interactions are absent from the structure. Comparisons are made with some related compounds.

Comment

The chemistry of tetrahydro-1-benzazepine systems has been extensively investigated, and many examples of this class have been the targets in synthetic investigations because of their known biological properties, such as nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors (Tsunoda et al., 2005 ), inhibitors of cyclin-dependent kinases (Kunick et al., 2006 ), agents against HIV-1 infection (Seto et al., 2005 ) and antipsychotic agents (Zhao et al., 2003 ). The growing interest in tetrahydro-1-benzazepines has recently been boosted by their high potential value as agents against promastigotes and amastigotes of Leishmania mexicana (Knockaert et al., 2002 ), and as inhibitors of Trypanosoma cruzi dihydrofolate reductase (Zuccotto et al., 2001 ). As an extension of our current work towards the synthesis of bioactive compounds containing the tetrahydro-1-benzazepine ring system, we recently reported the synthesis and antiparasitic activity of a new series of cis-2-aryl-4-hydroxytetrahydronaphtho[1,2-b]azepines against Trypanosoma cruzi and Leishmania chagasi parasites (Palma et al., 2009 ). Here we report the structure of the title hydroxybenzazepine compound, (I) (Fig. 1), and we compare compound (I) with its close analogues 2-vinyl-2,3,4,5-tetrahydro-1-benzazepin-4-ol, (II), and 2-phenyl-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, (III), whose structures have been reported recently (Acosta et al., 2009 ; Gómez et al., 2010 ). The constitution of compound (I) differs from that of (II) in that the pendent substituent is a 3-pyridyl group in (I) as opposed to a vinyl group in (II); the constitution of (I) differs from that of (III) in that the pendent substituent is a 3-pyridyl group in (I) as opposed to a phenyl group in (III) and the amino-alcohol functionality in (I) is the reduction product of a 1,4-epoxy bridge as found in compound (III). The reductive cleavage of the N—O bond in such an epoxy bridge is readily accomplished by the use of zinc powder in 80% acetic acid, as employed in the preparation of compound (I).

Compound (I) crystallizes in the space group P2₁2₁2₁ with only one enantiomorph present in any given crystal. It was not possible to establish the absolute configuration of the molecules in the crystal selected for data collection, and the asymmetric unit was selected to be a molecule having the R configuration at atom C2; on this basis the configuration at atom C4 is S. However, the method of synthesis employed for compound (I), i.e. reduction of a racemic precursor under conditions which do not induce enantioselectivity, suggests that compound (I) should be formed as a racemic mixture, so that conglomerate crystallization has subsequently occurred. The crystallization behaviour of (I) may be contrasted with that of compounds (II) and (III), which crystallize as true racemates in the space groups P2₁/n and Cc, respectively (Acosta et al., 2009; Gómez et al., 2010).

The seven-membered ring in compound (I) adopts a chair-type conformation with both the pyridyl and the hydroxy substituents in equatorial sites. The bond distances and the interbond angles present no unusual values.

The molecules of compound (I) are linked into a three-dimensional framework structure by a combination of O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds (Table 1). The two independent C—H⋯O hydrogen bonds necessarily have a common acceptor atom, while the two C—H⋯π(arene) hydrogen bonds utilize as acceptors the two faces of the fused aryl ring. These two interactions subtend angles at the ring centroid, denoted Cg, whose values are close to 180°; thus the angles H25ⁱ⋯Cg⋯H9ⁱⁱ and C25ⁱ⋯Cg⋯C9ⁱⁱ [symmetry codes: (i) x, y + 1, z; (ii) x + $[{1\over 2}]$ , −y + $[{3\over 2}]$ , −z + 1] are 151 and 157.6 (2)°, respectively. It is striking that, although four C—H bonds are involved in hydrogen-bond formation, including three of the four C—H bonds of the pyridyl ring (Table 1), the N—H bond does not participate at all in the intermolecular hydrogen bonding. There are no potential acceptors within hydrogen-bonding range of the N1 atom and, in fact, all of the non-H atoms within 3.6 Å of the N1 atom are components of the same molecule.

Although the hydrogen-bonded framework, based on five independent hydrogen bonds, is somewhat complex overall, its formation can readily be analysed using the substructure approach (Ferguson et al., 1998a ,b ; Gregson et al., 2000 ), in terms of three substructures, two of them two-dimensional while the third substructure is one-dimensional.

The first substructure is built from the O—H⋯N and C—H⋯O hydrogen bonds. Acting individually, these three hydrogen bonds, having atoms O41, C22 and C24, respectively, as the donors, form chains of types C(8), C(7) and C(9) (Bernstein et al., 1995 ), respectively, running parallel to the [010], [100] and [110] directions. Acting together, these three hydrogen bonds form a sheet parallel to (001) and lying in the domain 0.5 < z < 1.0 (Fig. 2); two such sheets pass through each unit cell.

In the second substructure, the two C—H⋯π(arene) hydrogen bonds combine to form another type of sheet. Acting individually, the hydrogen bonds having atoms C9 and C25 as the donors form chains running parallel to the [100] and [010] directions, respectively. In combinations these two interactions generate a sheet lying parallel to (001) but now in the domain 0.3 < z < 0.7 (Fig. 3); again, two sheets of this type pass through each unit cell.

The linking of the sheets is most simply understood in terms of the third substructure. Of the five independent hydrogen bonds (Table 1), three link molecules which are related to one another by translation; by contrast, the O—H⋯N hydrogen bond and the C—H⋯π(arene) hydrogen bond utilizing atom C9 as the donor, respectively, link molecules related by the 2₁ screw axes along ( $[{1\over 2}]$ , y, $[{3\over 4}]$ ) and (x, $[{3\over 4}]$ , $[{1\over 2}]$ ). The combination of these two hydrogen bonds, acting alternately, generates a chain running parallel to the [001] direction (Fig. 4). This chain along [001] links together all of the sheets, of both types, parallel to (001), so that the combination of the three substructures generates a three-dimensional framework structure.

It is of interest briefly to compare the molecular aggregation in compound (I) with that in compounds (II) and (III). In the crystal structure of compound (II) (Acosta et al., 2009), a combination of N—H⋯O and O—H⋯N hydrogen bonds links the molecules into a chain of edge-fused R₃³(10) rings, while a single C—H⋯π(arene) hydrogen bond links chains of this type into a sheet. Thus, by contrast with compound (I), the N—H bond in compound (II) participates in the intermolecular hydrogen bonding, presumably because the steric shielding of the N—H unit afforded by the vinyl substituent in compound (II) is less than that provided by the pyridyl substituent in compound (I). There are neither N—H nor O—H bonds in compound (III), so that the intermolecular aggregation in (III) is necessarily different from that in compounds (I) and (II). Compound (III) crystallizes with Z′ = 2 in the space group Cc (Gómez et al., 2010), and molecules related by translation are linked by C—H⋯π(arene) hydrogen bonds to form two independent chains running antiparallel to one another and each containing only one type of molecule.

Figure 1
The molecular structure of the (2R,4S) enantiomer of compound (I)

, showing the atom-labelling scheme. Displacement ellipsoids are drawn at the 30% probability level.

Figure 2
A stereoview of part of the crystal structure of compound (I)

, showing the formation of a sheet lying parallel to (001) and built from O—H⋯N and C—H⋯O hydrogen bonds. For the sake of clarity, H atoms not involved in the motifs shown have been omitted.

Figure 3
A stereoview of part of the crystal structure of compound (I)

, showing the formation of a sheet lying parallel to (001) and built from C—H⋯π(arene) hydrogen bonds. For the sake of clarity, H atoms not involved in the motifs shown have been omitted.

Figure 4
A stereoview of part of the crystal structure of compound (I)

, showing the formation of a chain running parallel to [001] and built from alternating O—H⋯N and C—H⋯π(arene) hydrogen bonds. For the sake of clarity, H atoms not involved in the motifs shown have been omitted.

Experimental

Zinc powder (0.8 mmol) was added to a solution of racemic (2RS,4SR)-2-exo-(pyridin-3-yl)-1,4-epoxy-2,3,4,5-tetrahydro-1-benzazepine (0.1 mmol) in 80% acetic acid (15 ml). The resulting mixture was stirred at 318 K for 3 h. The mixture was filtered, and the filtrate was neutralized with aqueous ammonia solution to pH = 8 and then extracted with ethyl acetate (3 × 50 ml). The combined extracts were dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure to give the crude product which was purified by column chromatography on silica gel using heptane–ethyl acetate (10:1 to 1:1 v/v) as eluent. Recrystallization from heptane–ethyl acetate (1:4 v/v) gave colourless crystals suitable for single-crystal X-ray diffraction (yield 86%, m.p. 403–404 K). MS (70 eV) m/z (%): 240 (M⁺, 74), 221 (13), 195 (61), 130 (11), 118 (100), 106 (74), 91 (21), 77 (16).

Crystal data

C₁₅H₁₆N₂O
M_r = 240.30
Orthorhombic, P 2₁ 2₁ 2₁
a = 6.0318 (9) Å
b = 8.3396 (10) Å
c = 25.361 (4) Å
V = 1275.7 (3) Å³
Z = 4
Mo Kα radiation
μ = 0.08 mm⁻¹
T = 120 K
0.40 × 0.22 × 0.20 mm

Data collection

Bruker–Nonius KappaCCD diffractometer
Absorption correction: multi-scan (SADABS; Sheldrick, 2003 ) T_min = 0.969, T_max = 0.984
10571 measured reflections
1714 independent reflections
1453 reflections with I > 2σ(I)
R_int = 0.034

Refinement

R[F² > 2σ(F²)] = 0.035
wR(F²) = 0.086
S = 1.11
1714 reflections
163 parameters
H-atom parameters constrained
Δρ_max = 0.16 e Å⁻³
Δρ_min = −0.22 e Å⁻³

Table 1
Hydrogen-bond geometry (Å, °)

Cg is the centroid of the C5A/C6–C9/C9A ring.

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O41—H41⋯N23ⁱ	0.86	1.94	2.786 (2)	168
C22—H22⋯O41ⁱⁱ	0.95	2.47	3.288 (2)	145
C24—H24⋯O41ⁱⁱⁱ	0.95	2.49	3.436 (2)	175
C9—H9⋯Cg^iv	0.95	2.83	3.633 (2)	143
C25—H25⋯Cg^v	0.95	2.77	3.633 (2)	151
Symmetry codes: (i) $[-x+1, y+{\script{1\over 2}}, -z+{\script{3\over 2}}]$ ; (ii) x-1, y, z; (iii) x-1, y-1, z; (iv) $[x-{\script{1\over 2}}, -y+{\script{3\over 2}}, -z+1]$ ; (v) x, y-1, z.

All H atoms were located in difference maps and subsequently treated as riding atoms in geometrically idealized positions, with C—H distances = 0.95 (aromatic and heteroaromatic), 0.99 (CH₂) or 1.00 Å (aliphatic CH), N—H = 0.88 Å and O—H = 0.86 Å, and with U_iso(H) = kU_eq(carrier), where k = 1.5 for hydroxy atom H41 and 1.2 otherwise. In the absence of significant resonant scattering, the values of the Flack x parameter (Flack, 1983 ) and the Hooft y parameter (Hooft et al., 2008 ), viz. 0.2 (15) and 0.6 (7), respectively, were indeterminate (Flack & Bernardinelli, 2000 ). Accordingly, the Friedel-equivalent reflections were merged prior to the final refinements, and the asymmetric unit was arbitrarily selected as having the R configuration at atom C2, and hence the S configuration at atom C4.

Data collection: COLLECT (Hooft, 1999 ); cell refinement: DIRAX/LSQ (Duisenberg et al., 2000 ); data reduction: EVALCCD (Duisenberg et al., 2003 ); program(s) used to solve structure: SIR2004 (Burla et al., 2005 ); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ); molecular graphics: PLATON (Spek, 2009 ); software used to prepare material for publication: SHELXL97 and PLATON.

Supporting information

Crystal structure: contains datablocks global, I. DOI: 10.1107/S010827011101016X/sk3404sup1.cif

Structure factors: contains datablock I. DOI: 10.1107/S010827011101016X/sk3404Isup2.hkl

Comment top

The chemistry of tetrahydro-1-benzazepine systems has been extensively investigated, and many examples of this class have been the targets in synthetic investigations because of their known biological properties, such as non-peptide arginine vasopressin antagonists for both V1A and V2 receptors (Tsunoda et al., 2005), inhibitors of cyclin-dependent kinases (Kunick et al., 2006), agents against HIV-1 infection (Seto et al., 2005) and anti-psychotic agents (Zhao et al., 2003). The growing interest in tetrahydro-1-benzazepines has recently been boosted by their high potential value as agents against promastigotes and amastigotes of Leishmania mexicana (Knockaert et al., 2002), and as inhibitors of Trypanosoma cruzi dihydrofolate reductase (Zuccotto et al., 2001). As an extension of our current work towards the synthesis of bioactive compounds containing the tetrahydro-1-benzazepine ring system, we recently reported the synthesis and anti-parasitic activity of a new series of cis-2-aryl-4-hydroxytetrahydronaphtho[1,2-b]azepines against Trypanosoma cruzi and Leishmania chagasi parasites (Palma et al., 2009). Here we report the structure of the title hydroxybenzazepine compound, (I) (Fig. 1), and we compare compound (I) with its close analogues 2-vinyl-2,3,4,5-tetrahydro-1-benzazepin-4-ol, (II), and 2-phenyl-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, (III), whose structures have recently been reported (Acosta et al., 2009; Gómez et al., 2010). The constitution of compound (I) differs from that of (II) in that the pendent substituent is a 3-pyridyl group in (I) as opposed to a vinyl group in (II); the constitution of (I) differs from that of (III) in that the pendent substituent is a 3-pyridyl group in (I) as opposed to a phenyl group in (III) and the amino-alcohol functionality in (I) is the reduction product of a 1,4-epoxy bridge as found in compound (III). The reductive cleavage of the N—O bond in such an epoxy bridge is readily accomplished by the use of zinc powder in 80% acetic acid, as employed in the preparation of compound (I).

Compound (I) crystallizes in the space group P2₁2₁2₁ with only one enantiomorph present in any given crystal. It was not possible to establish the absolute configuration of the molecules in the crystal selected for data collection, and the asymmetric unit was selected to be a molecule having the R configuration at atom C2: on this basis the configuration at atom C4 is S in the selected asymmetric unit. However, the method of synthesis employed for compound (I), i.e. reduction of a racemic precursor under conditions which do not induce enantioselectivity, suggests that compound (I) should be formed as a racemic mixture, so that conglomerate crystallization has subsequently occurred. The crystallization behaviour of (I) may be contrasted with that of compounds (II) and (III), which crystallize as true racemates in the space groups P2₁/n and Cc, respectively (Acosta et al., 2009; Gómez et al., 2010).

The molecules of compound (I) are linked into a three-dimensional framework structure by a combination of O—H···N, C—H···O and C—H···π(arene) hydrogen bonds (Table 1). The two independent C—H···O hydrogen bonds necessarily have a common acceptor atom, while the two C—H···π(arene) hydrogen bonds utilize as acceptors the two faces of the fused aryl ring. These two interactions subtend angles at the ring centroid, denoted Cg, whose values are close to 180°; thus the angles H25ⁱ···Cg···H9ⁱⁱ and C25ⁱ···Cg···C9ⁱⁱ [symmetry codes: (i) x, y + 1, z; (ii) x + 1/2, -y + 3/2, -z + 1] are 151 and 157.6 (2)°, respectively. It is striking that, although four C—H bonds are involved in hydrogen-bond formation, including three of the four C—H bonds of the pyridyl ring (Table 1), the N—H bond does not participate at all in the intermolecular hydrogen bonding. There are no potential acceptors within hydrogen-bonding range of the N1 atom and, in fact, all of the non-H atoms within 3.6 Å of the N1 atom are components of the same molecule.

Although the hydrogen-bonded framework, based on five independent hydrogen bonds, is somewhat complex overall, its formation can readily be analysed using the substructure approach (Ferguson et al., 1998a,b; Gregson et al., 2000), in terms of three substructures, two of them two-dimensional while the third substructure is one-dimensional.

The first substructure is built from the O—H···N and C—H···O hydrogen bonds. Acting individually, these three hydrogen bonds, having atoms O41, C22 and C24, respectively, as the donors, form chains of types C(8), C(7) and C(9) (Bernstein et al., 1995), respectively, running parallel to the [010], [100] and [110] directions. Acting together, these three hydrogen bonds form a sheet parallel to (001) and lying in the domain 0.5 < z < 1.0 (Fig. 2); two such sheets pass through each unit cell.

In the second substructure, the two C—H···π(arene) hydrogen bonds combine to form another type of sheet. Acting individually, the hydrogen bonds having atoms C9 and C25 as the donors form chains running parallel to the [100] and [010] directions, respectively. In combinations these two interactions generate a sheet lying parallel to (001) but now in the domain 0.3 < z < 0.7 (Fig. 3); again, two sheets of this type pass through each unit cell.

The linking of the sheets is most simply understood in terms of the third substructure. Of the five independent hydrogen bonds (Table 1), three link molecules which are related to one another by translation; by contrast, the O—H···N hydrogen bond and the C—H···π(arene) hydrogen bond utilizing atom C9 as the donor, respectively, link molecules related by the 2₁ screw axes along (1/2, y, 3/4) and (x, 3/4, 1/2). The combination of these two hydrogen bonds, acting alternately, generates a chain running parallel to the [001] direction (Fig. 4). This chain along [001] links together all of the sheets, of both types, parallel to (001), so that the combination of the three substructures generates a three-dimensional framework structure.

It is of interest briefly to compare the molecular aggregation in compound (I) with that in compounds (II) and (III). In the crystal structure of compound (II) (Acosta et al., 2009), a combination of N—H···O and O—H···N hydrogen bonds links the molecules into a chain of edge-fused R₃³(10) rings, while a single C—H···π(arene) hydrogen bond links chains of this type into a sheet. Thus, by contrast with compound (I), the N—H bond in compound (II) participates in the intermolecular hydrogen bonding, presumably because the steric shielding of the N—H unit afforded by the vinyl substituent in compound (II) is less than that provided by the pyridyl substituent in compound (I). There are neither N—H nor O—H bonds in compound (III), so that the intermolecular aggregation in (III) is necessarily different from that in compounds (I) and (II). Compound (III) crystallizes with Z' = 2 in space group Cc (Gómez et al., 2010), and molecules related by translation are linked by C—H···π(arene) hydrogen bonds to form two independent chains running anti-parallel to one another and each containing only one type of molecule.

Related literature top

For related literature, see: Acosta et al. (2009); Bernstein et al. (1995); Ferguson et al. (1998a, 1998b); Flack (1983); Flack & Bernardinelli (2000); Gómez et al. (2010); Gregson et al. (2000); Hooft et al. (2008); Knockaert et al. (2002); Kunick et al. (2006); Palma et al. (2009); Seto et al. (2005); Tsunoda et al. (2005); Zhao et al. (2003); Zuccotto et al. (2001).

Experimental top

Computing details top

Data collection: COLLECT (Hooft, 1999); cell refinement: DIRAX/LSQ (Duisenberg et al., 2000); data reduction: EVALCCD (Duisenberg et al., 2003); program(s) used to solve structure: SIR2004 (Burla et al., 2005); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: PLATON (Spek, 2009); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).

Figures top

	Fig. 1. The molecular structure of the (2R,4S) enantiomer of compound (I), showing the atom-labelling scheme. Displacement ellipsoids are drawn at the 30% probability level.
	Fig. 2. A stereoview of part of the crystal structure of compound (I), showing the formation of a sheet lying parallel to (001) and built from O—H···N and C—H···O hydrogen bonds. For the sake of clarity, H atoms not involved in the motifs shown have been omitted.
	Fig. 3. A stereoview of part of the crystal structure of compound (I), showing the formation of a sheet lying parallel to (001) and built from C—H···π(arene) hydrogen bonds. For the sake of clarity, H atoms not involved in the motifs shown have been omitted.
	Fig. 4. A stereoview of part of the crystal structure of compound (I), showing the formation of a chain running parallel to [001] and built from alternating O—H···N and C—H···π(arene) hydrogen bonds. For the sake of clarity, H atoms not involved in the motifs shown have been omitted.

(2R*,4S*)-2-(Pyridin-3-yl)-2,3,4,5-tetrahydro-1H- 1-benzazepin-4-ol top

Crystal data top

C₁₅H₁₆N₂O	F(000) = 512
M_r = 240.30	D_x = 1.251 Mg m⁻³
Orthorhombic, P2₁2₁2₁	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 1714 reflections
a = 6.0318 (9) Å	θ = 2.9–27.5°
b = 8.3396 (10) Å	µ = 0.08 mm⁻¹
c = 25.361 (4) Å	T = 120 K
V = 1275.7 (3) Å³	Block, colourless
Z = 4	0.40 × 0.22 × 0.20 mm

Data collection top

Bruker–Nonius KappaCCD diffractometer	1714 independent reflections
Radiation source: Bruker-Nonius FR591 rotating anode	1453 reflections with I > 2σ(I)
Graphite monochromator	R_int = 0.034
Detector resolution: 9.091 pixels mm^-1	θ_max = 27.5°, θ_min = 2.9°
ϕ and ω scans	h = −7→7
Absorption correction: multi-scan (SADABS; Sheldrick, 2003)	k = −10→10
T_min = 0.969, T_max = 0.984	l = −32→32
10571 measured reflections

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F² > 2σ(F²)] = 0.035	Hydrogen site location: inferred from neighbouring sites
wR(F²) = 0.086	H-atom parameters constrained
S = 1.11	w = 1/[σ²(F_o²) + (0.038P)² + 0.280P] where P = (F_o² + 2F_c²)/3
1714 reflections	(Δ/σ)_max = 0.001
163 parameters	Δρ_max = 0.16 e Å⁻³
0 restraints	Δρ_min = −0.22 e Å⁻³

Crystal data top

C₁₅H₁₆N₂O	V = 1275.7 (3) Å³
M_r = 240.30	Z = 4
Orthorhombic, P2₁2₁2₁	Mo Kα radiation
a = 6.0318 (9) Å	µ = 0.08 mm⁻¹
b = 8.3396 (10) Å	T = 120 K
c = 25.361 (4) Å	0.40 × 0.22 × 0.20 mm

Data collection top

Bruker–Nonius KappaCCD diffractometer	1714 independent reflections
Absorption correction: multi-scan (SADABS; Sheldrick, 2003)	1453 reflections with I > 2σ(I)
T_min = 0.969, T_max = 0.984	R_int = 0.034
10571 measured reflections

Refinement top

R[F² > 2σ(F²)] = 0.035	0 restraints
wR(F²) = 0.086	H-atom parameters constrained
S = 1.11	Δρ_max = 0.16 e Å⁻³
1714 reflections	Δρ_min = −0.22 e Å⁻³
163 parameters

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
N1	0.5641 (3)	0.66510 (18)	0.58267 (6)	0.0225 (4)
H1	0.4493	0.6219	0.5666	0.027*
C2	0.5329 (3)	0.6467 (2)	0.63979 (7)	0.0213 (4)
H2	0.4285	0.7313	0.6526	0.026*
C3	0.7485 (3)	0.6577 (2)	0.67083 (7)	0.0221 (4)
H3A	0.7154	0.6372	0.7085	0.027*
H3B	0.8487	0.5714	0.6586	0.027*
C4	0.8697 (3)	0.8154 (2)	0.66667 (7)	0.0208 (4)
H4	0.7648	0.9048	0.6750	0.025*
C5	0.9656 (3)	0.8408 (2)	0.61214 (7)	0.0225 (4)
H5A	1.0892	0.9186	0.6146	0.027*
H5B	1.0276	0.7380	0.5994	0.027*
C5A	0.8016 (3)	0.9007 (2)	0.57285 (7)	0.0214 (4)
C6	0.8450 (4)	1.0411 (2)	0.54530 (7)	0.0249 (4)
H6	0.9742	1.1009	0.5538	0.030*
C7	0.7071 (4)	1.0965 (3)	0.50604 (8)	0.0278 (5)
H7	0.7429	1.1914	0.4871	0.033*
C8	0.5160 (4)	1.0123 (2)	0.49452 (7)	0.0264 (5)
H8	0.4193	1.0487	0.4675	0.032*
C9	0.4664 (4)	0.8756 (2)	0.52236 (7)	0.0238 (4)
H9	0.3325	0.8200	0.5150	0.029*
C9A	0.6077 (3)	0.8171 (2)	0.56089 (7)	0.0208 (4)
O41	1.0497 (2)	0.81953 (15)	0.70290 (5)	0.0223 (3)
H41	0.9927	0.8216	0.7340	0.033*
C21	0.4325 (3)	0.4841 (2)	0.64981 (7)	0.0213 (4)
C22	0.2805 (3)	0.4645 (2)	0.69002 (7)	0.0221 (4)
H22	0.2363	0.5569	0.7092	0.026*
N23	0.1921 (3)	0.3246 (2)	0.70353 (6)	0.0248 (4)
C24	0.2547 (4)	0.1954 (2)	0.67638 (8)	0.0270 (5)
H24	0.1937	0.0942	0.6857	0.032*
C25	0.4033 (4)	0.2023 (2)	0.63554 (8)	0.0306 (5)
H25	0.4432	0.1081	0.6168	0.037*
C26	0.4938 (4)	0.3487 (2)	0.62222 (8)	0.0280 (5)
H26	0.5977	0.3561	0.5942	0.034*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
N1	0.0250 (9)	0.0204 (7)	0.0220 (8)	−0.0057 (8)	−0.0025 (7)	−0.0009 (6)
C2	0.0221 (10)	0.0196 (9)	0.0223 (9)	−0.0016 (9)	0.0003 (8)	−0.0006 (7)
C3	0.0235 (10)	0.0209 (9)	0.0220 (9)	−0.0015 (9)	−0.0005 (8)	0.0016 (8)
C4	0.0195 (9)	0.0219 (9)	0.0210 (8)	−0.0020 (9)	−0.0021 (8)	−0.0011 (8)
C5	0.0208 (9)	0.0228 (9)	0.0238 (9)	−0.0031 (9)	0.0011 (8)	0.0001 (8)
C5A	0.0234 (10)	0.0206 (8)	0.0201 (9)	−0.0011 (8)	0.0015 (8)	−0.0014 (8)
C6	0.0282 (11)	0.0219 (9)	0.0247 (9)	−0.0044 (9)	0.0015 (9)	−0.0016 (8)
C7	0.0355 (12)	0.0222 (9)	0.0256 (10)	0.0017 (10)	0.0019 (10)	0.0034 (8)
C8	0.0319 (11)	0.0253 (10)	0.0219 (9)	0.0046 (9)	−0.0043 (9)	−0.0012 (8)
C9	0.0237 (10)	0.0245 (9)	0.0231 (9)	0.0017 (9)	−0.0013 (8)	−0.0045 (8)
C9A	0.0239 (10)	0.0194 (9)	0.0191 (8)	−0.0004 (8)	0.0026 (8)	−0.0026 (7)
O41	0.0216 (6)	0.0251 (7)	0.0201 (6)	−0.0021 (7)	−0.0021 (6)	−0.0013 (6)
C21	0.0208 (10)	0.0198 (9)	0.0231 (9)	−0.0016 (9)	−0.0034 (9)	−0.0007 (7)
C22	0.0225 (10)	0.0196 (9)	0.0241 (9)	−0.0001 (9)	0.0002 (8)	−0.0013 (8)
N23	0.0271 (9)	0.0240 (8)	0.0234 (8)	−0.0033 (8)	0.0003 (7)	0.0003 (7)
C24	0.0336 (12)	0.0198 (9)	0.0276 (10)	−0.0065 (10)	−0.0018 (9)	0.0014 (8)
C25	0.0405 (13)	0.0204 (9)	0.0310 (10)	−0.0021 (10)	0.0070 (10)	−0.0059 (8)
C26	0.0297 (11)	0.0252 (10)	0.0291 (10)	−0.0042 (9)	0.0076 (9)	−0.0039 (8)

Geometric parameters (Å, º) top

N1—C9A	1.408 (2)	C6—H6	0.9500
N1—C2	1.469 (2)	C7—C8	1.381 (3)
N1—H1	0.8800	C7—H7	0.9500
C2—C21	1.506 (3)	C8—C9	1.374 (3)
C2—C3	1.523 (3)	C8—H8	0.9500
C2—H2	1.0000	C9—C9A	1.385 (3)
C3—C4	1.509 (3)	C9—H9	0.9500
C3—H3A	0.9900	O41—H41	0.8604
C3—H3B	0.9900	C21—C26	1.379 (3)
C4—O41	1.423 (2)	C21—C22	1.381 (3)
C4—C5	1.514 (2)	C22—N23	1.327 (3)
C4—H4	1.0000	C22—H22	0.9500
C5—C5A	1.490 (3)	N23—C24	1.333 (3)
C5—H5A	0.9900	C24—C25	1.371 (3)
C5—H5B	0.9900	C24—H24	0.9500
C5A—C6	1.388 (3)	C25—C26	1.379 (3)
C5A—C9A	1.395 (3)	C25—H25	0.9500
C6—C7	1.378 (3)	C26—H26	0.9500

C9A—N1—C2	120.34 (15)	C7—C6—H6	118.9
C9A—N1—H1	109.5	C5A—C6—H6	118.9
C2—N1—H1	108.2	C6—C7—C8	119.09 (19)
N1—C2—C21	108.19 (15)	C6—C7—H7	120.5
N1—C2—C3	113.19 (16)	C8—C7—H7	120.5
C21—C2—C3	108.07 (15)	C9—C8—C7	119.7 (2)
N1—C2—H2	109.1	C9—C8—H8	120.2
C21—C2—H2	109.1	C7—C8—H8	120.2
C3—C2—H2	109.1	C8—C9—C9A	121.4 (2)
C4—C3—C2	115.49 (15)	C8—C9—H9	119.3
C4—C3—H3A	108.4	C9A—C9—H9	119.3
C2—C3—H3A	108.4	C9—C9A—C5A	119.56 (18)
C4—C3—H3B	108.4	C9—C9A—N1	118.61 (17)
C2—C3—H3B	108.4	C5A—C9A—N1	121.43 (17)
H3A—C3—H3B	107.5	C4—O41—H41	106.7
O41—C4—C3	110.24 (15)	C26—C21—C22	117.06 (17)
O41—C4—C5	107.15 (15)	C26—C21—C2	122.96 (18)
C3—C4—C5	111.79 (16)	C22—C21—C2	119.89 (17)
O41—C4—H4	109.2	N23—C22—C21	124.16 (18)
C3—C4—H4	109.2	N23—C22—H22	117.9
C5—C4—H4	109.2	C21—C22—H22	117.9
C5A—C5—C4	113.84 (16)	C22—N23—C24	117.60 (17)
C5A—C5—H5A	108.8	N23—C24—C25	122.75 (18)
C4—C5—H5A	108.8	N23—C24—H24	118.6
C5A—C5—H5B	108.8	C25—C24—H24	118.6
C4—C5—H5B	108.8	C24—C25—C26	118.77 (19)
H5A—C5—H5B	107.7	C24—C25—H25	120.6
C6—C5A—C9A	118.05 (18)	C26—C25—H25	120.6
C6—C5A—C5	119.61 (18)	C25—C26—C21	119.66 (18)
C9A—C5A—C5	122.29 (17)	C25—C26—H26	120.2
C7—C6—C5A	122.2 (2)	C21—C26—H26	120.2

C9A—N1—C2—C21	165.60 (17)	C5—C5A—C9A—C9	−177.25 (18)
C9A—N1—C2—C3	−74.7 (2)	C6—C5A—C9A—N1	172.71 (17)
N1—C2—C3—C4	61.8 (2)	C5—C5A—C9A—N1	−4.7 (3)
C21—C2—C3—C4	−178.38 (16)	C2—N1—C9A—C9	−122.91 (19)
C2—C3—C4—O41	171.70 (15)	C2—N1—C9A—C5A	64.4 (2)
C2—C3—C4—C5	−69.2 (2)	N1—C2—C21—C26	39.1 (3)
O41—C4—C5—C5A	−158.11 (16)	C3—C2—C21—C26	−83.8 (2)
C3—C4—C5—C5A	81.0 (2)	N1—C2—C21—C22	−144.45 (18)
C4—C5—C5A—C6	124.50 (19)	C3—C2—C21—C22	92.6 (2)
C4—C5—C5A—C9A	−58.2 (2)	C26—C21—C22—N23	0.3 (3)
C9A—C5A—C6—C7	−1.9 (3)	C2—C21—C22—N23	−176.35 (19)
C5—C5A—C6—C7	175.55 (18)	C21—C22—N23—C24	−0.1 (3)
C5A—C6—C7—C8	1.7 (3)	C22—N23—C24—C25	−0.4 (3)
C6—C7—C8—C9	0.2 (3)	N23—C24—C25—C26	0.6 (3)
C7—C8—C9—C9A	−2.0 (3)	C24—C25—C26—C21	−0.4 (3)
C8—C9—C9A—C5A	1.8 (3)	C22—C21—C26—C25	−0.1 (3)
C8—C9—C9A—N1	−171.01 (17)	C2—C21—C26—C25	176.5 (2)
C6—C5A—C9A—C9	0.1 (3)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
O41—H41···N23ⁱ	0.86	1.94	2.786 (2)	168
C22—H22···O41ⁱⁱ	0.95	2.47	3.288 (2)	145
C24—H24···O41ⁱⁱⁱ	0.95	2.49	3.436 (2)	175
C9—H9···Cg^iv	0.95	2.83	3.633 (2)	143
C25—H25···Cg^v	0.95	2.77	3.633 (2)	151

Symmetry codes: (i) −x+1, y+1/2, −z+3/2; (ii) x−1, y, z; (iii) x−1, y−1, z; (iv) x−1/2, −y+3/2, −z+1; (v) x, y−1, z.

Experimental details

Crystal data
Chemical formula	C₁₅H₁₆N₂O
M_r	240.30
Crystal system, space group	Orthorhombic, P2₁2₁2₁
Temperature (K)	120
a, b, c (Å)	6.0318 (9), 8.3396 (10), 25.361 (4)
V (Å³)	1275.7 (3)
Z	4
Radiation type	Mo Kα
µ (mm⁻¹)	0.08
Crystal size (mm)	0.40 × 0.22 × 0.20

Data collection
Diffractometer	Bruker–Nonius KappaCCD diffractometer
Absorption correction	Multi-scan (SADABS; Sheldrick, 2003)
T_min, T_max	0.969, 0.984
No. of measured, independent and observed [I > 2σ(I)] reflections	10571, 1714, 1453
R_int	0.034
(sin θ/λ)_max (Å⁻¹)	0.650

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.035, 0.086, 1.11
No. of reflections	1714
No. of parameters	163
H-atom treatment	H-atom parameters constrained
Δρ_max, Δρ_min (e Å⁻³)	0.16, −0.22

Computer programs: COLLECT (Hooft, 1999), DIRAX/LSQ (Duisenberg et al., 2000), EVALCCD (Duisenberg et al., 2003), SIR2004 (Burla et al., 2005), SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
O41—H41···N23ⁱ	0.86	1.94	2.786 (2)	168
C22—H22···O41ⁱⁱ	0.95	2.47	3.288 (2)	145
C24—H24···O41ⁱⁱⁱ	0.95	2.49	3.436 (2)	175
C9—H9···Cg^iv	0.95	2.83	3.633 (2)	143
C25—H25···Cg^v	0.95	2.77	3.633 (2)	151

Symmetry codes: (i) −x+1, y+1/2, −z+3/2; (ii) x−1, y, z; (iii) x−1, y−1, z; (iv) x−1/2, −y+3/2, −z+1; (v) x, y−1, z.

Acknowledgements

The authors thank `Centro de Instrumentación Científico-Técnica of Universidad de Jaén' and the staff for data collection. SLG and AP thank COLCIENCIAS for financial support (grant No. 1102-408-20563). JC thanks the Consejería de Innovación, Ciencia y Empresa (Junta de Andalucía, Spain), the Universidad de Jaén (project reference UJA_07_16_33) and Ministerio de Ciencia e Innovación (project reference SAF2008-04685-C02-02) for financial support.

References

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STRUCTURAL
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ISSN: 2053-2296

Volume 67| Part 5| May 2011| Pages o157-o160

doi:10.1107/S010827011101016X

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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

(2R*,4S*)-2-(Pyridin-3-yl)-2,3,4,5-tetra­hydro-1H-1-benzazepin-4-ol: a three-dimensional framework built from O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds

Comment

Experimental

Crystal data

Data collection

Refinement

Supporting information

Acknowledgements

References

organic compounds

(2R,4S)-2-(Pyridin-3-yl)-2,3,4,5-tetrahydro-1H-1-benzazepin-4-ol: a three-dimensional framework built from O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds