Nogo Receptor crystal structures with a native di­sulfide pattern suggest a novel mode of self-interaction

This work describes eight crystal forms of the neuronal Nogo Receptor, a cell-surface receptor involved in neuronal plasticity. These are the first structures of this protein with a native disulfide pattern, and suggest a novel mode of self-interaction.

Synergy among phase-refinement techniques in macromolecular crystallography

The synergy between current phase-refinement techniques and out-of-mainstream refinement methods leads to a dramatic advance in the state of the art.

Structure and function of the thermostable L-asparaginase from Thermococcus kodakarensis

The crystal structure of the L-asparaginase from T. kodakarensis has been determined at 2.18 Å resolution, revealing a number of distinctive structural features. This enzyme has many applications in food processing and chemotherapy.

Crystal structures of serum albumins from domesticated ruminants and their complexes with 3,5-di­iodosalicylic acid

Six crystal structures of serum albumins, caprine (two forms), ovine (two forms) and their complexes with 3,5-diiodosalicylic acid (DIS), have been determined at resolutions in the range 1.78–2.55 Å. Comparison with homologous complexes of bovine, equine and human serum albumins shows surprising differences in their DIS-binding properties.

Structural basis of antigen recognition: crystal structure of duck egg lysozyme

Lysozyme isoforms purified from duck eggs have been characterized by crystallography, mass spectrometry and their capacity to bind landmark antibodies.

The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metal

YiuA, a Yersinia pestis substrate-binding protein, contains a putative basic triad binding motif in the canonical substrate-binding site, indicative of a metal-chelate complex binding site. Additional structural and simulation analyses support the putative function of YiuA binding bacterial siderophores.

Four highly pseudosymmetric and/or twinned structures of d(CGCGCG)₂ extend the repertoire of crystal structures of Z-DNA

Four highly pseudomerohedrally twinned crystal structures of the hexamer duplex d(CGCGCG)₂ in the left-handed Z-DNA form are described and are compared with other pseudohexagonal crystal structures of Z-DNA oligomers.

Iron Metabolism. From Molecular Mechanisms to Clinical Consequences