issue contents

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983

March 2019 issue

Highlighted illustration

Cover illustration: A 60-heme reductase complex from an anammox bacterium shows an extended electron transfer pathway [Dietl et al. (2019), Acta Cryst. D75, 333-341]. Arrangement of the hemes in the KsHAOr-KsDH heterododecamer. A view from the top of the upper half of the complex is depicted, containing 30 hemes, which are arranged as a three-armed spiral.

research papers


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Different modes of data collection are explored, and the effect of flux and multiplicity on the resulting quality of the data set is discussed. Advice is offered on how to collect data in the absence of prior knowledge of the sample.

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A broadly applicable, simple and fast data-collection strategy for native SAD is described, which has become the primary choice for experimental phasing among users of the macromolecular crystallography beamline X06DA (PXIII) at the Swiss Light Source. Its usage over the last four years is reviewed.

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Solution structures of complexes between human serum albumin and the two lipidated insulin analogues detemir and degludec are presented and models for the equilibria are suggested.

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The disulfide isomerase α-DsbA2 from Wolbachia pipientisis is unexpectedly homotrimeric and lacks the `shape-shifting' conformational flexibility that defines another trimeric disulfide isomerase, ScsC from Proteus mirabilis.

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The structure and function of a bacterial trimeric protein disulfide isomerase was investigated by characterising two variants in which key structural regions were deleted. In one case the effect on structure and function was predictable, while in the other we found unintended consequences for both structure and function.

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The crystal structure of pyroglutamate (pG) bound PCP I enzyme reveals the mechanism of its pG specificity. The residues of a conserved active-site loop interact with pG via phenylalanine stacking interactions and hydrogen bonds.

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This article describes the methodological approach used to solve the structure of human IBA57; to our knowledge, this is the only structure present in the Protein Data Bank which has been solved in-house by remote SAD phasing in space group P1 using only one crystal.

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Cysteine proteases are among the most prominent hydrolytic enzymes produced by human distal gut commensal bacteria. Here, the first inactive zymogen structure of a clostripain-like C11 protease family member is reported from the bacterium Parabacteroides distasonis.

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The heterododecameric complex of a reducing octaheme cytochrome c with its redox partner shows an extended electron transfer pathway.

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The solution of a structure of human Rab27a suffering from severe anisotropy and translational noncrystallographic symmetry was aided by identifying diffraction measurements with low information content.

obituaries


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Nobel Prize winner Tom Steitz is remembered by his former colleague Poul Nissen.

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