organic compounds
7,14-Bis(4-bromophenyl)-2,11,11-trimethyl-1,4,10,12-tetraoxadispiro[4.2.5.2]pentadecane-9,13-dione
aLianyungang Teachers' College, Lianyungang 222006, People's Republic of China, and bSchool of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, People's Republic of China
*Correspondence e-mail: mollingmn1984@yahoo.com.cn
In the molecule of the title compound, C26H26Br2O6, the cyclohexane ring is in a chair conformation, while the five-membered and 1,3-dioxane rings both adopt envelope conformations. The dihedral angle between the benzene rings is 77.21 (3)°. In the weak intermolecular C—H⋯O interactions link the molecules into centrosymmetric dimers, forming R22(14) ring motifs. One of the Br atoms, the methyl C and H atoms, and the C atom bonded to the methyl group of the five-membered ring are disordered over two positions. The Br atoms were refined with occupancies of 0.51 (4) and 0.49 (4), while the C and H atoms were refined with occupancies of 0.320 (18) and 0.680 (18).
Related literature
For general background, see: Davidson & Bernhard (1948); Meldrum (1908); Muller et al. (2005); Ramachary et al. (2003); Tietze & Beifuss (1993); Tietze et al. (2001). For related structures, see: Chande & Khanwelkar (2005); Ramachary & Barbas (2004). For bond-length data, see: Allen et al. (1987). For ring-puckering parameters, see: Cremer & Pople (1975). For graph-set notation, see: Bernstein et al. (1995).
Experimental
Crystal data
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Refinement
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Data collection: SMART (Bruker, 1998); cell SAINT (Bruker, 1998); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2009); software used to prepare material for publication: SHELXL97.
Supporting information
10.1107/S1600536809014251/hk2666sup1.cif
contains datablocks global, I. DOI:Structure factors: contains datablock I. DOI: 10.1107/S1600536809014251/hk2666Isup2.hkl
The title compound was prepared by the reaction of 1,2-diarylidenehydrazine (2 mmol), Meldrum's acid (5 mmol), HOAc (4 mL) and (S)-1,2-propanediol (8 ml). Upon completion, the reaction mixture was cooled to room temperature, and introduced into water. The solid was collected by washing with water. The combined solid was purified by ethanol.
The Br2, C25, H25, C26, H26A, H26B and H26C atoms were disordered. During the
process, the disordered C and H atoms were refined with occupancies of 0.320 (18) and 0.680 (18), while Br atoms were refined with occupancies of 0.51 (4) and 0.49 (4). H atoms were positioned geometrically, with C-H = 0.93, 0.98, 0.97 and 0.96 Å for aromatic, methine, methylene and methyl H, respectively, and constrained to ride on their parent atoms, with Uiso(H) = xUeq(C), where x = 1.5 for methyl H and x = 1.2 for all other H atoms.Data collection: SMART (Bruker, 1998); cell
SAINT (Bruker, 1998); data reduction: SAINT (Bruker, 1998); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2009); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008).C26H26Br2O6 | Z = 2 |
Mr = 594.29 | F(000) = 600 |
Triclinic, P1 | Dx = 1.557 Mg m−3 |
Hall symbol: -P 1 | Mo Kα radiation, λ = 0.71073 Å |
a = 7.356 (3) Å | Cell parameters from 920 reflections |
b = 12.590 (5) Å | θ = 2.6–25.3° |
c = 14.852 (6) Å | µ = 3.24 mm−1 |
α = 69.787 (6)° | T = 298 K |
β = 87.415 (7)° | Prism, colorless |
γ = 79.243 (6)° | 0.18 × 0.11 × 0.09 mm |
V = 1267.8 (9) Å3 |
Bruker SMART CCD area-detector diffractometer | 4330 independent reflections |
Radiation source: fine-focus sealed tube | 1413 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.060 |
ϕ and ω scans | θmax = 25.0°, θmin = 1.9° |
Absorption correction: multi-scan (SADABS; Sheldrick, 1996) | h = −8→4 |
Tmin = 0.594, Tmax = 0.759 | k = −14→14 |
6454 measured reflections | l = −17→16 |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.073 | H-atom parameters constrained |
wR(F2) = 0.146 | w = 1/[σ2(Fo2) + (0.038P)2] where P = (Fo2 + 2Fc2)/3 |
S = 1.00 | (Δ/σ)max < 0.001 |
4330 reflections | Δρmax = 0.44 e Å−3 |
327 parameters | Δρmin = −0.32 e Å−3 |
Primary atom site location: structure-invariant direct methods |
C26H26Br2O6 | γ = 79.243 (6)° |
Mr = 594.29 | V = 1267.8 (9) Å3 |
Triclinic, P1 | Z = 2 |
a = 7.356 (3) Å | Mo Kα radiation |
b = 12.590 (5) Å | µ = 3.24 mm−1 |
c = 14.852 (6) Å | T = 298 K |
α = 69.787 (6)° | 0.18 × 0.11 × 0.09 mm |
β = 87.415 (7)° |
Bruker SMART CCD area-detector diffractometer | 4330 independent reflections |
Absorption correction: multi-scan (SADABS; Sheldrick, 1996) | 1413 reflections with I > 2σ(I) |
Tmin = 0.594, Tmax = 0.759 | Rint = 0.060 |
6454 measured reflections |
R[F2 > 2σ(F2)] = 0.073 | 327 parameters |
wR(F2) = 0.146 | H-atom parameters constrained |
S = 1.00 | Δρmax = 0.44 e Å−3 |
4330 reflections | Δρmin = −0.32 e Å−3 |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Atom C25 is disordered over two sites, C25 and C25', for which occupation factors were refined and converged to 0.320 (18) and 0.680 (18), respectively. Atom Br2 is disordered over two sites, Br2 and Br2', for which occupation factors were refined and converged to 0.51 (4) and 0.49 (4), respectively |
x | y | z | Uiso*/Ueq | Occ. (<1) | |
Br1 | −0.42012 (15) | 0.06501 (8) | 1.10942 (7) | 0.0968 (5) | |
Br2 | 0.153 (4) | 0.9617 (10) | 0.6351 (8) | 0.129 (4) | 0.51 (4) |
Br2' | 0.052 (4) | 0.9718 (7) | 0.6478 (10) | 0.133 (4) | 0.49 (4) |
O1 | 0.0177 (8) | 0.4886 (5) | 0.8942 (4) | 0.0710 (15) | |
O2 | −0.2101 (7) | 0.5229 (5) | 0.7764 (4) | 0.0800 (16) | |
O3 | 0.2839 (8) | 0.3774 (4) | 0.9013 (4) | 0.0636 (16) | |
O4 | −0.1776 (7) | 0.4473 (4) | 0.6644 (4) | 0.0771 (17) | |
O5 | 0.2593 (9) | 0.2562 (5) | 0.5545 (4) | 0.1010 (19) | |
O6 | 0.4502 (10) | 0.2393 (5) | 0.6762 (4) | 0.0924 (17) | |
C1 | 0.1367 (14) | 0.4189 (7) | 0.8619 (6) | 0.057 (2) | |
C2 | −0.1683 (13) | 0.5300 (8) | 0.8662 (7) | 0.067 (2) | |
C3 | −0.1111 (14) | 0.4561 (7) | 0.7342 (7) | 0.068 (2) | |
C4 | 0.0841 (11) | 0.4000 (6) | 0.7706 (6) | 0.0578 (18) | |
C5 | 0.1176 (11) | 0.2655 (6) | 0.7948 (5) | 0.0652 (19) | |
H5 | 0.2411 | 0.2357 | 0.8250 | 0.078* | |
C6 | 0.1253 (13) | 0.2337 (7) | 0.7058 (6) | 0.084 (2) | |
H6A | 0.0047 | 0.2600 | 0.6740 | 0.100* | |
H6B | 0.1540 | 0.1505 | 0.7239 | 0.100* | |
C7 | 0.2707 (14) | 0.2862 (7) | 0.6355 (7) | 0.082 (2) | |
C8 | 0.2277 (12) | 0.4198 (7) | 0.6086 (6) | 0.081 (2) | |
H8A | 0.3187 | 0.4532 | 0.5636 | 0.098* | |
H8B | 0.1068 | 0.4498 | 0.5772 | 0.098* | |
C9 | 0.2306 (11) | 0.4533 (6) | 0.6926 (6) | 0.069 (2) | |
H9 | 0.3536 | 0.4200 | 0.7227 | 0.083* | |
C10 | −0.2069 (13) | 0.6528 (7) | 0.8562 (6) | 0.106 (3) | |
H10A | −0.3337 | 0.6847 | 0.8365 | 0.158* | |
H10B | −0.1274 | 0.6932 | 0.8089 | 0.158* | |
H10C | −0.1845 | 0.6603 | 0.9167 | 0.158* | |
C11 | −0.2822 (11) | 0.4550 (6) | 0.9417 (5) | 0.076 (2) | |
H11A | −0.4112 | 0.4804 | 0.9241 | 0.114* | |
H11B | −0.2618 | 0.4611 | 1.0029 | 0.114* | |
H11C | −0.2454 | 0.3763 | 0.9454 | 0.114* | |
C12 | −0.0149 (12) | 0.2112 (6) | 0.8688 (6) | 0.0561 (19) | |
C13 | 0.0441 (12) | 0.1672 (6) | 0.9644 (6) | 0.068 (2) | |
H13 | 0.1648 | 0.1672 | 0.9807 | 0.081* | |
C14 | −0.0782 (13) | 0.1233 (6) | 1.0353 (6) | 0.072 (2) | |
H14 | −0.0391 | 0.0948 | 1.0993 | 0.087* | |
C15 | −0.2547 (13) | 0.1210 (6) | 1.0128 (7) | 0.064 (2) | |
C16 | −0.3171 (11) | 0.1642 (6) | 0.9171 (6) | 0.067 (2) | |
H16 | −0.4377 | 0.1640 | 0.9009 | 0.080* | |
C17 | −0.1928 (13) | 0.2069 (6) | 0.8477 (6) | 0.069 (2) | |
H17 | −0.2311 | 0.2340 | 0.7836 | 0.083* | |
C18 | 0.2047 (12) | 0.5829 (6) | 0.6711 (6) | 0.061 (2) | |
C19 | 0.3090 (12) | 0.6205 (7) | 0.7226 (6) | 0.078 (2) | |
H19 | 0.4012 | 0.5686 | 0.7645 | 0.094* | |
C20 | 0.2792 (13) | 0.7354 (7) | 0.7134 (6) | 0.093 (3) | |
H20 | 0.3513 | 0.7617 | 0.7481 | 0.111* | |
C21 | 0.1409 (15) | 0.8104 (7) | 0.6517 (7) | 0.085 (3) | |
C22 | 0.0427 (13) | 0.7738 (7) | 0.5975 (6) | 0.081 (2) | |
H22 | −0.0453 | 0.8257 | 0.5530 | 0.097* | |
C23 | 0.0739 (12) | 0.6600 (7) | 0.6087 (6) | 0.072 (2) | |
H23 | 0.0037 | 0.6344 | 0.5725 | 0.086* | |
C24 | 0.4398 (14) | 0.2316 (9) | 0.5185 (7) | 0.130 (3) | |
H24A | 0.4661 | 0.2965 | 0.4645 | 0.156* | |
H24B | 0.4542 | 0.1642 | 0.4994 | 0.156* | |
C25 | 0.5598 (15) | 0.2100 (9) | 0.6036 (8) | 0.119 (3) | 0.320 (18) |
H25 | 0.5957 | 0.2858 | 0.5774 | 0.142* | 0.320 (18) |
C26 | 0.755 (3) | 0.147 (3) | 0.602 (2) | 0.160 (9) | 0.320 (18) |
H26A | 0.8223 | 0.1402 | 0.6583 | 0.240* | 0.320 (18) |
H26B | 0.8157 | 0.1889 | 0.5459 | 0.240* | 0.320 (18) |
H26C | 0.7525 | 0.0714 | 0.6009 | 0.240* | 0.320 (18) |
C25' | 0.5598 (15) | 0.2100 (9) | 0.6036 (8) | 0.119 (3) | 0.680 (18) |
H25' | 0.6610 | 0.2537 | 0.5858 | 0.142* | 0.680 (18) |
C26' | 0.633 (3) | 0.0856 (14) | 0.6492 (12) | 0.201 (8) | 0.680 (18) |
H26D | 0.6963 | 0.0725 | 0.7082 | 0.302* | 0.680 (18) |
H26E | 0.7168 | 0.0596 | 0.6068 | 0.302* | 0.680 (18) |
H26F | 0.5318 | 0.0441 | 0.6624 | 0.302* | 0.680 (18) |
U11 | U22 | U33 | U12 | U13 | U23 | |
Br1 | 0.0912 (9) | 0.0934 (8) | 0.1038 (8) | −0.0385 (6) | 0.0252 (6) | −0.0232 (6) |
Br2 | 0.173 (10) | 0.061 (2) | 0.150 (3) | −0.016 (4) | −0.045 (5) | −0.030 (2) |
Br2' | 0.173 (10) | 0.047 (2) | 0.170 (4) | −0.003 (4) | −0.049 (6) | −0.027 (2) |
O1 | 0.065 (4) | 0.081 (3) | 0.077 (3) | 0.006 (3) | −0.006 (3) | −0.048 (3) |
O2 | 0.070 (4) | 0.094 (3) | 0.079 (3) | 0.013 (3) | −0.007 (3) | −0.047 (3) |
O3 | 0.058 (4) | 0.055 (3) | 0.076 (4) | −0.003 (3) | −0.012 (3) | −0.022 (3) |
O4 | 0.070 (4) | 0.078 (4) | 0.084 (4) | −0.002 (3) | −0.025 (3) | −0.032 (3) |
O5 | 0.110 (4) | 0.106 (4) | 0.085 (4) | 0.006 (3) | 0.006 (3) | −0.043 (3) |
O6 | 0.106 (4) | 0.095 (4) | 0.086 (4) | −0.005 (3) | 0.007 (3) | −0.049 (3) |
C1 | 0.059 (4) | 0.055 (4) | 0.066 (4) | −0.015 (4) | 0.003 (4) | −0.028 (3) |
C2 | 0.059 (5) | 0.078 (5) | 0.072 (5) | 0.008 (5) | −0.022 (5) | −0.042 (4) |
C3 | 0.075 (4) | 0.060 (4) | 0.074 (4) | −0.017 (4) | −0.005 (4) | −0.027 (4) |
C4 | 0.059 (4) | 0.054 (3) | 0.069 (4) | −0.012 (3) | 0.003 (3) | −0.031 (3) |
C5 | 0.073 (4) | 0.062 (4) | 0.072 (4) | −0.014 (3) | 0.004 (4) | −0.037 (3) |
C6 | 0.095 (4) | 0.070 (4) | 0.087 (4) | −0.008 (4) | 0.002 (4) | −0.032 (4) |
C7 | 0.094 (5) | 0.081 (4) | 0.078 (5) | 0.001 (4) | 0.005 (4) | −0.046 (4) |
C8 | 0.090 (4) | 0.077 (4) | 0.078 (4) | −0.016 (4) | 0.001 (4) | −0.028 (4) |
C9 | 0.080 (4) | 0.060 (4) | 0.074 (4) | −0.018 (3) | 0.006 (4) | −0.028 (3) |
C10 | 0.107 (7) | 0.088 (6) | 0.116 (7) | 0.019 (6) | −0.015 (6) | −0.044 (6) |
C11 | 0.067 (6) | 0.090 (6) | 0.082 (6) | −0.012 (5) | −0.002 (5) | −0.045 (5) |
C12 | 0.055 (4) | 0.054 (4) | 0.072 (4) | −0.016 (4) | 0.001 (4) | −0.035 (3) |
C13 | 0.063 (5) | 0.061 (4) | 0.080 (5) | −0.015 (4) | 0.002 (4) | −0.024 (4) |
C14 | 0.074 (6) | 0.062 (4) | 0.082 (5) | −0.016 (4) | 0.003 (5) | −0.024 (4) |
C15 | 0.063 (5) | 0.056 (4) | 0.079 (5) | −0.024 (4) | 0.004 (5) | −0.026 (4) |
C16 | 0.057 (5) | 0.066 (5) | 0.089 (6) | −0.034 (4) | 0.003 (5) | −0.028 (4) |
C17 | 0.081 (5) | 0.061 (4) | 0.071 (4) | −0.016 (4) | −0.007 (4) | −0.027 (4) |
C18 | 0.072 (4) | 0.053 (4) | 0.064 (4) | −0.016 (4) | −0.003 (4) | −0.026 (3) |
C19 | 0.085 (5) | 0.064 (4) | 0.089 (5) | −0.027 (4) | −0.012 (4) | −0.021 (4) |
C20 | 0.108 (6) | 0.064 (5) | 0.104 (5) | −0.025 (5) | −0.037 (5) | −0.017 (5) |
C21 | 0.106 (6) | 0.045 (4) | 0.101 (6) | −0.021 (5) | −0.022 (5) | −0.013 (4) |
C22 | 0.098 (6) | 0.049 (4) | 0.088 (5) | −0.010 (4) | −0.030 (5) | −0.011 (4) |
C23 | 0.083 (5) | 0.057 (4) | 0.075 (4) | −0.021 (4) | −0.009 (4) | −0.016 (4) |
C24 | 0.113 (6) | 0.148 (6) | 0.118 (6) | 0.004 (6) | 0.001 (6) | −0.044 (5) |
C25 | 0.106 (5) | 0.123 (5) | 0.106 (5) | 0.021 (5) | 0.010 (4) | −0.037 (4) |
C26 | 0.156 (15) | 0.138 (14) | 0.150 (14) | 0.013 (14) | 0.011 (14) | −0.026 (13) |
C25' | 0.106 (5) | 0.123 (5) | 0.106 (5) | 0.021 (5) | 0.010 (4) | −0.037 (4) |
C26' | 0.179 (13) | 0.184 (12) | 0.180 (12) | 0.009 (11) | 0.044 (11) | −0.011 (11) |
Br1—C15 | 1.870 (8) | C11—H11A | 0.9600 |
Br2—C21 | 1.853 (12) | C11—H11B | 0.9600 |
Br2'—C21 | 1.997 (15) | C11—H11C | 0.9600 |
O1—C1 | 1.316 (9) | C12—C17 | 1.374 (10) |
O1—C2 | 1.397 (9) | C12—C13 | 1.391 (10) |
O2—C3 | 1.313 (9) | C13—C14 | 1.386 (9) |
O2—C2 | 1.419 (8) | C13—H13 | 0.9300 |
O3—C1 | 1.193 (9) | C14—C15 | 1.363 (10) |
O4—C3 | 1.213 (9) | C14—H14 | 0.9300 |
O5—C7 | 1.390 (8) | C15—C16 | 1.400 (10) |
O5—C24 | 1.428 (9) | C16—C17 | 1.380 (9) |
O6—C7 | 1.411 (9) | C16—H16 | 0.9300 |
O6—C25 | 1.426 (9) | C17—H17 | 0.9300 |
C1—C4 | 1.534 (10) | C18—C23 | 1.355 (10) |
C2—C10 | 1.475 (10) | C18—C19 | 1.356 (10) |
C2—C11 | 1.525 (10) | C19—C20 | 1.381 (10) |
C3—C4 | 1.510 (11) | C19—H19 | 0.9300 |
C4—C5 | 1.577 (9) | C20—C21 | 1.376 (11) |
C4—C9 | 1.604 (9) | C20—H20 | 0.9300 |
C5—C12 | 1.503 (9) | C21—C22 | 1.347 (10) |
C5—C6 | 1.504 (9) | C22—C23 | 1.360 (10) |
C5—H5 | 0.9800 | C22—H22 | 0.9300 |
C6—C7 | 1.535 (10) | C23—H23 | 0.9300 |
C6—H6A | 0.9700 | C24—C25 | 1.492 (10) |
C6—H6B | 0.9700 | C24—H24A | 0.9700 |
C7—C8 | 1.562 (10) | C24—H24B | 0.9700 |
C8—C9 | 1.450 (9) | C25—C26 | 1.512 (16) |
C8—H8A | 0.9700 | C25—H25 | 0.9800 |
C8—H8B | 0.9700 | C26—H26A | 0.9600 |
C9—C18 | 1.526 (9) | C26—H26B | 0.9600 |
C9—H9 | 0.9800 | C26—H26C | 0.9600 |
C10—H10A | 0.9600 | C26'—H26D | 0.9600 |
C10—H10B | 0.9600 | C26'—H26E | 0.9600 |
C10—H10C | 0.9600 | C26'—H26F | 0.9600 |
C1—O1—C2 | 126.5 (8) | H11A—C11—H11C | 109.5 |
C3—O2—C2 | 126.0 (7) | H11B—C11—H11C | 109.5 |
C7—O5—C24 | 110.3 (8) | C17—C12—C13 | 118.4 (8) |
C7—O6—C25 | 105.9 (8) | C17—C12—C5 | 123.7 (8) |
O3—C1—O1 | 119.5 (9) | C13—C12—C5 | 117.8 (8) |
O3—C1—C4 | 122.3 (9) | C14—C13—C12 | 119.5 (8) |
O1—C1—C4 | 118.1 (8) | C14—C13—H13 | 120.3 |
O1—C2—O2 | 113.3 (7) | C12—C13—H13 | 120.3 |
O1—C2—C10 | 106.9 (8) | C15—C14—C13 | 121.1 (9) |
O2—C2—C10 | 107.4 (7) | C15—C14—H14 | 119.4 |
O1—C2—C11 | 107.3 (7) | C13—C14—H14 | 119.4 |
O2—C2—C11 | 107.5 (7) | C14—C15—C16 | 120.5 (8) |
C10—C2—C11 | 114.8 (8) | C14—C15—Br1 | 120.7 (8) |
O4—C3—O2 | 118.2 (10) | C16—C15—Br1 | 118.8 (7) |
O4—C3—C4 | 122.9 (9) | C17—C16—C15 | 117.4 (8) |
O2—C3—C4 | 118.8 (9) | C17—C16—H16 | 121.3 |
C3—C4—C1 | 114.0 (8) | C15—C16—H16 | 121.3 |
C3—C4—C5 | 111.8 (7) | C12—C17—C16 | 123.0 (9) |
C1—C4—C5 | 106.2 (6) | C12—C17—H17 | 118.5 |
C3—C4—C9 | 110.4 (7) | C16—C17—H17 | 118.5 |
C1—C4—C9 | 104.9 (6) | C23—C18—C19 | 119.1 (8) |
C5—C4—C9 | 109.2 (6) | C23—C18—C9 | 123.1 (8) |
C12—C5—C6 | 114.8 (6) | C19—C18—C9 | 117.7 (8) |
C12—C5—C4 | 111.2 (6) | C18—C19—C20 | 120.4 (9) |
C6—C5—C4 | 112.0 (6) | C18—C19—H19 | 119.8 |
C12—C5—H5 | 106.0 | C20—C19—H19 | 119.8 |
C6—C5—H5 | 106.0 | C21—C20—C19 | 118.7 (9) |
C4—C5—H5 | 106.0 | C21—C20—H20 | 120.6 |
C5—C6—C7 | 112.4 (7) | C19—C20—H20 | 120.6 |
C5—C6—H6A | 109.1 | C22—C21—C20 | 120.7 (8) |
C7—C6—H6A | 109.1 | C22—C21—Br2 | 126.7 (9) |
C5—C6—H6B | 109.1 | C20—C21—Br2 | 111.0 (10) |
C7—C6—H6B | 109.1 | C22—C21—Br2' | 115.6 (9) |
H6A—C6—H6B | 107.9 | C20—C21—Br2' | 123.3 (9) |
O5—C7—O6 | 108.0 (7) | Br2—C21—Br2' | 22.3 (3) |
O5—C7—C6 | 107.4 (8) | C21—C22—C23 | 119.1 (9) |
O6—C7—C6 | 110.3 (8) | C21—C22—H22 | 120.4 |
O5—C7—C8 | 110.5 (7) | C23—C22—H22 | 120.4 |
O6—C7—C8 | 111.3 (8) | C18—C23—C22 | 121.8 (9) |
C6—C7—C8 | 109.1 (7) | C18—C23—H23 | 119.1 |
C9—C8—C7 | 111.6 (7) | C22—C23—H23 | 119.1 |
C9—C8—H8A | 109.3 | O5—C24—C25 | 101.7 (8) |
C7—C8—H8A | 109.3 | O5—C24—H24A | 111.4 |
C9—C8—H8B | 109.3 | C25—C24—H24A | 111.4 |
C7—C8—H8B | 109.3 | O5—C24—H24B | 111.4 |
H8A—C8—H8B | 108.0 | C25—C24—H24B | 111.4 |
C8—C9—C18 | 114.6 (7) | H24A—C24—H24B | 109.3 |
C8—C9—C4 | 112.0 (6) | O6—C25—C24 | 109.5 (9) |
C18—C9—C4 | 109.8 (6) | O6—C25—C26 | 133.7 (15) |
C8—C9—H9 | 106.6 | C24—C25—C26 | 116.0 (13) |
C18—C9—H9 | 106.6 | O6—C25—H25 | 93.0 |
C4—C9—H9 | 106.6 | C24—C25—H25 | 93.0 |
C2—C10—H10A | 109.5 | C26—C25—H25 | 93.0 |
C2—C10—H10B | 109.5 | C25—C26—H26A | 109.5 |
H10A—C10—H10B | 109.5 | C25—C26—H26B | 109.5 |
C2—C10—H10C | 109.5 | H26A—C26—H26B | 109.5 |
H10A—C10—H10C | 109.5 | C25—C26—H26C | 109.5 |
H10B—C10—H10C | 109.5 | H26A—C26—H26C | 109.5 |
C2—C11—H11A | 109.5 | H26B—C26—H26C | 109.5 |
C2—C11—H11B | 109.5 | H26D—C26'—H26E | 109.5 |
H11A—C11—H11B | 109.5 | H26D—C26'—H26F | 109.5 |
C2—C11—H11C | 109.5 | H26E—C26'—H26F | 109.5 |
D—H···A | D—H | H···A | D···A | D—H···A |
C23—H23···O5i | 0.93 | 2.60 | 3.286 (2) | 131 |
Symmetry code: (i) −x, −y+1, −z+1. |
Experimental details
Crystal data | |
Chemical formula | C26H26Br2O6 |
Mr | 594.29 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 298 |
a, b, c (Å) | 7.356 (3), 12.590 (5), 14.852 (6) |
α, β, γ (°) | 69.787 (6), 87.415 (7), 79.243 (6) |
V (Å3) | 1267.8 (9) |
Z | 2 |
Radiation type | Mo Kα |
µ (mm−1) | 3.24 |
Crystal size (mm) | 0.18 × 0.11 × 0.09 |
Data collection | |
Diffractometer | Bruker SMART CCD area-detector diffractometer |
Absorption correction | Multi-scan (SADABS; Sheldrick, 1996) |
Tmin, Tmax | 0.594, 0.759 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 6454, 4330, 1413 |
Rint | 0.060 |
(sin θ/λ)max (Å−1) | 0.595 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.073, 0.146, 1.00 |
No. of reflections | 4330 |
No. of parameters | 327 |
No. of restraints | ? |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.44, −0.32 |
Computer programs: SMART (Bruker, 1998), SAINT (Bruker, 1998), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2009).
D—H···A | D—H | H···A | D···A | D—H···A |
C23—H23···O5i | 0.93 | 2.60 | 3.286 (2) | 131 |
Symmetry code: (i) −x, −y+1, −z+1. |
Acknowledgements
We thank the Natural Science Foundation of China (grant No. 20672090) and the Natural Science Foundation of Jiangsu Province (grant No. BK2006033).
References
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This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
Over the past few decades, Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) (Tietze & Beifuss, 1993; Tietze et al., 2001) has been used as a versatile organic reagent (Ramachary et al., 2003; Muller et al., 2005) and its derivatives are very useful building blocks in synthetic organic chemistry (Davidson & Bernhard, 1948; Meldrum, 1908). Spirocyclic compounds including a Meldrum's acid unit are attractive intermediates in the syntheses of natural products and in medicinal chemistry. Thus, the synthesis of new highly substituted spiro ring system with a Meldrum's acid unit has attracted widespread attention (Ramachary & Barbas, 2004; Chande & Khanwelkar, 2005). We report herein the crystal structure of the title compound.
In the molecule of the title compound (Fig. 1), the bond lengths (Allen et al., 1987) and angles are within normal ranges. Ring A (C4-C9) is not planar, having total puckering amplitude, QT, of 0.576 (3) Å and chair conformation [ϕ = -150.30 (3) and θ = 3.77 (3) °] (Cremer & Pople, 1975). Rings D (C12-C17) and E (C18-C23) are, of course, planar, and they are oriented at a dihedral angle of D/E = 77.21 (3)°. Rings B (O1/O2/C1-C4) and C (O5/O6/C7/C24/C25) adopt envelope conformations, with atoms C2 and O5 displaced by -0.184 (3) and -0.291 (3) Å from the planes of the other rings atoms.
In the crystal structure, weak intermolecular C-H···O interactions (Table 1) link the molecules into centrosymmetric dimers forming R22(14) ring motifs (Fig. 2) (Bernstein et al., 1995), in which they may be effective in the stabilization of the structure.