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organic compounds\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Journal logoCRYSTALLOGRAPHIC
COMMUNICATIONS
ISSN: 2056-9890
Volume 66| Part 12| December 2010| Page o3320
https://doi.org/10.1107/S1600536810048324

N-(4-Chloro­pyridin-2-yl)-N-(4-methyl­phenyl­sulfon­yl)acetamide

Stefanie Bühler,a Dieter Schollmeyer,b Wolfgang Albrechtc and Stefan Laufera*

aEberhard-Karls-University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany, bUniversity Mainz, Institute of Organic Chemistry, Duesbergweg 10-14, 55099 Mainz, Germany, and cc-a-i-r biosciences GmbH, Paul-Ehrlich-Str. 15, 72076 Tübingen, Germany
*Correspondence e-mail: stefan.laufer@uni-tuebingen.de

(Received 18 November 2010; accepted 19 November 2010; online 27 November 2010)

The crystal structure of the title compound, C14H13ClN2O3S, features a three-dimensional network stabilized by inter­molecular C—H⋯O hydrogen bonds between the mol­ecules. The 4-methyl­phenyl­sulfonyl ring forms a dihedral angle of 30.6 (1)° with the 4-chloro­pyridine ring.

Related literature

For the biological activity of 2-alkyl­amino­pyridinyl or 2-acyl­amino­pyridinyl imidazole derivatives as p38α MAPK inhibitors, see: Laufer et al. (2008[Laufer, S. A., Hauser, D. R. J., Domeyer, D. M., Kinkel, K. & Liedtke, A. J. (2008). J. Med. Chem. 51, 4122-4149.], 2010[Laufer, S., Hauser, D., Stegmiller, T., Bracht, C., Ruff, K., Schattel, V., Albrecht, W. & Koch, P. (2010). Bioorg. Med. Chem. Lett. 20, 6671-6675.]); Ziegler et al. (2009[Ziegler, K., Hauser, D. R. J., Unger, A., Albrecht, W. & Laufer, S. A. (2009). ChemMedChem, 4, 1939-1948.]). For general background to protecting groups, see: Kocieński (2005[Kocieński, P. J. (2005). Protecting Groups, 3rd ed. Stuttgart: Georg Thieme Verlag.]). For the preparation of the N-protected 4-chloro­pyridine, see: Berliner & Belecki (2005[Berliner, M. A. & Belecki, K. (2005). J. Org. Chem. 70, 9618-9621.]); Sciotti et al. (2005[Sciotti, R. J., Starr, J. T., Richardson, C., Rewcastle, G. W., Palmer, B. D., Sutherland, H. S., Spicer, J. A. & Chen, H. (2005). PCT Int. Appl. WO 2005089763, 100 pp.]); Shi & Wang (2002[Shi, M. & Wang, C.-J. (2002). Tetrahedron Asymmetry, 13, 2161-2166.]).

[Scheme 1]

Experimental

Crystal data

  • C14H13ClN2O3S

  • Mr = 324.77

  • Orthorhombic, P b c a

  • a = 12.578 (2) Å

  • b = 7.5460 (8) Å

  • c = 30.194 (3) Å

  • V = 2865.7 (7) Å3

  • Z = 8

  • Cu Kα radiation

  • μ = 3.83 mm−1

  • T = 193 K

  • 0.35 × 0.35 × 0.25 mm
Data collection

  • Enraf–Nonius CAD-4 diffractometer

  • Absorption correction: ψ scan (CORINC; Dräger & Gattow, 1971[Dräger, M. & Gattow, G. (1971). Acta Chem. Scand. 25, 761-762.]) Tmin = 0.872, Tmax = 0.997

  • 5291 measured reflections

  • 2713 independent reflections

  • 2412 reflections with I > 2σ(I)

  • Rint = 0.079

  • 3 standard reflections every 60 min intensity decay: 2%
Refinement

  • R[F2 > 2σ(F2)] = 0.049

  • wR(F2) = 0.129

  • S = 1.13

  • 2713 reflections

  • 193 parameters

  • H-atom parameters constrained

  • Δρmax = 0.44 e Å−3

  • Δρmin = −0.33 e Å−3

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A D—H H⋯A D⋯A D—H⋯A
C3—H3⋯O13i 0.95 2.46 3.404 (3) 174
C14—H14B⋯O10ii 0.98 2.50 3.170 (4) 126
C18—H18⋯O9iii 0.95 2.46 3.334 (3) 152
Symmetry codes: (i) [-x+1, y-{\script{1\over 2}}, -z+{\script{1\over 2}}]; (ii) [-x+{\script{1\over 2}}, y+{\script{1\over 2}}, z]; (iii) -x+1, -y+1, -z+1.

Data collection: CAD-4 Software (Enraf–Nonius, 1989[Enraf-Nonius (1989). CAD-4 Software. Enraf-Nonius, Delft, The Netherlands.]); cell refinement: CAD-4 Software; data reduction: CORINC (Dräger & Gattow, 1971[Dräger, M. & Gattow, G. (1971). Acta Chem. Scand. 25, 761-762.]); program(s) used to solve structure: SIR97 (Altomare et al., 1999[Altomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Polidori, G. & Spagna, R. (1999). J. Appl. Cryst. 32, 115-119.]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008[Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.]); molecular graphics: PLATON (Spek, 2009[Spek, A. L. (2009). Acta Cryst. D65, 148-155.]); software used to prepare material for publication: PLATON.

Supporting information

Crystal structure: contains datablocks I, global. DOI: https://doi.org/10.1107/S1600536810048324/bt5410sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S1600536810048324/bt5410Isup2.hkl

checkCIF report


Comment top

In recent years, compounds with the 2-aminopyridine moiety exhibited interesting biological activities like the 2-alkylaminopyridinyl or 2-acylaminopyridinyl imidazole derivatives as p38α mitogen-activated protein kinase (p38α MAPK) inhibitors. The N-protected 4-chloropyridine is an important precursor to block the nucleophilic and basic properties of the amino-group in the C2 position of the pyridine ring. The analysis of the crystal structure shows that the aromatic C18—H-group of the 4-chloropyridine ring of one molecule interacts with the oxygen-atom O9 of the sulfonyl group of another molecule related to the first by centre of symmetry with a distance of H18···O9 2.47 Å. Furthermore, the aromatic C3—H group of the 4-methylphenylsulfonyl ring forms an intermolecular C3—H3···O13_a hydrogen bond (2.46 Å) to the oxygen atom O13 of the acetamide moiety of a third molecule. An additional hydrogen bond was observed between the methyl-group C14—H3 of the acetamide moiety and the oxygen-atom O10 of the sulfonyl group of a further molecule, whereas the O10···H14B distance is 2.50 Å. The dihedral angle between the 4-methylphenylsulfonyl ring and the 4-chloropyridine ring is 30.6 (1)°.

Related literature top

For the biological activity of 2-alkylaminopyridinyl or 2-acylaminopyridinyl imidazole derivatives as p38α MAPK inhibitors, see: Laufer et al. (2010); Ziegler et al. (2009); Laufer et al. (2008). For general background to protecting groups, see: Kocieński (2005). For the preparation of the N-protected 4-chloropyridine, see: Berliner & Belecki (2005); Sciotti et al. (2005); Shi et al. (2002).

Experimental top

Synthesis of chloromethyl methyl ether as a solution of toluene: To a solution of dimethoxymethane (44.3 ml, 0.50 mol, 1 equiv) and Zn(OAc)2 (9.2 mg, 0.01%) in toluene (133 ml) was added acetyl chloride (35.5 ml, 0.50 mol, 1 equiv). During the next 15 min, the reaction mixture warmed slowly at T = 318 K, and then cooled to ambient temperature over 3 h. The progress was again monitored until NMR analysis indicated complete conversion. The solution of MOMCl in toluene prepared using this stoichiometry is approximately 2.1 M.

Synthesis of N-(4-chloropyridin-2-yl)-4-methylbenzenesulfonamide: 2-Amino- 4-chloropyridine (20.1 g, 156 mmol. 1 equiv) and 4-toluenesulfonyl chloride (32.4 g, 168 mmol, 1.1 equiv) were dissolved in dry pyridine (70 ml) and heated at T = 353 K for 5 h. After cooling to room temperature, water was added and the compound N-(4-chloropyridin-2-yl)-4-methylbenzenesulfonamide dropped down as a beige solid with high analytical quality, which was filtered off and washed with water (30.6 g, 70.8%).

Synthesis of N-(4-chloropyridin-2-yl)-N-tosylacetamide: Under a nitrogen atmosphere, N-(4-chloropyridin-2-yl)-4-methylbenzene-sulfonamide (20.0 g, 71 mmol, 1 equiv) was added to a suspension of NaH (4.2 g, 104 mmol, 1.5 equiv) in anhydrous THF (200 ml) with stirring. The resulting reaction mixture was stirred for 20 min, and then the solution of methoxymethyl chloride in toluene (52.1 ml, 1.5 equiv) was slowly added. The mixture was stirred for 3 h and then an aqueous saturated solution of NH4Cl was added. After separation, the aqueous layer was extracted with EtOAc, dried over Na2SO4 and evaporated. After treatment with hexane, the compound N-(4-chloropyridin-2-yl)- N-(methoxymethyl)-4-methylbenzenesulfonamide was obtained as the main product of the reaction (15.8 g, 69.7%) and dropped down as a pale yellow solid, whereas the compound N-(4-chloropyridin-2-yl)-N-tosylacetamide was isolated from the filtrate as the byproduct (15.4%). Suitable crystals of the byproduct N-(4-chloropyridin-2-yl)-N-tosylacetamide for X-ray were obtained by slow evaporation at T = 298 K of a solution mixture of EtOAc/hexane.

Refinement top

Hydrogen atoms were placed at calculated positions with C—H = 0.95 Å (aromatic) or 0.98–0.99 Å (sp3 C-atom) and refined in the riding-model approximation with isotropic displacement parameters (set at 1.2–1.5 times of the Ueq of the parent atom).

Structure description top

In recent years, compounds with the 2-aminopyridine moiety exhibited interesting biological activities like the 2-alkylaminopyridinyl or 2-acylaminopyridinyl imidazole derivatives as p38α mitogen-activated protein kinase (p38α MAPK) inhibitors. The N-protected 4-chloropyridine is an important precursor to block the nucleophilic and basic properties of the amino-group in the C2 position of the pyridine ring. The analysis of the crystal structure shows that the aromatic C18—H-group of the 4-chloropyridine ring of one molecule interacts with the oxygen-atom O9 of the sulfonyl group of another molecule related to the first by centre of symmetry with a distance of H18···O9 2.47 Å. Furthermore, the aromatic C3—H group of the 4-methylphenylsulfonyl ring forms an intermolecular C3—H3···O13_a hydrogen bond (2.46 Å) to the oxygen atom O13 of the acetamide moiety of a third molecule. An additional hydrogen bond was observed between the methyl-group C14—H3 of the acetamide moiety and the oxygen-atom O10 of the sulfonyl group of a further molecule, whereas the O10···H14B distance is 2.50 Å. The dihedral angle between the 4-methylphenylsulfonyl ring and the 4-chloropyridine ring is 30.6 (1)°.

For the biological activity of 2-alkylaminopyridinyl or 2-acylaminopyridinyl imidazole derivatives as p38α MAPK inhibitors, see: Laufer et al. (2010); Ziegler et al. (2009); Laufer et al. (2008). For general background to protecting groups, see: Kocieński (2005). For the preparation of the N-protected 4-chloropyridine, see: Berliner & Belecki (2005); Sciotti et al. (2005); Shi et al. (2002).

Computing details top

Data collection: CAD-4 Software (Enraf–Nonius, 1989); cell refinement: CAD-4 Software (Enraf–Nonius, 1989); data reduction: CORINC (Dräger & Gattow, 1971); program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: PLATON (Spek, 2009); software used to prepare material for publication: PLATON (Spek, 2009).

Figures top
[Figure 1] Fig. 1. View of compound I. Displacement ellipsoids are drawn at the 50% probability level.
N-(4-Chloropyridin-2-yl)-N-(4-methylphenylsulfonyl)acetamide top
Crystal data top
C14H13ClN2O3SF(000) = 1344
Mr = 324.77Dx = 1.506 Mg m−3
Orthorhombic, PbcaCu Kα radiation, λ = 1.54178 Å
Hall symbol: -P 2ac 2abCell parameters from 25 reflections
a = 12.578 (2) Åθ = 65–69°
b = 7.5460 (8) ŵ = 3.83 mm−1
c = 30.194 (3) ÅT = 193 K
V = 2865.7 (7) Å3Block, colourless
Z = 80.35 × 0.35 × 0.25 mm
Data collection top
Enraf–Nonius CAD-4
diffractometer		2412 reflections with I > 2σ(I)
Radiation source: rotating anodeRint = 0.079
Graphite monochromatorθmax = 70.0°, θmin = 2.9°
ω/2θ scansh = −15→15
Absorption correction: ψ scan
(CORINC; Dräger & Gattow, 1971)		k = 0→9
Tmin = 0.872, Tmax = 0.997l = 0→36
5291 measured reflections3 standard reflections every 60 min
2713 independent reflections intensity decay: 2%
Refinement top
Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.049H-atom parameters constrained
wR(F2) = 0.129 w = 1/[σ2(Fo2) + (0.0592P)2 + 0.6955P]
where P = (Fo2 + 2Fc2)/3
S = 1.13(Δ/σ)max = 0.001
2713 reflectionsΔρmax = 0.44 e Å−3
193 parametersΔρmin = −0.33 e Å−3
0 restraintsExtinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methodsExtinction coefficient: 0.00129 (16)
Crystal data top
C14H13ClN2O3SV = 2865.7 (7) Å3
Mr = 324.77Z = 8
Orthorhombic, PbcaCu Kα radiation
a = 12.578 (2) ŵ = 3.83 mm−1
b = 7.5460 (8) ÅT = 193 K
c = 30.194 (3) Å0.35 × 0.35 × 0.25 mm
Data collection top
Enraf–Nonius CAD-4
diffractometer		2412 reflections with I > 2σ(I)
Absorption correction: ψ scan
(CORINC; Dräger & Gattow, 1971)		Rint = 0.079
Tmin = 0.872, Tmax = 0.9973 standard reflections every 60 min
5291 measured reflections intensity decay: 2%
2713 independent reflections
Refinement top
R[F2 > 2σ(F2)] = 0.0490 restraints
wR(F2) = 0.129H-atom parameters constrained
S = 1.13Δρmax = 0.44 e Å−3
2713 reflectionsΔρmin = −0.33 e Å−3
193 parameters
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
Cl10.26049 (7)0.59127 (8)0.519895 (18)0.0474 (2)
C10.55234 (19)0.0478 (3)0.36074 (7)0.0279 (5)
C20.5457 (2)−0.0380 (3)0.31992 (7)0.0299 (5)
H20.4787−0.07020.30790.036*
C30.6385 (2)−0.0751 (3)0.29725 (7)0.0358 (6)
H30.6346−0.13370.26940.043*
C40.7371 (2)−0.0290 (3)0.31410 (8)0.0374 (6)
C50.7421 (2)0.0548 (3)0.35535 (8)0.0379 (5)
H50.80930.08510.36750.046*
C60.6503 (2)0.0940 (3)0.37862 (7)0.0342 (5)
H60.65420.15190.40650.041*
C70.8367 (3)−0.0685 (4)0.28847 (11)0.0545 (8)
H7A0.8945−0.09630.30910.082*
H7B0.85620.03510.27070.082*
H7C0.8243−0.17000.26890.082*
S80.43683 (5)0.09319 (7)0.390620 (16)0.0289 (2)
O90.46215 (17)0.0989 (2)0.43669 (5)0.0394 (4)
O100.35394 (15)−0.0198 (2)0.37556 (5)0.0390 (4)
N110.40466 (17)0.3056 (2)0.37834 (6)0.0295 (4)
C120.38183 (19)0.3544 (3)0.33447 (7)0.0314 (5)
O130.37972 (16)0.2443 (2)0.30578 (5)0.0404 (4)
C140.3638 (3)0.5483 (3)0.32551 (8)0.0451 (6)
H14A0.43240.60970.32450.068*
H14B0.32010.59900.34920.068*
H14C0.32730.56230.29710.068*
C150.41589 (19)0.4361 (3)0.41287 (6)0.0270 (5)
C160.33884 (19)0.4476 (3)0.44486 (6)0.0278 (4)
H160.27870.37130.44470.033*
C170.3522 (2)0.5750 (3)0.47748 (7)0.0305 (5)
C180.4390 (2)0.6871 (3)0.47593 (8)0.0373 (6)
H180.44880.77730.49750.045*
C190.5105 (2)0.6634 (3)0.44216 (8)0.0389 (6)
H190.57040.74000.44110.047*
N200.50149 (17)0.5390 (3)0.41048 (6)0.0343 (4)
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
Cl10.0655 (5)0.0449 (4)0.0320 (3)0.0135 (3)0.0132 (3)−0.0045 (2)
C10.0379 (13)0.0247 (10)0.0211 (9)0.0010 (9)−0.0010 (8)0.0012 (8)
C20.0408 (13)0.0237 (10)0.0251 (10)−0.0023 (10)−0.0025 (9)−0.0026 (8)
C30.0527 (15)0.0273 (10)0.0274 (10)0.0045 (11)0.0038 (11)−0.0014 (8)
C40.0440 (15)0.0286 (11)0.0396 (11)0.0089 (11)0.0078 (11)0.0102 (9)
C50.0349 (13)0.0353 (12)0.0436 (12)0.0010 (10)−0.0063 (11)0.0064 (10)
C60.0455 (15)0.0296 (11)0.0275 (10)0.0013 (10)−0.0086 (10)−0.0012 (8)
C70.0509 (18)0.0453 (15)0.0675 (18)0.0124 (14)0.0187 (16)0.0125 (13)
S80.0396 (4)0.0244 (3)0.0225 (3)0.0014 (2)0.0028 (2)0.00126 (17)
O90.0628 (12)0.0318 (8)0.0236 (8)0.0098 (8)0.0048 (8)0.0027 (6)
O100.0411 (10)0.0320 (8)0.0438 (9)−0.0061 (8)0.0062 (7)0.0011 (7)
N110.0382 (11)0.0257 (9)0.0244 (8)0.0029 (8)0.0009 (7)−0.0017 (7)
C120.0326 (12)0.0350 (11)0.0265 (10)0.0013 (10)−0.0022 (9)0.0019 (9)
O130.0564 (11)0.0390 (9)0.0257 (7)0.0014 (9)−0.0055 (7)−0.0002 (7)
C140.0530 (16)0.0427 (14)0.0397 (12)0.0063 (13)0.0026 (12)0.0058 (11)
C150.0336 (11)0.0252 (10)0.0221 (9)0.0050 (9)−0.0035 (8)0.0013 (7)
C160.0327 (11)0.0256 (10)0.0252 (9)0.0019 (9)−0.0014 (8)0.0014 (8)
C170.0397 (13)0.0281 (10)0.0235 (9)0.0091 (10)−0.0021 (9)0.0020 (8)
C180.0520 (15)0.0272 (11)0.0327 (11)0.0039 (11)−0.0129 (10)−0.0039 (9)
C190.0379 (13)0.0321 (12)0.0467 (13)−0.0030 (11)−0.0089 (11)0.0011 (10)
N200.0350 (11)0.0315 (10)0.0364 (10)0.0005 (9)−0.0008 (8)0.0025 (8)
Geometric parameters (Å, º) top
Cl1—C171.728 (2)S8—N111.6942 (18)
C1—C61.390 (3)N11—C121.405 (3)
C1—C21.395 (3)N11—C151.441 (3)
C1—S81.744 (2)C12—O131.201 (3)
C2—C31.382 (4)C12—C141.505 (3)
C2—H20.9500C14—H14A0.9800
C3—C41.385 (4)C14—H14B0.9800
C3—H30.9500C14—H14C0.9800
C4—C51.398 (4)C15—N201.329 (3)
C4—C71.502 (4)C15—C161.371 (3)
C5—C61.384 (4)C16—C171.387 (3)
C5—H50.9500C16—H160.9500
C6—H60.9500C17—C181.381 (4)
C7—H7A0.9800C18—C191.371 (4)
C7—H7B0.9800C18—H180.9500
C7—H7C0.9800C19—N201.345 (3)
S8—O101.4213 (19)C19—H190.9500
S8—O91.4276 (16)
C6—C1—C2120.8 (2)N11—S8—C1105.75 (10)
C6—C1—S8119.24 (16)C12—N11—C15121.53 (18)
C2—C1—S8119.92 (18)C12—N11—S8120.24 (15)
C3—C2—C1118.8 (2)C15—N11—S8117.69 (14)
C3—C2—H2120.6O13—C12—N11120.2 (2)
C1—C2—H2120.6O13—C12—C14122.7 (2)
C2—C3—C4121.5 (2)N11—C12—C14117.1 (2)
C2—C3—H3119.2C12—C14—H14A109.5
C4—C3—H3119.2C12—C14—H14B109.5
C3—C4—C5118.8 (2)H14A—C14—H14B109.5
C3—C4—C7120.5 (2)C12—C14—H14C109.5
C5—C4—C7120.7 (3)H14A—C14—H14C109.5
C6—C5—C4120.8 (2)H14B—C14—H14C109.5
C6—C5—H5119.6N20—C15—C16125.0 (2)
C4—C5—H5119.6N20—C15—N11116.06 (19)
C5—C6—C1119.3 (2)C16—C15—N11118.9 (2)
C5—C6—H6120.4C15—C16—C17117.3 (2)
C1—C6—H6120.4C15—C16—H16121.4
C4—C7—H7A109.5C17—C16—H16121.4
C4—C7—H7B109.5C18—C17—C16119.8 (2)
H7A—C7—H7B109.5C18—C17—Cl1120.60 (17)
C4—C7—H7C109.5C16—C17—Cl1119.64 (19)
H7A—C7—H7C109.5C19—C18—C17117.6 (2)
H7B—C7—H7C109.5C19—C18—H18121.2
O10—S8—O9119.57 (11)C17—C18—H18121.2
O10—S8—N11108.79 (10)N20—C19—C18124.4 (2)
O9—S8—N11103.77 (9)N20—C19—H19117.8
O10—S8—C1109.13 (10)C18—C19—H19117.8
O9—S8—C1108.91 (12)C15—N20—C19115.9 (2)
C6—C1—C2—C3−0.5 (3)O9—S8—N11—C153.9 (2)
S8—C1—C2—C3−178.90 (16)C1—S8—N11—C15−110.65 (18)
C1—C2—C3—C4−0.1 (3)C15—N11—C12—O13175.1 (2)
C2—C3—C4—C51.0 (3)S8—N11—C12—O133.8 (3)
C2—C3—C4—C7−179.1 (2)C15—N11—C12—C14−3.2 (3)
C3—C4—C5—C6−1.2 (4)S8—N11—C12—C14−174.53 (19)
C7—C4—C5—C6178.9 (2)C12—N11—C15—N20−69.5 (3)
C4—C5—C6—C10.6 (3)S8—N11—C15—N20102.1 (2)
C2—C1—C6—C50.3 (3)C12—N11—C15—C16109.6 (2)
S8—C1—C6—C5178.69 (17)S8—N11—C15—C16−78.8 (2)
C6—C1—S8—O10−158.12 (17)N20—C15—C16—C17−0.8 (3)
C2—C1—S8—O1020.3 (2)N11—C15—C16—C17−179.85 (18)
C6—C1—S8—O9−26.0 (2)C15—C16—C17—C181.9 (3)
C2—C1—S8—O9152.42 (17)C15—C16—C17—Cl1−177.71 (16)
C6—C1—S8—N1185.00 (19)C16—C17—C18—C19−1.6 (3)
C2—C1—S8—N11−96.60 (19)Cl1—C17—C18—C19178.00 (18)
O10—S8—N11—C12−56.1 (2)C17—C18—C19—N200.2 (4)
O9—S8—N11—C12175.60 (19)C16—C15—N20—C19−0.5 (3)
C1—S8—N11—C1261.0 (2)N11—C15—N20—C19178.49 (19)
O10—S8—N11—C15132.24 (18)C18—C19—N20—C150.9 (3)
Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
C3—H3···O13i0.952.463.404 (3)174
C14—H14B···O10ii0.982.503.170 (4)126
C18—H18···O9iii0.952.463.334 (3)152
Symmetry codes: (i) −x+1, y−1/2, −z+1/2; (ii) −x+1/2, y+1/2, z; (iii) −x+1, −y+1, −z+1.

Experimental details

Crystal data
Chemical formulaC14H13ClN2O3S
Mr324.77
Crystal system, space groupOrthorhombic, Pbca
Temperature (K)193
a, b, c (Å)12.578 (2), 7.5460 (8), 30.194 (3)
V (Å3)2865.7 (7)
Z8
Radiation typeCu Kα
µ (mm−1)3.83
Crystal size (mm)0.35 × 0.35 × 0.25
Data collection
DiffractometerEnraf–Nonius CAD-4
Absorption correctionψ scan
(CORINC; Dräger & Gattow, 1971)
Tmin, Tmax0.872, 0.997
No. of measured, independent and
observed [I > 2σ(I)] reflections		5291, 2713, 2412
Rint0.079
(sin θ/λ)max (Å−1)0.609
Refinement
R[F2 > 2σ(F2)], wR(F2), S 0.049, 0.129, 1.13
No. of reflections2713
No. of parameters193
H-atom treatmentH-atom parameters constrained
Δρmax, Δρmin (e Å−3)0.44, −0.33

Computer programs: CAD-4 Software (Enraf–Nonius, 1989), CORINC (Dräger & Gattow, 1971), SIR97 (Altomare et al., 1999), SHELXL97 (Sheldrick, 2008), PLATON (Spek, 2009).

Hydrogen-bond geometry (Å, º) top
D—H···AD—HH···AD···AD—H···A
C3—H3···O13i0.952.463.404 (3)174
C14—H14B···O10ii0.982.503.170 (4)126
C18—H18···O9iii0.952.463.334 (3)152
Symmetry codes: (i) −x+1, y−1/2, −z+1/2; (ii) −x+1/2, y+1/2, z; (iii) −x+1, −y+1, −z+1.
 

Acknowledgements

The authors would like to thank the Federal Ministry of Education and Research, Germany, Merckle GmbH, Ulm, Germany and Fonds der Chemischen Industrie, Germany for their generous support of this work.

References

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This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

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ISSN: 2056-9890
Volume 66| Part 12| December 2010| Page o3320
https://doi.org/10.1107/S1600536810048324
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