organic compounds
2-Chloro-N-ethyl-9-isopropyl-9H-purin-6-amine
aDepartment of Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Nám. T. G. Masaryka 275, Zlín, 762 72, Czech Republic, and bDepartment of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, Brno-Bohunice, 625 00, Czech Republic
*Correspondence e-mail: rvicha@ft.utb.cz
In the title compound, C10H14ClN5, the purine ring system is essentially planar, with an r.m.s. deviation from the least-squares plane defined by the nine constituent atoms of 0.0063 (11) Å. In the crystal, molecules are linked by weak N—H⋯N and C—H⋯π interactions.
Related literature
For the synthesis, see: Fiorini & Abel (1998). For related structures, see: Kubicki & Codding (2001); Rouchal et al. (2009a,b, 2010). For other related literature, see: Legraverend & Grierson (2006).
Experimental
Crystal data
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Refinement
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Data collection: CrysAlis CCD (Oxford Diffraction, 2009); cell CrysAlis RED (Oxford Diffraction, 2009); data reduction: CrysAlis RED; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997) and Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXL97.
Supporting information
10.1107/S1600536812035933/lx2254sup1.cif
contains datablocks global, I. DOI:Structure factors: contains datablock I. DOI: 10.1107/S1600536812035933/lx2254Isup2.hkl
Supporting information file. DOI: 10.1107/S1600536812035933/lx2254Isup3.cml
The title compound was prepared according to slightly modified literature procedure (Fiorini & Abel, 1998). 2,6-Dichloro-9-isopropyl-9H-purine (100 mg, 0.43 mmol) and ethylamine hydrochloride (37 mg, 0.45 mmol) were dissolved in the mixture of DMF (3 cm3) and triethylamine (87 mg, 0.86 mmol). The resulting solution was stirred at 90 °C for 3 h. Subsequently, the mixture was diluted with water and extracted with ethyl acetate (6 × 10 cm3). Combined organic layers were washed twice with brine, dried over Na2SO4 and evaporated in vacuum. Crystallization of the crude product from diethyl ether at room temperature provided desired compound as colorless crystals (67 mg, 65%, mp 390–393 K) suitable for X-ray diffraction analysis.
All carbon bound H atoms were placed at calculated positions and were refined as riding with their Uiso set to either 1.2Ueq or 1.5Ueq (methyl) of the respective carrier atoms. The positions of methyl H atoms were optimized rotationally. Nitrogen bound H atom was located in a difference Fourier map and refined freely.
Data collection: CrysAlis CCD (Oxford Diffraction, 2009); cell
CrysAlis RED (Oxford Diffraction, 2009); data reduction: CrysAlis RED (Oxford Diffraction, 2009); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997) and Mercury (Macrae et al., 2008); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008).Fig. 1.The molecular structure of the title compound with the atom numbering scheme. Displacement ellipsoids are drawn at the 50% probability level. H atoms are presented as small spheres of arbitrary radius. Fig. 2. A view of the N—H···N (black dotted lines) and C—H···π (red dashed lines) interactions in the of the title compound. H atoms non-participating in hydrogen-bonding were omitted for clarity. Symmetry codes: (i) -x, -y + 1, -z + 1; (ii) -x + 0.5, y - 0.5, -z + 0.5. |
C10H14ClN5 | F(000) = 504 |
Mr = 239.71 | Dx = 1.372 Mg m−3 |
Monoclinic, P21/n | Melting point: 392 K |
Hall symbol: -P 2yn | Mo Kα radiation, λ = 0.71073 Å |
a = 8.1385 (2) Å | Cell parameters from 9070 reflections |
b = 9.6245 (2) Å | θ = 2.9–27.2° |
c = 14.8388 (3) Å | µ = 0.31 mm−1 |
β = 92.997 (2)° | T = 120 K |
V = 1160.72 (4) Å3 | Block, colourless |
Z = 4 | 0.40 × 0.40 × 0.20 mm |
Oxford Diffraction Xcalibur diffractometer with a Sapphire2 (large Be window) detector | 2041 independent reflections |
Radiation source: Enhance (Mo) X-ray Source | 1793 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.015 |
Detector resolution: 8.4353 pixels mm-1 | θmax = 25.0°, θmin = 2.9° |
ω scan | h = −9→9 |
Absorption correction: multi-scan CrysAlis RED (Oxford Diffraction, 2009) | k = −10→11 |
Tmin = 0.973, Tmax = 1.000 | l = −17→17 |
13543 measured reflections |
Refinement on F2 | 0 restraints |
Least-squares matrix: full | H atoms treated by a mixture of independent and constrained refinement |
R[F2 > 2σ(F2)] = 0.025 | w = 1/[σ2(Fo2) + (0.0372P)2 + 0.3781P] where P = (Fo2 + 2Fc2)/3 |
wR(F2) = 0.069 | (Δ/σ)max = 0.001 |
S = 1.07 | Δρmax = 0.21 e Å−3 |
2041 reflections | Δρmin = −0.22 e Å−3 |
152 parameters |
C10H14ClN5 | V = 1160.72 (4) Å3 |
Mr = 239.71 | Z = 4 |
Monoclinic, P21/n | Mo Kα radiation |
a = 8.1385 (2) Å | µ = 0.31 mm−1 |
b = 9.6245 (2) Å | T = 120 K |
c = 14.8388 (3) Å | 0.40 × 0.40 × 0.20 mm |
β = 92.997 (2)° |
Oxford Diffraction Xcalibur diffractometer with a Sapphire2 (large Be window) detector | 2041 independent reflections |
Absorption correction: multi-scan CrysAlis RED (Oxford Diffraction, 2009) | 1793 reflections with I > 2σ(I) |
Tmin = 0.973, Tmax = 1.000 | Rint = 0.015 |
13543 measured reflections |
R[F2 > 2σ(F2)] = 0.025 | 0 restraints |
wR(F2) = 0.069 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.07 | Δρmax = 0.21 e Å−3 |
2041 reflections | Δρmin = −0.22 e Å−3 |
152 parameters |
Experimental. Spectral properties of title compound:1H NMR (CDCl3): 1.30 (t, J = 7.3 Hz, 3H, NHCH2CH3), 1.57 (d, J = 6.6 Hz, 6H, CH(CH3)2), 3.72 (m, 2H, NHCH2CH3), 4.80 (septet, J = 6.9 Hz, 1H, CH(CH3)2), 5.84 (bs, 1H, NHCH2CH3), 7.76 (s, 1H, NC8HN) p.p.m.. 13 C NMR (CDCl3): 15.1(CH3), 23.0(CH3), 36.0(CH2), 47.1(CH), 119.0(C), 137.6(CH), 154.5(C), 155.5(C) p.p.m.. IR (KBr): 3103(m), 2974(m), 2933(w), 1726(w), 1605(s), 1560(m), 1481(w), 1454(w), 1435(w), 1404(m), 1362(m), 1309(s), 1227(s), 1188(w), 130(w), 1034(s), 941(m), 874(m), 785(m), 657(m), 609(w) cm-1. GC—EI—MS (200 °C, 70 eV): 241(M+(37Cl), 30), 240 (13), 239(M+(35Cl), 95), 226 (20), 225 (7), 224 (62), 213 (10), 211 (32), 199 (9), 198 (18), 197 (27), 196 (45), 184 (32), 183 (9), 182 (100), 171 (17), 169 (54), 161 (27), 160 (17), 156 (6), 155 (10), 154 (19), 153 (8), 146 (20), 134 (43), 133 (22), 120 (6), 119 (47), 118 (5), 108 (9), 107 (12), 106 (7), 93 (8), 92 (21), 80 (7), 68 (5), 67 (9), 66 (11), 65 (6), 55 (6), 54 (12), 53 (9), 44 (74), 43 (34), 42 (11), 41 (34), 40 (6) m/z(%). Elemental analysis calc for C10H14ClN4 (239.70) C 50.11, H 5.89, N 29.22; found C 50.16, H 5.92, N 29.02. |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
Cl1 | 0.71286 (4) | 0.25662 (4) | 0.37828 (2) | 0.02326 (12) | |
N1 | 0.46503 (13) | 0.39081 (11) | 0.30528 (7) | 0.0176 (2) | |
N2 | 0.45822 (13) | 0.33371 (11) | 0.46370 (7) | 0.0172 (2) | |
N3 | 0.24124 (14) | 0.38987 (12) | 0.55160 (7) | 0.0195 (3) | |
H3 | 0.147 (2) | 0.4230 (17) | 0.5565 (11) | 0.027 (4)* | |
N4 | 0.08494 (13) | 0.52739 (11) | 0.38017 (7) | 0.0194 (3) | |
N5 | 0.21933 (13) | 0.51796 (11) | 0.25145 (7) | 0.0180 (2) | |
C1 | 0.52134 (15) | 0.33857 (13) | 0.38306 (8) | 0.0169 (3) | |
C2 | 0.31722 (15) | 0.45181 (13) | 0.31630 (8) | 0.0164 (3) | |
C3 | 0.23370 (15) | 0.45883 (13) | 0.39493 (9) | 0.0164 (3) | |
C4 | 0.30943 (15) | 0.39438 (13) | 0.47204 (8) | 0.0166 (3) | |
C5 | 0.31812 (16) | 0.31996 (15) | 0.63006 (8) | 0.0211 (3) | |
H5A | 0.2794 | 0.3635 | 0.6855 | 0.025* | |
H5B | 0.4388 | 0.3329 | 0.6301 | 0.025* | |
C6 | 0.27990 (19) | 0.16560 (16) | 0.63171 (10) | 0.0312 (4) | |
H6A | 0.3327 | 0.1238 | 0.6861 | 0.047* | |
H6B | 0.3218 | 0.1212 | 0.5781 | 0.047* | |
H6C | 0.1606 | 0.1521 | 0.6321 | 0.047* | |
C7 | 0.08323 (16) | 0.56029 (14) | 0.29428 (9) | 0.0199 (3) | |
H7 | −0.0051 | 0.6094 | 0.2644 | 0.024* | |
C8 | 0.25198 (17) | 0.53989 (14) | 0.15553 (9) | 0.0210 (3) | |
H8 | 0.1594 | 0.5962 | 0.1277 | 0.025* | |
C9 | 0.40995 (17) | 0.62252 (15) | 0.14745 (9) | 0.0250 (3) | |
H9A | 0.4035 | 0.7089 | 0.1820 | 0.038* | |
H9B | 0.4244 | 0.6445 | 0.0839 | 0.038* | |
H9C | 0.5037 | 0.5674 | 0.1712 | 0.038* | |
C10 | 0.25535 (19) | 0.40217 (16) | 0.10584 (10) | 0.0285 (3) | |
H10A | 0.1506 | 0.3537 | 0.1119 | 0.043* | |
H10B | 0.3455 | 0.3448 | 0.1317 | 0.043* | |
H10C | 0.2722 | 0.4190 | 0.0418 | 0.043* |
U11 | U22 | U33 | U12 | U13 | U23 | |
Cl1 | 0.01873 (19) | 0.0305 (2) | 0.02086 (19) | 0.00947 (13) | 0.00355 (13) | 0.00232 (13) |
N1 | 0.0166 (6) | 0.0174 (6) | 0.0189 (6) | 0.0010 (4) | 0.0019 (4) | −0.0002 (4) |
N2 | 0.0164 (5) | 0.0172 (6) | 0.0181 (5) | 0.0006 (4) | 0.0015 (4) | −0.0013 (4) |
N3 | 0.0169 (6) | 0.0237 (6) | 0.0181 (6) | 0.0048 (5) | 0.0037 (4) | 0.0010 (4) |
N4 | 0.0170 (6) | 0.0193 (6) | 0.0220 (6) | 0.0021 (4) | 0.0018 (4) | 0.0002 (5) |
N5 | 0.0164 (6) | 0.0199 (6) | 0.0179 (5) | 0.0021 (4) | 0.0012 (4) | 0.0019 (5) |
C1 | 0.0148 (6) | 0.0156 (7) | 0.0203 (6) | 0.0007 (5) | 0.0019 (5) | −0.0015 (5) |
C2 | 0.0158 (6) | 0.0141 (7) | 0.0191 (6) | −0.0012 (5) | −0.0004 (5) | −0.0003 (5) |
C3 | 0.0151 (6) | 0.0143 (7) | 0.0200 (6) | −0.0007 (5) | 0.0014 (5) | −0.0015 (5) |
C4 | 0.0169 (6) | 0.0136 (6) | 0.0192 (6) | −0.0023 (5) | 0.0010 (5) | −0.0027 (5) |
C5 | 0.0202 (7) | 0.0265 (8) | 0.0166 (6) | 0.0029 (6) | 0.0020 (5) | 0.0003 (5) |
C6 | 0.0311 (8) | 0.0295 (9) | 0.0329 (8) | −0.0026 (6) | 0.0016 (6) | 0.0085 (6) |
C7 | 0.0159 (6) | 0.0200 (7) | 0.0238 (7) | 0.0025 (5) | 0.0014 (5) | 0.0015 (6) |
C8 | 0.0202 (7) | 0.0261 (8) | 0.0169 (6) | 0.0038 (5) | 0.0008 (5) | 0.0044 (5) |
C9 | 0.0255 (7) | 0.0241 (8) | 0.0258 (7) | 0.0015 (6) | 0.0046 (6) | 0.0065 (6) |
C10 | 0.0300 (8) | 0.0333 (9) | 0.0220 (7) | −0.0012 (6) | −0.0001 (6) | −0.0046 (6) |
Cl1—C1 | 1.7516 (13) | C5—H5A | 0.9900 |
N1—C1 | 1.3189 (16) | C5—H5B | 0.9900 |
N1—C2 | 1.3561 (16) | C6—H6A | 0.9800 |
N2—C1 | 1.3274 (16) | C6—H6B | 0.9800 |
N2—C4 | 1.3558 (16) | C6—H6C | 0.9800 |
N3—C4 | 1.3312 (17) | C7—H7 | 0.9500 |
N3—C5 | 1.4572 (17) | C8—C10 | 1.518 (2) |
N3—H3 | 0.837 (17) | C8—C9 | 1.5217 (19) |
N4—C7 | 1.3126 (17) | C8—H8 | 1.0000 |
N4—C3 | 1.3861 (17) | C9—H9A | 0.9800 |
N5—C7 | 1.3677 (17) | C9—H9B | 0.9800 |
N5—C2 | 1.3733 (16) | C9—H9C | 0.9800 |
N5—C8 | 1.4766 (16) | C10—H10A | 0.9800 |
C2—C3 | 1.3824 (18) | C10—H10B | 0.9800 |
C3—C4 | 1.4143 (18) | C10—H10C | 0.9800 |
C5—C6 | 1.518 (2) | ||
C1—N1—C2 | 109.23 (11) | C5—C6—H6A | 109.5 |
C1—N2—C4 | 117.17 (11) | C5—C6—H6B | 109.5 |
C4—N3—C5 | 122.83 (12) | H6A—C6—H6B | 109.5 |
C4—N3—H3 | 119.4 (11) | C5—C6—H6C | 109.5 |
C5—N3—H3 | 117.6 (11) | H6A—C6—H6C | 109.5 |
C7—N4—C3 | 103.48 (10) | H6B—C6—H6C | 109.5 |
C7—N5—C2 | 105.47 (10) | N4—C7—N5 | 114.31 (12) |
C7—N5—C8 | 126.60 (11) | N4—C7—H7 | 122.8 |
C2—N5—C8 | 127.93 (11) | N5—C7—H7 | 122.8 |
N1—C1—N2 | 132.00 (12) | N5—C8—C10 | 110.62 (11) |
N1—C1—Cl1 | 113.92 (9) | N5—C8—C9 | 110.24 (11) |
N2—C1—Cl1 | 114.06 (9) | C10—C8—C9 | 112.42 (12) |
N1—C2—N5 | 127.02 (11) | N5—C8—H8 | 107.8 |
N1—C2—C3 | 126.96 (12) | C10—C8—H8 | 107.8 |
N5—C2—C3 | 106.02 (11) | C9—C8—H8 | 107.8 |
C2—C3—N4 | 110.72 (11) | C8—C9—H9A | 109.5 |
C2—C3—C4 | 116.66 (12) | C8—C9—H9B | 109.5 |
N4—C3—C4 | 132.59 (12) | H9A—C9—H9B | 109.5 |
N3—C4—N2 | 118.86 (12) | C8—C9—H9C | 109.5 |
N3—C4—C3 | 123.20 (12) | H9A—C9—H9C | 109.5 |
N2—C4—C3 | 117.94 (11) | H9B—C9—H9C | 109.5 |
N3—C5—C6 | 112.64 (11) | C8—C10—H10A | 109.5 |
N3—C5—H5A | 109.1 | C8—C10—H10B | 109.5 |
C6—C5—H5A | 109.1 | H10A—C10—H10B | 109.5 |
N3—C5—H5B | 109.1 | C8—C10—H10C | 109.5 |
C6—C5—H5B | 109.1 | H10A—C10—H10C | 109.5 |
H5A—C5—H5B | 107.8 | H10B—C10—H10C | 109.5 |
C2—N1—C1—N2 | 2.0 (2) | C5—N3—C4—N2 | −1.24 (19) |
C2—N1—C1—Cl1 | −179.87 (9) | C5—N3—C4—C3 | 178.29 (12) |
C4—N2—C1—N1 | −1.4 (2) | C1—N2—C4—N3 | 179.07 (11) |
C4—N2—C1—Cl1 | −179.56 (9) | C1—N2—C4—C3 | −0.48 (17) |
C1—N1—C2—N5 | 179.90 (12) | C2—C3—C4—N3 | −178.20 (12) |
C1—N1—C2—C3 | −0.80 (18) | N4—C3—C4—N3 | −0.3 (2) |
C7—N5—C2—N1 | 179.21 (12) | C2—C3—C4—N2 | 1.33 (17) |
C8—N5—C2—N1 | −0.8 (2) | N4—C3—C4—N2 | 179.24 (13) |
C7—N5—C2—C3 | −0.21 (14) | C4—N3—C5—C6 | −85.04 (16) |
C8—N5—C2—C3 | 179.74 (12) | C3—N4—C7—N5 | 0.27 (15) |
N1—C2—C3—N4 | −179.04 (12) | C2—N5—C7—N4 | −0.05 (15) |
N5—C2—C3—N4 | 0.38 (14) | C8—N5—C7—N4 | −179.99 (12) |
N1—C2—C3—C4 | −0.68 (19) | C7—N5—C8—C10 | −114.50 (14) |
N5—C2—C3—C4 | 178.74 (11) | C2—N5—C8—C10 | 65.56 (16) |
C7—N4—C3—C2 | −0.40 (14) | C7—N5—C8—C9 | 120.53 (14) |
C7—N4—C3—C4 | −178.41 (14) | C2—N5—C8—C9 | −59.40 (17) |
Cg1 is the center of gravity of the pyridine ring (C1, N1, C2, C3, C4, N2). |
D—H···A | D—H | H···A | D···A | D—H···A |
N3—H3···N4i | 0.837 (16) | 2.205 (17) | 2.9979 (16) | 158.2 (15) |
C8—H8···Cg1ii | 1.00 (1) | 2.90 (1) | 3.6403 (13) | 131 (1) |
Symmetry codes: (i) −x, −y+1, −z+1; (ii) −x+1/2, y+1/2, −z+1/2. |
Experimental details
Crystal data | |
Chemical formula | C10H14ClN5 |
Mr | 239.71 |
Crystal system, space group | Monoclinic, P21/n |
Temperature (K) | 120 |
a, b, c (Å) | 8.1385 (2), 9.6245 (2), 14.8388 (3) |
β (°) | 92.997 (2) |
V (Å3) | 1160.72 (4) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.31 |
Crystal size (mm) | 0.40 × 0.40 × 0.20 |
Data collection | |
Diffractometer | Oxford Diffraction Xcalibur diffractometer with a Sapphire2 (large Be window) detector |
Absorption correction | Multi-scan CrysAlis RED (Oxford Diffraction, 2009) |
Tmin, Tmax | 0.973, 1.000 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 13543, 2041, 1793 |
Rint | 0.015 |
(sin θ/λ)max (Å−1) | 0.594 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.025, 0.069, 1.07 |
No. of reflections | 2041 |
No. of parameters | 152 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.21, −0.22 |
Computer programs: CrysAlis CCD (Oxford Diffraction, 2009), CrysAlis RED (Oxford Diffraction, 2009), SHELXS97 (Sheldrick, 2008), SHELXL97 (Sheldrick, 2008), ORTEP-3 (Farrugia, 1997) and Mercury (Macrae et al., 2008).
Cg1 is the center of gravity of the pyridine ring (C1, N1, C2, C3, C4, N2). |
D—H···A | D—H | H···A | D···A | D—H···A |
N3—H3···N4i | 0.837 (16) | 2.205 (17) | 2.9979 (16) | 158.2 (15) |
C8—H8···Cg1ii | 0.9997 (13) | 2.90380 (10) | 3.6403 (13) | 131.15 (8) |
Symmetry codes: (i) −x, −y+1, −z+1; (ii) −x+1/2, y+1/2, −z+1/2. |
Acknowledgements
The financial support of this work by the Tomas Bata Foundation and by the Internal Founding Agency of Tomas Bata University in Zlin (project No. IGA/FT/2012/016) is gratefully acknowledged.
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The wide range of biological activities of di-, tri-, or tetrasubstituted purines is closely associated with essentially unlimited number of substituents that can be combined in the C2, C6, C8 and N9 positions of the purine ring (Legraverend & Grierson, 2006). The title molecule has been prepared as a part of our ongoing study of novel 2,6,9-trisubstituted purine series (Rouchal et al., 2009a,b, 2010). To the best of our knowledge, the title compound has not been described in the literature so far.
In the title molecule (Fig. 1), the purine unit is essentially planar, with a r.m.s. deviation of 0.0063 (11) Å from the least-squares plane defined by the nine constituent atoms. Although all pyrimidine atoms lie essentially in plane, the ring is markedly deformed from regular hexagon geometry with N1–C2–N3 angle of 132.0 (11)°. In the crystal structure (Fig. 2), molecules are connected by weak intermolecular N—H···N and C—H···π interactions (Table 1).