Crystal structure of (1S*,2R*)-7-benz­yloxy-2-methyl-3-tosyl-2,3,4,5-tetra­hydro-1H-3-benz­azepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

Tewes, B.; Frehland, B.; Fröhlich, R.; Wünsch, B.

doi:10.1107/S2056989016005855

Acta Crystallographica Section E
Acta Crystallographica
Section E CRYSTALLOGRAPHIC COMMUNICATIONS

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Figure 1
Synthesis of GluN2B antagonists including the lead compound ifenprodil and the target compound (S,R)-4. Reagents and reaction conditions: (a) NaBH₄, CH₃OH, (S,R)-2 50%, (R,R)-3 23%.

CRYSTALLOGRAPHIC
COMMUNICATIONS

ISSN: 2056-9890

Volume 72| Part 5| May 2016| Pages 683-686

doi:10.1107/S2056989016005855

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