Crystal structure and Hirshfeld surface analysis of 4-allyl-2-meth­oxy-6-nitro­phenol

El Ghallab, Y.; Derfoufi, S.; Ketatni, E.M.; Saadi, M.; El Ammari, L.

doi:10.1107/S2056989020002601

research communications

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ISSN: 2056-9890

Volume 76| Part 3| March 2020| Pages 461-465

https://doi.org/10.1107/S2056989020002601

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Crystal structure and Hirshfeld surface analysis of 4-allyl-2-methoxy-6-nitrophenol

Yassine El Ghallab,^a ^* Sanae Derfoufi,^a El Mostafa Ketatni,^b Mohamed Saadi ^c and Lahcen El Ammari ^c

^aLaboratory of Drugs Sciences, Biomedical Research and Biotechnology, Faculty of Medicine and Pharmacy, Hassan II University, BP 9154, Casablanca 20250, Morocco, ^bLaboratory of Organic and Analytical Chemistry, University Sultan Moulay, Slimane, Faculty of Science and Technology, PO Box 523, Beni-Mellal, Morocco, and ^cLaboratoire de Chimie Appliquée des Matériaux, Centre des Sciences des Matériaux, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Batouta, BP 1014, Rabat, Morocco
^*Correspondence e-mail: y_ghallab@yahoo.com

Edited by C. Rizzoli, Universita degli Studi di Parma, Italy (Received 29 January 2020; accepted 25 February 2020; online 28 February 2020)

The asymmetric unit of the title compound, C₁₀H₁₁NO₄, which was synthesized via nitration reaction of eugenol (4-allyl-2-methoxyphenol) with a mixture of nitric acid and sulfuric acid, consists of three independent molecules of similar geometry. Each molecule displays an intramolecular hydrogen bond involving the hydroxide and the nitro group forming an S(6) motif. The crystal cohesion is ensured by intermolecular C—H⋯O hydrogen bonds in addition to π–π stacking interactions between the aromatic rings [centroid–centroid distances = 3.6583 (17)–4.0624 (16) Å]. The Hirshfeld surface analysis and the two-dimensional fingerprint plots show that H⋯H (39.6%), O⋯H/H⋯O (37.7%), C⋯H/H⋯C (12.5%) and C⋯C (4%) are the most important contributors towards the crystal packing.

Keywords: crystal structure; nitroeugenol; hydrogen bonds; Hirshfeld surface analysis; IR; NMR.

CCDC reference: 1986157

1. Chemical context

Eugenol, the main constituent of clove essential oil, has many interesting biological properties and participates in the synthesis of bioactive compounds (Kaufman, 2015 ). The nitroeugenol isomers were tested for their antifungal activity, growth inhibitory activity on human tumor cell lines (Carrasco et al., 2012 , 2008 ), and antioxidant activity (Hidalgo et al., 2009 ). We report here the synthesis, structure, spectrometric and spectroscopic characterization of the title compound along with an analysis of the calculated Hirshfeld surface and the two-dimensional fingerprint plots.

2. Structural commentary

The asymmetric unit of the title compound (Fig. 1) contains three independent molecules of similar geometry hereafter referred as Mol-N1 (N1/O1–O4/C1–C10), Mol-N2 (N2/O5–O8/C11–C20) and Mol-N3 (N3/O9–O12/C21–C30). The planes through the nitro groups are almost coplanar with those of the attached benzene rings, forming dihedral angles ranging from 2.1 (3)° in Mol-N3 to 6.38 (13)° in Mol-N2. The mean planes though the allyl group C1/C2/C3 (molecule Mol-N1) and the disordered allyl groups C11A/C11B/C12A/C12B/C13 (molecule Mol-N2) and C21A/C21B/C22A/C22B/C23 (molecule Mol-N3) are oriented with dihedral angles of 67.5 (3), 80.8 (3) and 86.1 (4)°, respectively, to the attached benzene rings. The benzene rings of molecules Mol-N2 and Mol-N3 are approximately parallel to each other [dihedral angle 10.60 (7)°], and roughly perpendicular to that of Mol-N1 [dihedral angles of 83.65 (7) and 79.22 (6)°, respectively]. A strong intramolecular O—H⋯O hydrogen bond involving a nitro O atom and the H atom of the hydroxide group forming an S(6) motif is observed in each molecule (Table 1).

Table 1
Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O10—H10⋯O11	0.86 (3)	1.81 (3)	2.594 (2)	149 (2)
O6—H6⋯O7	0.83 (2)	1.83 (2)	2.584 (2)	152 (2)
O2—H2O⋯O3	0.91 (3)	1.78 (3)	2.587 (2)	146 (2)
C12A—H12A⋯O12	0.93	2.58	3.382 (4)	145
C12B—H12B⋯O3ⁱ	0.93	2.56	3.325 (8)	140
C9—H9⋯O7ⁱⁱ	0.93	2.59	3.394 (2)	145
Symmetry codes: (i) -x+1, -y+1, -z+1; (ii) -x+2, -y+1, -z+2.

Figure 1
The asymmetric unit of the title compound with the displacement ellipsoids drawn at the 50% probability level. H atoms are represented as small circles. Intra- and intermolecular hydrogen bonds are shown as dashed lines.

3. Supramolecular features

In the crystal, the molecules are connected by intermolecular C12A—H12A⋯O12, C12B—H12B⋯O3 and C9—H9⋯O7 hydrogen bonds (Table 1; Figs. 2 and 3). In addition, centrosymmetrically related pairs of Mol-N1 molecules are connected by π–π interactions to form dimeric units [centroid–centroid distance = 3.7213 (15) Å] (Fig. 2), whereas the Mol-N2 and Mol-N3 molecules are stacked through π–π interactions to form chains running parallel to the b axis [Cg2⋯Cg2ⁱ = 3.6583 (17) Å; Cg2⋯Cg3ⁱⁱ = 3.6613 (18) Å; Cg3⋯Cg3ⁱⁱⁱ = 4.0624 (16) Å; symmetry codes: (i) 2 − x, 1 − y, 1 − z; (ii) 1 + x, y, z; (iii) −x, −y, 1 − z].

Figure 2
Partial crystal packing of the title compound showing molecules connected by hydrogen bonds (dashed cyan lines) and π–π interactions (dashed green lines).

Figure 3
Crystal packing of the title compound viewed along the a axis showing molecules linked by hydrogen bonds (dashed cyan lines).

4. Hirshfeld surface analysis

In order to explore the nature of the intermolecular contacts and their role in the crystal packing, Hirshfeld surfaces (Spackman & Jayatilaka, 2009 ) and the associated two-dimensional fingerprint plots (McKinnon et al., 2007 ) were calculated using Crystal Explorer 17.5 (Turner et al., 2017 ). The three-dimensional molecular Hirshfeld surfaces of the three molecules Mol-N1, Mol-N2 and Mol-N3 and the overall surface were generated using a high standard surface resolution colour-mapped over the normalized contact distance. The red, white and blue regions visible on the d_norm surfaces indicate contacts with distances shorter, longer and equal to the van der Waals radii (Fig. 4a and 5a). The shape-index of the Hirshfeld surface is a tool to visualize the π–π stacking interactions (Fig. 4b and 5b). The red spots in Fig. 4a correspond to the strong C—H⋯O hydrogen-bond interactions in the crystal structure; in Mol-N1 two of them involve the O atoms of the methoxy (O1) and nitro (O3) groups as acceptors with allyl H atoms (C22B– H22B⋯O1 and C12B—H12B⋯O3), while the other is due to the interatomic interaction between the aromatic H9 donor atom and the nitro O7 oxygen atom (C9—H9⋯O7). The longer O—H⋯O hydrogen bonds and O⋯O interactions are characterized by smaller red spots close to each other on the surface, where the faint red spot indicating the O—H⋯O interactions is associated with the longest O⋯O contact of 2.96 (3) Å in Mol-N1 and Mol-N3. In Mol-N2, the red spots correspond to C—H⋯O (C9—H9⋯O7 and C12A—H12A⋯O12) and C—H⋯C (C20—H20B⋯C11A) hydrogen-bond interactions. The corresponding fingerprint plots for each of the independent molecules and for the entire asymmetric unit, showing characteristic pseudo-symmetric wings in the d_e and d_i diagonal axes, and those delineated into H⋯H, O⋯H/H⋯O, C⋯H/H⋯C and C⋯C contacts are illustrated in Fig. 6. The result of the quantitative analysis of all types of intermolecular contacts present in the title compound is summarized in Fig. 7. The most important interaction is H⋯H, contributing 45.4% to the overall crystal packing (Fig. 6b), which is reflected in the widely scattered points of high density due to the large hydrogen-atom content of the molecule. The contribution from the O⋯H/H⋯O contacts (31.7%), corresponding to C—H⋯O and O—H⋯O interactions, is represented by a pair of sharp spikes characteristic of a strong hydrogen-bond interaction with d_e + d_i ≃ 2.5Å (Fig. 6c). In the absence of weak C—H⋯π interactions in the crystal, the pair of characteristic wings in the fingerprint plot delineated into H⋯C/C⋯H contacts (7.7% contribution) have a symmetrical distribution of points (Fig. 6d), with the tips at d_e + d_i ≃ 2.65 Å. The distribution of points in the d_e = d_i ≃ 1.6 Å range in the fingerprint plot delineated into C⋯C contacts (Fig. 6e) indicates the existence of weak π–π stacking interactions between the phenyl rings, which are indicated by adjacent red and blue triangles in the shape-index map (Fig. 4b and Fig. 5c). The small contribution of the other weak intermolecular O⋯O, N⋯H/H⋯N, C⋯O/O⋯C, C⋯N/N⋯C and N⋯O/O⋯N contacts has a negligible effect on the packing.

Figure 4
Hirshfeld surface of the title compound (symmetry-independent molecules Mol-N1, Mol-N2 and Mol-N3), with (a) d_norm with the interaction of neighbouring molecules and (b) shape-index.

Figure 5
Views of the Hirshfeld surface for a reference molecule of the title compound mapped over (a) d_norm, (b) shape-index and (c) the shape-index property highlighting the π–π interactions as black dashed lines.

Figure 6
Fingerprint plots representative of specific interatomic contacts in the title compound (symmetry-independent molecules Mol-N1, Mol-N2, Mol-N3 and overall), delineated into H⋯H, O⋯H/H⋯O, C⋯H/H⋯C and C⋯C interactions.

Figure 7
Percentage contribution of various intermolecular interactions in the title compound obtained from decomposed fingerprint plots.

5. Database survey

A search of the Cambridge Structural Database (CSD, Version 5.40, May 2019; Groom et al., 2016 ) of eugenol derivatives revealed two compounds with very similar structures but with a different position of the nitro group or with the hydroxide group substituted by an acetate group, viz. 4-allyl-2-methoxy-5-nitrophenyl acetate (refcode: TEJREG; Carrasco-Altamirano et al., 2006 ) and 4-hydroxy-3-methoxy-5-nitroacetophenone (5-nitroapocynin) (MUCDOE; Babu et al., 2009 ). A third related compound, 4-hydroxy-3-methoxy-5-nitrobenzaldehyde, has recently been reported (Vusak et al., 2020 ). All of these compounds exhibit intramolecular hydrogen bonds involving the nitro O atoms with the H atoms of the hydroxide group, and other intermolecular hydrogen bonds, in addition to π–π interactions, which assure the crystal cohesion.

6. Synthesis and crystallization

In a 250 mL flat-bottom flask containing a stirred solution of eugenol (2.12 g, 12.9 mmol) and dichloromethane (60 mL), a mixture of concentrated sulfuric acid (0.78 mL) and concentrated nitric acid (0.80 mL) was added dropwise for 30 min at 273 K. The complete disappearance of the starting product was confirmed by means of thin layer chromatography using n-hexane/AcOEt (9:1 v/v) as eluent. The reaction mixture was diluted with dichloromethane, washed with brine (3 × 10 mL), dried over anhydrous Na₂SO₄ and concentrated under vacuum. The crude product was subjected to chromatography on a silica-gel column with n-hexane/AcOEt (9:1 v/v) as eluent to afford the title compound as a reddish-orange liquid. Reddish-orange crystals formed spontaneously with a yield of 56%. Good quality crystals suitable for single crystal X-ray diffraction analysis were obtained by slow evaporation of an n-hexane:AcOEt solution, m.p. = 317–319 K.

IR (cm⁻¹): 3235, 3080, 3016, 2971, 2910, 1638, 1537, 1392, 1331, 1262, 1128, 1059, 909, 763. The FT–IR spectrum (Fig. 8) illustrates several bands characteristic of 4-allyl-2-methoxy-6-nitrophenol. The absorption band at 3235 cm⁻¹ was assigned to the O—H stretching vibration. The bands located at 3080 and 3016 cm⁻¹ correspond to the C=CH bond of the aromatic ring and CH=CH₂ bond of the allyl group, respectively. The remarkably strong band at 1537 cm⁻¹ was attributed to the stretching vibration of the nitro group. Other C=C stretching vibrations are at 2971, 2910 and 1638 cm⁻¹. The FT–IR spectrum peaks are in agreement with the reported data for similar compounds (Carrasco et al., 2008; Egorov et al., 2014 ; Heredia et al., 2016 ).

Figure 8
The FT–IR spectrum of the title compound.

¹H NMR (CDCl₃, 300 MHz) δ 10.7 (s, 1H, OH conjugated), 7.53 (s, 1H, Ar-H), 6.99 (s, 1H, Ar-H), 6.01–5.88 (m, 1H), 5.19–5.13 (m, 2H), 3.96 (s, 3H), 3.39–3.37 (d, 2H). ¹³C NMR (CDCl₃, 75.5 MHz) δ 149.87, 144.90, 135.95, 133.66, 131.24, 118.63, 117.16, 115.11, 114.29, 56.72, 39.41. FTMS–ESI, m/z: 208.04616 (100%) [C₁₀H₁₁NO₄].

7. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 2. The C-bound H atoms were located in a difference-Fourier map and refined as riding with C—H = 0.93–0.97 Å, and U_iso(H) = 1.2 U_eq(C) or 1.5U_eq(C) for methyl H atoms. A rotating model was used for the methyl groups. The hydroxyl H atoms were located in a difference-Fourier map and refined freely. The two allyl groups of Mol-N2 and Mol-N3 are disordered over two sets of sites with refined occupancy ratios of 0.648 (8):0.352 (8) and 0.668 (9):0.332 (9) respectively. One outlier (100) was omitted in the cycles of refinement.

Table 2
Experimental details

Crystal data
Chemical formula	C₁₀H₁₁NO₄
M_r	209.20
Crystal system, space group	Triclinic, P $[\overline{1}]$
Temperature (K)	296
a, b, c (Å)	8.706 (3), 13.753 (5), 14.683 (5)
α, β, γ (°)	116.142 (11), 93.871 (12), 96.985 (12)
V (Å³)	1552.0 (9)
Z	6
Radiation type	Mo Kα
μ (mm⁻¹)	0.11
Crystal size (mm)	0.31 × 0.28 × 0.26

Data collection
Diffractometer	Bruker D8 VENTURE Super DUO
Absorption correction	Multi-scan (SADABS; Krause et al., 2015 )
T_min, T_max	0.707, 0.746
No. of measured, independent and observed [I > 2σ(I)] reflections	54955, 6334, 4687
R_int	0.037
(sin θ/λ)_max (Å⁻¹)	0.625

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.047, 0.134, 1.02
No. of reflections	6334
No. of parameters	460
H-atom treatment	H atoms treated by a mixture of independent and constrained refinement
Δρ_max, Δρ_min (e Å⁻³)	0.41, −0.20
Computer programs: APEX3 and SAINT (Bruker, 2016 ), SHELXT2014/5 (Sheldrick, 2015a ), SHELXL2016/6 (Sheldrick, 2015b ), ORTEP-3 for Windows (Farrugia, 2012 ); Mercury (Macrae et al., 2020 ) and publCIF (Westrip, 2010 ).

Supporting information

CCDC reference: 1986157

Crystal structure: contains datablock I. DOI: https://doi.org/10.1107/S2056989020002601/rz5270sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989020002601/rz5270Isup2.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2056989020002601/rz5270Isup3.cml

checkCIF report

Computing details top

Data collection: APEX3 (Bruker, 2016); cell refinement: SAINT (Bruker, 2016); data reduction: SAINT (Bruker, 2016); program(s) used to solve structure: SHELXT2014/5 (Sheldrick, 2015a); program(s) used to refine structure: SHELXL2016/6 (Sheldrick, 2015b); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); Mercury (Macrae et al., 2020); software used to prepare material for publication: publCIF (Westrip, 2010).

4-Allyl-2-methoxy-6-nitrophenol top

Crystal data top

C₁₀H₁₁NO₄	Z = 6
M_r = 209.20	F(000) = 660
Triclinic, P1	D_x = 1.343 Mg m⁻³
a = 8.706 (3) Å	Mo Kα radiation, λ = 0.71073 Å
b = 13.753 (5) Å	Cell parameters from 6334 reflections
c = 14.683 (5) Å	θ = 2.7–26.4°
α = 116.142 (11)°	µ = 0.11 mm⁻¹
β = 93.871 (12)°	T = 296 K
γ = 96.985 (12)°	Block, orange
V = 1552.0 (9) Å³	0.31 × 0.28 × 0.26 mm

Data collection top

Bruker D8 VENTURE Super DUO diffractometer	6334 independent reflections
Radiation source: INCOATEC IµS micro-focus source	4687 reflections with I > 2σ(I)
HELIOS mirror optics monochromator	R_int = 0.037
Detector resolution: 10.4167 pixels mm^-1	θ_max = 26.4°, θ_min = 2.7°
φ and ω scans	h = −10→10
Absorption correction: multi-scan (SADABS; Krause et al., 2015)	k = −17→17
T_min = 0.707, T_max = 0.746	l = −18→18
54955 measured reflections

Refinement top

Refinement on F²	Hydrogen site location: mixed
Least-squares matrix: full	H atoms treated by a mixture of independent and constrained refinement
R[F² > 2σ(F²)] = 0.047	w = 1/[σ²(F_o²) + (0.0592P)² + 0.4096P] where P = (F_o² + 2F_c²)/3
wR(F²) = 0.134	(Δ/σ)_max < 0.001
S = 1.02	Δρ_max = 0.41 e Å⁻³
6334 reflections	Δρ_min = −0.20 e Å⁻³
460 parameters	Extinction correction: SHELXL-2018/3 (Sheldrick, 2015b), Fc^*=kFc[1+0.001xFc²λ³/sin(2θ)]^-1/4
0 restraints	Extinction coefficient: 0.021 (2)

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq	Occ. (<1)
C1	0.7703 (5)	0.1282 (3)	0.9575 (3)	0.1442 (14)
H1A	0.669741	0.087821	0.935152	0.173*
H1B	0.856141	0.092334	0.943266	0.173*
C2	0.7907 (4)	0.2334 (3)	1.0082 (2)	0.1086 (9)
H2	0.893725	0.269409	1.028622	0.130*
C3	0.6708 (3)	0.30301 (19)	1.03745 (18)	0.0862 (7)
H3A	0.681015	0.341956	1.111572	0.103*
H3B	0.568772	0.256699	1.013201	0.103*
C4	0.6796 (2)	0.38578 (15)	0.99543 (14)	0.0619 (5)
C5	0.5910 (2)	0.36410 (16)	0.90633 (14)	0.0628 (5)
H5	0.523012	0.297687	0.870481	0.075*
C6	0.60267 (19)	0.44162 (15)	0.86912 (13)	0.0564 (4)
C7	0.7021 (2)	0.54237 (14)	0.92020 (13)	0.0533 (4)
C8	0.79192 (19)	0.56398 (14)	1.01284 (12)	0.0516 (4)
C9	0.7813 (2)	0.48670 (15)	1.04822 (13)	0.0576 (4)
H9	0.842850	0.501427	1.108578	0.069*
C10	0.9739 (3)	0.69329 (18)	1.15663 (15)	0.0763 (6)
H10A	0.904755	0.692601	1.204647	0.115*
H10B	1.034076	0.765533	1.181861	0.115*
H10C	1.042918	0.641401	1.148116	0.115*
N1	0.50602 (19)	0.41416 (17)	0.77400 (13)	0.0741 (5)
O1	0.88445 (16)	0.66397 (10)	1.06010 (10)	0.0687 (4)
O2	0.71821 (19)	0.62197 (12)	0.89023 (11)	0.0745 (4)
O3	0.5206 (2)	0.47908 (17)	0.73564 (13)	0.1008 (6)
O4	0.41380 (18)	0.32741 (15)	0.73302 (13)	0.0988 (6)
C11A	0.4789 (14)	0.2126 (11)	0.2212 (9)	0.107 (4)	0.648 (8)
H11A	0.504547	0.263438	0.196542	0.128*	0.648 (8)
H11B	0.429013	0.141711	0.176573	0.128*	0.648 (8)
C12A	0.5127 (4)	0.2406 (3)	0.3175 (3)	0.0775 (16)	0.648 (8)
H12A	0.484720	0.186924	0.338427	0.093*	0.648 (8)
C11B	0.472 (2)	0.1982 (15)	0.2141 (18)	0.094 (7)	0.352 (8)
H11C	0.441218	0.141392	0.230507	0.113*	0.352 (8)
H11D	0.453749	0.186675	0.146615	0.113*	0.352 (8)
C12B	0.5447 (7)	0.3007 (8)	0.2904 (7)	0.075 (3)	0.352 (8)
H12B	0.570414	0.351468	0.265767	0.090*	0.352 (8)
C13	0.5863 (3)	0.3424 (3)	0.3925 (2)	0.1000 (8)
H13A	0.527879	0.363796	0.450327	0.120*	0.648 (8)
H13B	0.581070	0.395340	0.365880	0.120*	0.648 (8)
H13C	0.522486	0.297742	0.416294	0.120*	0.352 (8)
H13D	0.559627	0.415525	0.424614	0.120*	0.352 (8)
C14	0.7560 (2)	0.35083 (16)	0.43148 (15)	0.0619 (5)
C15	0.8104 (2)	0.39916 (15)	0.53351 (15)	0.0610 (5)
H15	0.742814	0.427603	0.581481	0.073*
C16	0.9676 (2)	0.40594 (13)	0.56597 (13)	0.0532 (4)
C17	1.07440 (19)	0.36536 (13)	0.49776 (13)	0.0493 (4)
C18	1.01636 (19)	0.31557 (14)	0.39249 (12)	0.0507 (4)
C19	0.8614 (2)	0.30891 (15)	0.36115 (14)	0.0568 (4)
H19	0.825339	0.275728	0.291428	0.068*
C20	1.0751 (3)	0.2270 (2)	0.22242 (15)	0.0808 (6)
H20A	0.995975	0.163994	0.203937	0.121*
H20B	1.162250	0.204457	0.186106	0.121*
H20C	1.033249	0.278869	0.204844	0.121*
N2	1.0193 (2)	0.45748 (14)	0.67507 (12)	0.0697 (4)
O5	1.12547 (14)	0.27684 (12)	0.32966 (9)	0.0664 (4)
O6	1.22701 (14)	0.36805 (12)	0.52235 (11)	0.0641 (4)
O7	1.1606 (2)	0.47349 (13)	0.70603 (11)	0.0850 (4)
O8	0.9228 (2)	0.48412 (17)	0.73412 (12)	0.1068 (6)
C21A	−0.2510 (12)	−0.0879 (7)	0.0621 (5)	0.121 (4)	0.668 (9)
H21A	−0.246926	−0.160899	0.045748	0.145*	0.668 (9)
H21B	−0.232777	−0.062093	0.014302	0.145*	0.668 (9)
C22A	−0.2799 (4)	−0.0266 (4)	0.1454 (3)	0.0764 (14)	0.668 (9)
H22A	−0.281443	0.044748	0.154888	0.092*	0.668 (9)
C21B	−0.233 (2)	−0.0934 (12)	0.0612 (16)	0.119 (8)	0.332 (9)
H21C	−0.233452	−0.028161	0.056564	0.143*	0.332 (9)
H21D	−0.206887	−0.154152	0.007319	0.143*	0.332 (9)
C22B	−0.2705 (8)	−0.0999 (9)	0.1445 (7)	0.078 (3)	0.332 (9)
H22B	−0.264145	−0.170393	0.135978	0.094*	0.332 (9)
C23	−0.3132 (3)	−0.0433 (2)	0.23518 (18)	0.0893 (7)
H23A	−0.323904	−0.121250	0.215662	0.107*	0.668 (9)
H23B	−0.412887	−0.021186	0.253318	0.107*	0.668 (9)
H23C	−0.385321	−0.093840	0.248213	0.107*	0.332 (9)
H23D	−0.371941	0.009953	0.229832	0.107*	0.332 (9)
C24	−0.1915 (2)	0.01826 (14)	0.32956 (14)	0.0575 (4)
C25	−0.0350 (2)	0.01984 (14)	0.32198 (13)	0.0547 (4)
H25	−0.001961	−0.015992	0.258299	0.066*
C26	0.07431 (18)	0.07529 (13)	0.40997 (13)	0.0483 (4)
C27	0.03114 (18)	0.13021 (13)	0.50680 (12)	0.0468 (4)
C28	−0.13073 (18)	0.12718 (13)	0.51315 (13)	0.0494 (4)
C29	−0.23785 (19)	0.07271 (14)	0.42663 (13)	0.0538 (4)
H29	−0.343672	0.071824	0.432412	0.065*
C30	−0.3235 (2)	0.1869 (2)	0.62435 (17)	0.0773 (6)
H30A	−0.364262	0.226379	0.590885	0.116*
H30B	−0.331320	0.224162	0.696188	0.116*
H30C	−0.382519	0.113848	0.595437	0.116*
N3	0.23790 (17)	0.07279 (13)	0.39773 (13)	0.0618 (4)
O9	−0.16410 (14)	0.18116 (12)	0.61035 (9)	0.0671 (4)
O10	0.12736 (15)	0.18700 (11)	0.59525 (10)	0.0635 (3)
O11	0.33723 (15)	0.11885 (14)	0.47501 (12)	0.0795 (4)
O12	0.27365 (17)	0.02443 (14)	0.31208 (13)	0.0892 (5)
H2O	0.658 (3)	0.593 (2)	0.829 (2)	0.110 (9)*
H6	1.236 (3)	0.3989 (19)	0.5856 (19)	0.083 (8)*
H10	0.218 (3)	0.180 (2)	0.5758 (19)	0.095 (8)*

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.187 (4)	0.103 (2)	0.156 (3)	0.034 (2)	0.036 (3)	0.066 (2)
C2	0.104 (2)	0.135 (3)	0.124 (2)	0.0102 (19)	0.0140 (18)	0.094 (2)
C3	0.1077 (18)	0.0779 (14)	0.0734 (14)	−0.0027 (13)	0.0214 (13)	0.0380 (12)
C4	0.0659 (11)	0.0605 (11)	0.0546 (10)	0.0049 (9)	0.0180 (9)	0.0220 (9)
C5	0.0520 (10)	0.0601 (11)	0.0576 (11)	−0.0001 (8)	0.0113 (8)	0.0118 (9)
C6	0.0435 (9)	0.0666 (11)	0.0460 (9)	0.0157 (8)	0.0047 (7)	0.0124 (8)
C7	0.0523 (9)	0.0584 (10)	0.0486 (9)	0.0199 (8)	0.0120 (7)	0.0203 (8)
C8	0.0486 (9)	0.0534 (9)	0.0450 (9)	0.0077 (7)	0.0091 (7)	0.0151 (7)
C9	0.0595 (10)	0.0661 (11)	0.0434 (9)	0.0078 (8)	0.0075 (7)	0.0220 (8)
C10	0.0808 (14)	0.0703 (13)	0.0558 (11)	−0.0058 (10)	−0.0092 (10)	0.0160 (10)
N1	0.0526 (9)	0.0891 (13)	0.0605 (10)	0.0260 (9)	−0.0019 (8)	0.0139 (10)
O1	0.0777 (9)	0.0581 (7)	0.0579 (7)	−0.0041 (6)	−0.0057 (6)	0.0210 (6)
O2	0.0933 (11)	0.0682 (9)	0.0649 (9)	0.0219 (7)	0.0013 (8)	0.0320 (7)
O3	0.0982 (12)	0.1215 (14)	0.0802 (11)	0.0284 (10)	−0.0179 (9)	0.0452 (11)
O4	0.0648 (9)	0.1008 (12)	0.0829 (11)	0.0057 (9)	−0.0214 (8)	0.0052 (9)
C11A	0.071 (7)	0.169 (11)	0.086 (6)	0.015 (6)	0.001 (5)	0.066 (7)
C12A	0.0454 (17)	0.089 (3)	0.109 (4)	0.0035 (17)	0.0061 (18)	0.058 (3)
C11B	0.047 (8)	0.072 (6)	0.116 (13)	0.002 (5)	−0.011 (7)	0.005 (7)
C12B	0.048 (3)	0.098 (6)	0.095 (6)	0.006 (3)	−0.009 (3)	0.063 (5)
C13	0.0515 (12)	0.129 (2)	0.0964 (19)	0.0272 (13)	0.0084 (12)	0.0283 (16)
C14	0.0487 (10)	0.0655 (11)	0.0684 (12)	0.0144 (8)	0.0089 (8)	0.0262 (9)
C15	0.0617 (11)	0.0596 (10)	0.0645 (11)	0.0196 (8)	0.0200 (9)	0.0267 (9)
C16	0.0638 (11)	0.0497 (9)	0.0492 (9)	0.0134 (8)	0.0077 (8)	0.0243 (8)
C17	0.0489 (9)	0.0491 (9)	0.0547 (9)	0.0089 (7)	0.0046 (7)	0.0281 (8)
C18	0.0457 (9)	0.0558 (9)	0.0537 (10)	0.0080 (7)	0.0093 (7)	0.0274 (8)
C19	0.0479 (9)	0.0638 (11)	0.0542 (10)	0.0076 (8)	0.0029 (7)	0.0237 (8)
C20	0.0663 (13)	0.1128 (18)	0.0546 (11)	0.0144 (12)	0.0145 (9)	0.0295 (12)
N2	0.0902 (13)	0.0670 (10)	0.0547 (9)	0.0267 (9)	0.0126 (9)	0.0265 (8)
O5	0.0479 (7)	0.0950 (10)	0.0525 (7)	0.0144 (6)	0.0107 (5)	0.0287 (7)
O6	0.0518 (7)	0.0819 (9)	0.0592 (8)	0.0140 (6)	0.0006 (6)	0.0327 (7)
O7	0.0913 (11)	0.0988 (11)	0.0571 (8)	0.0192 (9)	−0.0071 (8)	0.0300 (8)
O8	0.1188 (14)	0.1410 (16)	0.0609 (9)	0.0613 (12)	0.0319 (9)	0.0334 (10)
C21A	0.134 (6)	0.142 (7)	0.042 (3)	−0.033 (5)	−0.013 (3)	0.021 (4)
C22A	0.075 (2)	0.061 (3)	0.072 (3)	0.0025 (17)	−0.0183 (16)	0.0174 (19)
C21B	0.112 (11)	0.054 (7)	0.160 (19)	0.039 (8)	−0.008 (9)	0.019 (8)
C22B	0.070 (4)	0.069 (6)	0.071 (5)	−0.001 (4)	−0.005 (3)	0.014 (4)
C23	0.0632 (13)	0.1015 (17)	0.0703 (14)	−0.0118 (12)	−0.0097 (11)	0.0184 (13)
C24	0.0488 (9)	0.0548 (10)	0.0595 (10)	−0.0009 (7)	0.0012 (8)	0.0207 (8)
C25	0.0538 (10)	0.0506 (9)	0.0537 (10)	0.0057 (7)	0.0103 (8)	0.0188 (8)
C26	0.0398 (8)	0.0496 (9)	0.0610 (10)	0.0078 (7)	0.0099 (7)	0.0297 (8)
C27	0.0411 (8)	0.0489 (9)	0.0534 (9)	0.0048 (7)	0.0012 (7)	0.0274 (7)
C28	0.0450 (9)	0.0517 (9)	0.0540 (9)	0.0097 (7)	0.0087 (7)	0.0256 (8)
C29	0.0385 (8)	0.0576 (10)	0.0636 (11)	0.0048 (7)	0.0055 (7)	0.0270 (8)
C30	0.0586 (12)	0.0989 (16)	0.0749 (13)	0.0302 (11)	0.0247 (10)	0.0333 (12)
N3	0.0459 (8)	0.0723 (10)	0.0775 (11)	0.0128 (7)	0.0157 (8)	0.0415 (9)
O9	0.0515 (7)	0.0899 (9)	0.0549 (7)	0.0189 (6)	0.0122 (6)	0.0260 (7)
O10	0.0462 (7)	0.0841 (9)	0.0559 (7)	0.0035 (6)	−0.0022 (6)	0.0309 (7)
O11	0.0399 (7)	0.1124 (12)	0.0902 (10)	0.0106 (7)	0.0049 (7)	0.0505 (9)
O12	0.0636 (9)	0.1155 (13)	0.0860 (11)	0.0232 (8)	0.0337 (8)	0.0380 (9)

Geometric parameters (Å, º) top

C1—C2	1.285 (4)	C16—N2	1.448 (2)
C1—H1A	0.9300	C17—O6	1.345 (2)
C1—H1B	0.9300	C17—C18	1.411 (2)
C2—C3	1.460 (4)	C18—O5	1.359 (2)
C2—H2	0.9300	C18—C19	1.374 (2)
C3—C4	1.512 (3)	C19—H19	0.9300
C3—H3A	0.9700	C20—O5	1.423 (2)
C3—H3B	0.9700	C20—H20A	0.9600
C4—C5	1.363 (3)	C20—H20B	0.9600
C4—C9	1.404 (3)	C20—H20C	0.9600
C5—C6	1.393 (3)	N2—O8	1.219 (2)
C5—H5	0.9300	N2—O7	1.240 (2)
C6—C7	1.392 (3)	O6—H6	0.83 (2)
C6—N1	1.449 (2)	C21A—C22A	1.206 (8)
C7—O2	1.344 (2)	C21A—H21A	0.9300
C7—C8	1.412 (2)	C21A—H21B	0.9300
C8—O1	1.355 (2)	C22A—C23	1.475 (5)
C8—C9	1.370 (2)	C22A—H22A	0.9300
C9—H9	0.9300	C21B—C22B	1.32 (2)
C10—O1	1.432 (2)	C21B—H21C	0.9300
C10—H10A	0.9600	C21B—H21D	0.9300
C10—H10B	0.9600	C22B—C23	1.320 (9)
C10—H10C	0.9600	C22B—H22B	0.9300
N1—O4	1.224 (2)	C23—C24	1.520 (3)
N1—O3	1.247 (2)	C23—H23A	0.9700
O2—H2O	0.91 (3)	C23—H23B	0.9700
C11A—C12A	1.293 (12)	C23—H23C	0.9700
C11A—H11A	0.9300	C23—H23D	0.9700
C11A—H11B	0.9300	C24—C25	1.373 (2)
C12A—C13	1.383 (5)	C24—C29	1.402 (3)
C12A—H12A	0.9300	C25—C26	1.395 (2)
C11B—C12B	1.39 (2)	C25—H25	0.9300
C11B—H11C	0.9300	C26—C27	1.389 (2)
C11B—H11D	0.9300	C26—N3	1.450 (2)
C12B—C13	1.351 (9)	C27—O10	1.341 (2)
C12B—H12B	0.9300	C27—C28	1.415 (2)
C13—C14	1.520 (3)	C28—O9	1.359 (2)
C13—H13A	0.9700	C28—C29	1.370 (2)
C13—H13B	0.9700	C29—H29	0.9300
C13—H13C	0.9700	C30—O9	1.423 (2)
C13—H13D	0.9700	C30—H30A	0.9600
C14—C15	1.364 (3)	C30—H30B	0.9600
C14—C19	1.404 (3)	C30—H30C	0.9600
C15—C16	1.397 (3)	N3—O12	1.219 (2)
C15—H15	0.9300	N3—O11	1.240 (2)
C16—C17	1.392 (2)	O10—H10	0.86 (3)

C2—C1—H1A	120.0	O6—C17—C16	126.40 (16)
C2—C1—H1B	120.0	O6—C17—C18	116.84 (15)
H1A—C1—H1B	120.0	C16—C17—C18	116.75 (15)
C1—C2—C3	127.5 (3)	O5—C18—C19	125.52 (16)
C1—C2—H2	116.2	O5—C18—C17	114.12 (14)
C3—C2—H2	116.2	C19—C18—C17	120.36 (16)
C2—C3—C4	113.5 (2)	C18—C19—C14	121.83 (17)
C2—C3—H3A	108.9	C18—C19—H19	119.1
C4—C3—H3A	108.9	C14—C19—H19	119.1
C2—C3—H3B	108.9	O5—C20—H20A	109.5
C4—C3—H3B	108.9	O5—C20—H20B	109.5
H3A—C3—H3B	107.7	H20A—C20—H20B	109.5
C5—C4—C9	118.99 (18)	O5—C20—H20C	109.5
C5—C4—C3	121.19 (18)	H20A—C20—H20C	109.5
C9—C4—C3	119.81 (18)	H20B—C20—H20C	109.5
C4—C5—C6	119.87 (17)	O8—N2—O7	121.72 (18)
C4—C5—H5	120.1	O8—N2—C16	119.09 (19)
C6—C5—H5	120.1	O7—N2—C16	119.18 (17)
C7—C6—C5	122.23 (16)	C18—O5—C20	117.02 (14)
C7—C6—N1	120.24 (18)	C17—O6—H6	101.5 (17)
C5—C6—N1	117.52 (17)	C22A—C21A—H21A	120.0
O2—C7—C6	125.82 (16)	C22A—C21A—H21B	120.0
O2—C7—C8	116.97 (16)	H21A—C21A—H21B	120.0
C6—C7—C8	117.20 (16)	C21A—C22A—C23	132.2 (6)
O1—C8—C9	125.18 (16)	C21A—C22A—H22A	113.9
O1—C8—C7	114.62 (16)	C23—C22A—H22A	113.9
C9—C8—C7	120.19 (16)	C22B—C21B—H21C	120.0
C8—C9—C4	121.50 (17)	C22B—C21B—H21D	120.0
C8—C9—H9	119.3	H21C—C21B—H21D	120.0
C4—C9—H9	119.3	C23—C22B—C21B	143.2 (12)
O1—C10—H10A	109.5	C23—C22B—H22B	108.4
O1—C10—H10B	109.5	C21B—C22B—H22B	108.4
H10A—C10—H10B	109.5	C22B—C23—C24	120.4 (4)
O1—C10—H10C	109.5	C22A—C23—C24	115.5 (2)
H10A—C10—H10C	109.5	C22A—C23—H23A	108.4
H10B—C10—H10C	109.5	C24—C23—H23A	108.4
O4—N1—O3	121.93 (19)	C22A—C23—H23B	108.4
O4—N1—C6	119.1 (2)	C24—C23—H23B	108.4
O3—N1—C6	118.96 (19)	H23A—C23—H23B	107.5
C8—O1—C10	117.66 (15)	C22B—C23—H23C	107.2
C7—O2—H2O	105.1 (17)	C24—C23—H23C	107.2
C12A—C11A—H11A	120.0	C22B—C23—H23D	107.2
C12A—C11A—H11B	120.0	C24—C23—H23D	107.2
H11A—C11A—H11B	120.0	H23C—C23—H23D	106.9
C11A—C12A—C13	126.5 (7)	C25—C24—C29	118.75 (16)
C11A—C12A—H12A	116.8	C25—C24—C23	120.96 (18)
C13—C12A—H12A	116.8	C29—C24—C23	120.28 (17)
C12B—C11B—H11C	120.0	C24—C25—C26	119.89 (16)
C12B—C11B—H11D	120.0	C24—C25—H25	120.1
H11C—C11B—H11D	120.0	C26—C25—H25	120.1
C13—C12B—C11B	134.0 (11)	C27—C26—C25	122.34 (15)
C13—C12B—H12B	113.0	C27—C26—N3	120.08 (15)
C11B—C12B—H12B	113.0	C25—C26—N3	117.58 (15)
C12B—C13—C14	118.1 (3)	O10—C27—C26	126.64 (15)
C12A—C13—C14	116.4 (2)	O10—C27—C28	116.39 (15)
C12A—C13—H13A	108.2	C26—C27—C28	116.96 (14)
C14—C13—H13A	108.2	O9—C28—C29	125.80 (15)
C12A—C13—H13B	108.2	O9—C28—C27	113.62 (14)
C14—C13—H13B	108.2	C29—C28—C27	120.58 (16)
H13A—C13—H13B	107.3	C28—C29—C24	121.47 (15)
C12B—C13—H13C	107.8	C28—C29—H29	119.3
C14—C13—H13C	107.8	C24—C29—H29	119.3
C12B—C13—H13D	107.8	O9—C30—H30A	109.5
C14—C13—H13D	107.8	O9—C30—H30B	109.5
H13C—C13—H13D	107.1	H30A—C30—H30B	109.5
C15—C14—C19	118.49 (17)	O9—C30—H30C	109.5
C15—C14—C13	121.91 (18)	H30A—C30—H30C	109.5
C19—C14—C13	119.59 (18)	H30B—C30—H30C	109.5
C14—C15—C16	120.02 (17)	O12—N3—O11	121.95 (16)
C14—C15—H15	120.0	O12—N3—C26	119.16 (16)
C16—C15—H15	120.0	O11—N3—C26	118.88 (16)
C17—C16—C15	122.55 (16)	C28—O9—C30	117.87 (14)
C17—C16—N2	119.58 (16)	C27—O10—H10	102.6 (17)
C15—C16—N2	117.87 (16)

C1—C2—C3—C4	−120.5 (3)	O6—C17—C18—C19	179.56 (15)
C2—C3—C4—C5	95.0 (3)	C16—C17—C18—C19	0.2 (2)
C2—C3—C4—C9	−84.5 (3)	O5—C18—C19—C14	179.73 (17)
C9—C4—C5—C6	0.1 (3)	C17—C18—C19—C14	0.1 (3)
C3—C4—C5—C6	−179.48 (18)	C15—C14—C19—C18	−0.1 (3)
C4—C5—C6—C7	−0.3 (3)	C13—C14—C19—C18	179.3 (2)
C4—C5—C6—N1	179.90 (16)	C17—C16—N2—O8	−173.68 (18)
C5—C6—C7—O2	−178.92 (16)	C15—C16—N2—O8	6.3 (3)
N1—C6—C7—O2	0.8 (3)	C17—C16—N2—O7	6.4 (3)
C5—C6—C7—C8	−0.3 (2)	C15—C16—N2—O7	−173.57 (17)
N1—C6—C7—C8	179.51 (14)	C19—C18—O5—C20	1.2 (3)
O2—C7—C8—O1	−0.1 (2)	C17—C18—O5—C20	−179.13 (16)
C6—C7—C8—O1	−178.89 (14)	C21B—C22B—C23—C24	−92.5 (19)
O2—C7—C8—C9	179.89 (15)	C21A—C22A—C23—C24	113.8 (7)
C6—C7—C8—C9	1.1 (2)	C22B—C23—C24—C25	2.5 (7)
O1—C8—C9—C4	178.59 (16)	C22A—C23—C24—C25	−45.2 (4)
C7—C8—C9—C4	−1.4 (3)	C22B—C23—C24—C29	−176.1 (7)
C5—C4—C9—C8	0.8 (3)	C22A—C23—C24—C29	136.1 (3)
C3—C4—C9—C8	−179.65 (18)	C29—C24—C25—C26	−0.2 (3)
C7—C6—N1—O4	−176.42 (16)	C23—C24—C25—C26	−178.83 (18)
C5—C6—N1—O4	3.4 (2)	C24—C25—C26—C27	−0.1 (3)
C7—C6—N1—O3	4.4 (3)	C24—C25—C26—N3	179.01 (15)
C5—C6—N1—O3	−175.79 (17)	C25—C26—C27—O10	−178.86 (15)
C9—C8—O1—C10	−2.6 (3)	N3—C26—C27—O10	2.0 (2)
C7—C8—O1—C10	177.44 (16)	C25—C26—C27—C28	0.4 (2)
C11B—C12B—C13—C14	100.3 (13)	N3—C26—C27—C28	−178.66 (14)
C11A—C12A—C13—C14	−105.3 (7)	O10—C27—C28—O9	−1.6 (2)
C12B—C13—C14—C15	175.2 (5)	C26—C27—C28—O9	179.02 (14)
C12A—C13—C14—C15	−132.1 (3)	O10—C27—C28—C29	178.92 (15)
C12B—C13—C14—C19	−4.2 (5)	C26—C27—C28—C29	−0.5 (2)
C12A—C13—C14—C19	48.6 (4)	O9—C28—C29—C24	−179.25 (16)
C19—C14—C15—C16	−0.1 (3)	C27—C28—C29—C24	0.1 (3)
C13—C14—C15—C16	−179.5 (2)	C25—C24—C29—C28	0.2 (3)
C14—C15—C16—C17	0.3 (3)	C23—C24—C29—C28	178.83 (19)
C14—C15—C16—N2	−179.68 (17)	C27—C26—N3—O12	−179.78 (16)
C15—C16—C17—O6	−179.69 (16)	C25—C26—N3—O12	1.1 (2)
N2—C16—C17—O6	0.3 (3)	C27—C26—N3—O11	1.1 (2)
C15—C16—C17—C18	−0.4 (2)	C25—C26—N3—O11	−178.04 (16)
N2—C16—C17—C18	179.66 (15)	C29—C28—O9—C30	−3.2 (3)
O6—C17—C18—O5	−0.1 (2)	C27—C28—O9—C30	177.35 (16)
C16—C17—C18—O5	−179.54 (14)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
O10—H10···O11	0.86 (3)	1.81 (3)	2.594 (2)	149 (2)
O6—H6···O7	0.83 (2)	1.83 (2)	2.584 (2)	152 (2)
O2—H2O···O3	0.91 (3)	1.78 (3)	2.587 (2)	146 (2)
C12A—H12A···O12	0.93	2.58	3.382 (4)	145
C12B—H12B···O3ⁱ	0.93	2.56	3.325 (8)	140
C9—H9···O7ⁱⁱ	0.93	2.59	3.394 (2)	145

Symmetry codes: (i) −x+1, −y+1, −z+1; (ii) −x+2, −y+1, −z+2.

Acknowledgements

The authors thank the Faculty of Science Mohammed V University in Rabat, Morocco, for the X-ray measurements.

References

Babu, S., Raghavamenon, A. C., Fronczek, F. R. & Uppu, R. M. (2009). Acta Cryst. E65, o2292–o2293. Web of Science CSD CrossRef IUCr Journals Google Scholar
Bruker (2016). APEX3 and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA. Google Scholar
Carrasco, A. H., Espinoza, C. L., Cardile, V., Gallardo, C., Cardona, W., Lombardo, L., Catalán, M. K., Cuellar, F. M. & Russo, A. (2008). J. Braz. Chem. Soc. 19, 543–548. Google Scholar
Carrasco, H., Raimondi, M., Svetaz, L., Di Liberto, M., Rodriguez, M. V., Espinoza, L., Madrid, A. & Zacchino, S. (2012). Molecules, 17, 1002–1024. CrossRef CAS PubMed Google Scholar
Carrasco-Altamirano, H., Espinoza-Catalán, L., Gallardo-Araya, C., Cardona-Villada, W., Ibañez, A. & Alvarez-Thon, L. (2006). Acta Cryst. E62, o1782–o1784. CrossRef IUCr Journals Google Scholar
Egorov, M., Delpech, B., Aubert, G., Cresteil, T., Garcia-Alvarez, M. C., Collin, P. & Marazano, C. (2014). Org. Biomol. Chem. 12, 1518–1524. CrossRef CAS PubMed Google Scholar
Farrugia, L. J. (2012). J. Appl. Cryst. 45, 849–854. Web of Science CrossRef CAS IUCr Journals Google Scholar
Groom, C. R., Bruno, I. J., Lightfoot, M. P. & Ward, S. C. (2016). Acta Cryst. B72, 171–179. Web of Science CrossRef IUCr Journals Google Scholar
Heredia, D. A., Larghi, E. L. & Kaufman, T. S. (2016). Eur. J. Org. Chem. pp. 1397–1404. CrossRef Google Scholar
Hidalgo, M. E., De la Rosa, C., Carrasco, H., Cardona, W., Gallardo, C. & Espinoza, L. (2009). Quím. Nova, 32, 1467–1470. CAS Google Scholar
Kaufman, T. S. (2015). J. Braz. Chem. Soc. 26, 1055–1085. CAS Google Scholar
Krause, L., Herbst-Irmer, R., Sheldrick, G. M. & Stalke, D. (2015). J. Appl. Cryst. 48, 3–10. Web of Science CSD CrossRef ICSD CAS IUCr Journals Google Scholar
Macrae, C. F., Sovago, I., Cottrell, S. J., Galek, P. T. A., McCabe, P., Pidcock, E., Platings, M., Shields, G. P., Stevens, J. S., Towler, M. & Wood, P. A. (2020). J. Appl. Cryst. 53, 226–235. Web of Science CrossRef CAS IUCr Journals Google Scholar
McKinnon, J. J., Jayatilaka, D. & Spackman, M. A. (2007). Chem. Commun. 3814–3816. Google Scholar
Sheldrick, G. M. (2015a). Acta Cryst. A71, 3–8. Web of Science CrossRef IUCr Journals Google Scholar
Sheldrick, G. M. (2015b). Acta Cryst. C71, 3–8. Web of Science CrossRef IUCr Journals Google Scholar
Spackman, M. A. & Jayatilaka, D. (2009). CrystEngComm, 11, 19–32. Web of Science CrossRef CAS Google Scholar
Turner, M., McKinnon, J., Wolff, S., Grimwood, D., Spackman, P., Jayatilaka, D. & Spackman, M. (2017). CrystalExplorer17. University of Western Australia. Google Scholar
Vusak, V., Vusak, D., Molcanov, K. & Ernest, M. (2020). Acta Cryst. E76, 239–244. CrossRef IUCr Journals Google Scholar
Westrip, S. P. (2010). J. Appl. Cryst. 43, 920–925. Web of Science CrossRef CAS IUCr Journals Google Scholar

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