research communications
of 1-[(4-methylbenzene)sulfonyl]pyrrolidine
aDepartment of Chemistry, 1 Campus Dr., Grand Valley State University, Allendale, MI 49401, USA, and bCenter for Crystallographic Research, Michigan State University, Department of Chemistry and Chemical Biology, East Lansing, MI 48824, USA
*Correspondence e-mail: ngassaf@gvsu.edu
The molecular structure of the title compound, C11H15NO2S, features a sulfonamide group with S=O bond lengths of 1.4357 (16) and 1.4349 (16) Å, an S—N bond length of 1.625 (2) Å, and an S—C bond length of 1.770 (2) Å. When viewing the molecule down the S—N bond, both N—C bonds of the pyrrolidine ring are oriented gauche to the S—C bond with torsion angles of −65.6 (2)° and 76.2 (2)°. The features both intra- and intermolecular C—H⋯O hydrogen bonds, as well as intermolecular C—H⋯π and π–π interactions, leading to the formation of sheets parallel to the ac plane.
Keywords: crystal structure; sulfonamide; π–π interaction; C—H⋯O hydrogen bonds; C—H⋯π interactions; polymorphism.
CCDC reference: 1983920
1. Chemical context
are of significant value in organic chemistry because of their therapeutic properties. These molecules are referred to in the pharmaceutical industry as sulfa drugs. This class of drugs has been widely used in various pharmaceutical applications owing to their antibacterial, antiviral, antimalarial, antifungal, anticancer, antidepressant, and other properties (Apaydın & Török, 2019N-containing heterocycles have found many uses in pharmaceutical and materials sciences, and as a result they have attracted the attention of many in the synthetic community. Numerous synthetic methods leading to N-containing heterocycles have been reported (Jiang & Ma, 2013). Notwithstanding, because of the importance of N-containing heterocycles, new and versatile synthetic methods are still desirable. The pyrrolidine-4-methylbenzenesulfonamide moiety is found in a variety of biologically important compounds that exhibit anti-inflammatory properties. L-proline-derived 4-methylbenzenesulfonamides (Fig. 1) have been reported to exhibit anti-inflammatory activity against Trypanosoma brucei gambiense (Ugwu et al., 2018). Furthermore, these compounds can permeate the blood-brain barrier and hence can be used in treating inflammation of the brain (Ugwu et al., 2017).
Generally, et al., 2018). Efficient methods from the literature involve the base-catalyzed sulfonylation of using sulfonyl halides (Yan et al., 2007) or (De Luca & Giacomelli, 2008) as electrophiles. The title compound, along with some related analogs, has been synthesized previously (Ohwada, et al., 1998). Recently, we have discovered a more efficient method using aqueous potassium carbonate as the base. This method avoids the use of a phase-transfer catalyst by using tetrahydrofuran as a water-miscible solvent. An increased rate of reaction and yield of sulfonamide compounds produced from a wide range of has been observed. These reaction conditions produced the title compound in a 91% yield, compared to the 58% yield previously reported.
are synthesized by an analogous nucleophilic acyl-substitution reaction between an and a nucleophilic amine (PatelIn a continuation of our research group's ongoing interest in synthesizing small sulfonamide molecules that mimic the structural motifs of known sulfonamide drug candidates, we synthesized the title compound, C11H15NO2S, and determined its from single-crystal X-ray diffraction data.
2. Structural commentary
The molecular structure of the title compound is shown in Fig. 2. The S1=O1 and S1=O2 bond lengths are 1.4357 (16) and 1.4349 (16) Å, which is in line with known values. The S1—C5 and S1—N1 bond lengths are 1.770 (2) and 1.625 (2) Å, respectively, with an N1—S1—C5 bond angle of 107.66 (9)°. The τ4 descriptor for fourfold coordination around the sulfur atom, S1, is 0.94, indicating a slightly distorted tetrahedron (ideal values are 0 for square-planar, 0.85 for trigonal–pyramidal, and 1 for tetrahedral coordination; Yang et al., 2007). Both C—N bonds of the pyrrolidine ring are oriented gauche to the S1—C5 bond with torsion angles C5—S1—N1—C1 = −65.62 (18)° and C5—S1—N1—C4 = 76.16 (19)°. A of the five-membered pyrrolidine ring pucker gives a puckering amplitude (Q2) parameter of 0.352 (3) Å and a φ2 parameter of 262.2 (4)°. Consequently, this ring is in a half-chair conformation with a twist along the C2—C3 bond. Lastly, an intramolecular C—H⋯O contact (Sutor, 1958,1962,1963; Steiner, 1996) is present between H10 and O2 with an H⋯A distance of 2.54 Å (Table 1).
3. Supramolecular features
In the π–π interactions, C—H⋯O hydrogen bonds, and C—H⋯π interactions (Fig. 3, Table 1). The C—H⋯O hydrogen bond is formed between an aromatic C—H group (C6—H6) and one of the sulfonamide O atoms (O1). The C—H⋯π interaction is between the methyl group (C11—H11C) and a symmetry-derived ring (C5–C10; symmetry code: –x, –y + 1, –z + 1). The π–π interaction has a centroid-to-centroid distance of 3.8162 (15) Å with a slippage of 1.307 Å. The result of these interactions is the formation of sheets that lie in the ac plane (Fig. 4).
of the title compound, molecules are linked by4. Database survey
The Cambridge Structural Database (CSD, Version 5.40, August 2019; Groom et al., 2016) contains hundreds of structures that comprise a p-toluenesulfonamide group bearing a pyrrolidine ring. Included in this list is another crystal-structure determination of the title compound (refcode: BABLEV; Ohwada et al., 1998), which also crystallizes in the P Unfortunately, coordinates were not deposited for this structure at that time, so we are unable to say whether the title compound is a new packing polymorph or a new conformational polymorph. The of BABLEV is a = 8.241, b = 2.671, c = 9.240 Å, α = 76.550, β = 63.800, γ = 87.880° with a volume of 574.55 Å3. The theoretical X-ray density values for each structure are similar, with 1.30 g cm−3 for BABLEV and 1.36 g cm−3 for the title compound. Thus, the more densely packed structure reported here is likely the more thermodynamically stable form.
A selection of other structures in the CSD that are closely related to the title compound are BOKPEX (Rao & Chan, 2008), GAWDAK (Chen et al., 2005), VECTUT (Sherman et al., 2007) and YIRCOS (Wang & Peng, 2008). These structures were chosen for comparison because they have relatively simple substituents on the pyrrolidine ring. In their paper describing the structure of GAWDAK, the authors report that this crystal also features both intra- and intermolecular hydrogen bonds in the solid state.
5. Synthesis and crystallization
The title compound was prepared by the dropwise addition of p-toluenesulfonyl chloride (1.00 g, 5.25 mmol) to a stirring mixture of pyrrolidine (0.48 ml, 5.90 mmol) and 10 ml of tetrahydrofuran. This was followed by the dropwise addition of 0.59 M aqueous potassium carbonate (10 ml, 5.90 mmol) and the mixture was stirred at room temperate for 6 h. Upon acidification with 5 M HCl, a white precipitate was isolated by vacuum filtration to give the crude sulfonamide product. The crude product was dissolved in hot ethanol and filtered. The filtrate was transferred to a scintillation vial and crystallized upon standing for 24 h to afford colorless crystals, filtered from the mother liquor (yield 91%; m.p. 405–407 K).
6. Refinement
Crystal data, data collection and structure . Hydrogen atoms bonded to carbon atoms were placed in calculated positions and refined as riding: C—H = 0.95–1.00 Å with Uiso(H) = 1.2Ueq(C) for methylene groups and aromatic hydrogen atoms, and Uiso(H) = 1.5Ueq(C) for methyl groups.
details are summarized in Table 2Supporting information
CCDC reference: 1983920
https://doi.org/10.1107/S205698902000208X/wm5540sup1.cif
contains datablock I. DOI:Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S205698902000208X/wm5540Isup2.hkl
Data collection: APEX2 (Bruker, 2013); cell
SAINT (Bruker, 2013); data reduction: SAINT (Bruker, 2013); program(s) used to solve structure: ShelXT (Sheldrick, 2015); program(s) used to refine structure: OLEX2 (Dolomanov et al., 2009; Bourhis et al., 2015); molecular graphics: OLEX2 (Dolomanov et al., 2009; Bourhis et al., 2015); software used to prepare material for publication: CrystalMaker (Palmer, 2007).C11H15NO2S | Z = 2 |
Mr = 225.30 | F(000) = 240 |
Triclinic, P1 | Dx = 1.364 Mg m−3 |
a = 7.5347 (1) Å | Cu Kα radiation, λ = 1.54178 Å |
b = 8.2581 (1) Å | Cell parameters from 3988 reflections |
c = 9.6157 (1) Å | θ = 4.7–68.2° |
α = 77.876 (1)° | µ = 2.46 mm−1 |
β = 86.132 (1)° | T = 173 K |
γ = 69.682 (1)° | Plate, colourless |
V = 548.56 (1) Å3 | 0.22 × 0.16 × 0.04 mm |
Bruker APEXII CCD diffractometer | 1715 reflections with I > 2σ(I) |
φ and ω scans | Rint = 0.033 |
Absorption correction: multi-scan (SADABS; Krause et al., 2015) | θmax = 68.3°, θmin = 4.7° |
Tmin = 0.631, Tmax = 0.753 | h = −9→9 |
7120 measured reflections | k = −9→9 |
1944 independent reflections | l = −11→11 |
Refinement on F2 | Primary atom site location: dual |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.041 | H-atom parameters constrained |
wR(F2) = 0.120 | w = 1/[σ2(Fo2) + (0.0698P)2 + 0.2666P] where P = (Fo2 + 2Fc2)/3 |
S = 1.09 | (Δ/σ)max < 0.001 |
1944 reflections | Δρmax = 0.53 e Å−3 |
137 parameters | Δρmin = −0.33 e Å−3 |
0 restraints |
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes. |
x | y | z | Uiso*/Ueq | ||
S1 | 0.56522 (7) | 0.19952 (7) | 0.20258 (5) | 0.0225 (2) | |
O1 | 0.6545 (2) | 0.2957 (2) | 0.09657 (16) | 0.0302 (4) | |
O2 | 0.6789 (2) | 0.0403 (2) | 0.29321 (17) | 0.0313 (4) | |
N1 | 0.4193 (3) | 0.1465 (2) | 0.11936 (19) | 0.0239 (4) | |
C1 | 0.3110 (3) | 0.0415 (3) | 0.2046 (2) | 0.0283 (5) | |
H1A | 0.263738 | 0.084458 | 0.293341 | 0.034* | |
H1B | 0.389620 | −0.084784 | 0.228939 | 0.034* | |
C2 | 0.1485 (3) | 0.0702 (3) | 0.1065 (3) | 0.0353 (6) | |
H2A | 0.184331 | −0.016766 | 0.043620 | 0.042* | |
H2B | 0.035011 | 0.061924 | 0.161429 | 0.042* | |
C3 | 0.1137 (4) | 0.2554 (4) | 0.0214 (4) | 0.0511 (8) | |
H3A | 0.051601 | 0.272209 | −0.070616 | 0.061* | |
H3B | 0.032278 | 0.344031 | 0.074899 | 0.061* | |
C4 | 0.3053 (4) | 0.2719 (3) | −0.0018 (3) | 0.0357 (6) | |
H4A | 0.359019 | 0.240275 | −0.093216 | 0.043* | |
H4B | 0.299424 | 0.393584 | −0.001822 | 0.043* | |
C5 | 0.4298 (3) | 0.3438 (3) | 0.3132 (2) | 0.0225 (5) | |
C6 | 0.3318 (3) | 0.5190 (3) | 0.2538 (2) | 0.0287 (5) | |
H6 | 0.342164 | 0.563001 | 0.155156 | 0.034* | |
C7 | 0.2192 (3) | 0.6284 (3) | 0.3400 (3) | 0.0331 (6) | |
H7 | 0.149316 | 0.747265 | 0.299159 | 0.040* | |
C8 | 0.2063 (3) | 0.5674 (4) | 0.4859 (3) | 0.0334 (6) | |
C9 | 0.3052 (4) | 0.3933 (4) | 0.5423 (3) | 0.0359 (6) | |
H9 | 0.296907 | 0.349698 | 0.641258 | 0.043* | |
C10 | 0.4167 (3) | 0.2805 (3) | 0.4575 (2) | 0.0296 (5) | |
H10 | 0.483503 | 0.160696 | 0.497955 | 0.035* | |
C11 | 0.0852 (4) | 0.6900 (4) | 0.5788 (3) | 0.0516 (8) | |
H11A | 0.096515 | 0.806829 | 0.547317 | 0.077* | |
H11B | 0.127699 | 0.643344 | 0.677852 | 0.077* | |
H11C | −0.047268 | 0.699432 | 0.571301 | 0.077* |
U11 | U22 | U33 | U12 | U13 | U23 | |
S1 | 0.0196 (3) | 0.0255 (3) | 0.0225 (3) | −0.0078 (2) | −0.00028 (19) | −0.0042 (2) |
O1 | 0.0262 (8) | 0.0370 (10) | 0.0289 (9) | −0.0143 (7) | 0.0064 (6) | −0.0056 (7) |
O2 | 0.0243 (8) | 0.0313 (9) | 0.0345 (9) | −0.0062 (7) | −0.0048 (7) | −0.0023 (7) |
N1 | 0.0240 (9) | 0.0269 (10) | 0.0223 (9) | −0.0101 (8) | −0.0003 (7) | −0.0057 (7) |
C1 | 0.0278 (11) | 0.0262 (12) | 0.0327 (12) | −0.0117 (9) | −0.0001 (9) | −0.0051 (9) |
C2 | 0.0280 (12) | 0.0392 (15) | 0.0423 (15) | −0.0142 (10) | −0.0049 (10) | −0.0095 (11) |
C3 | 0.0361 (15) | 0.0509 (18) | 0.0596 (19) | −0.0150 (13) | −0.0176 (13) | 0.0090 (14) |
C4 | 0.0395 (14) | 0.0379 (14) | 0.0281 (13) | −0.0140 (11) | −0.0081 (10) | 0.0005 (10) |
C5 | 0.0217 (10) | 0.0269 (12) | 0.0224 (11) | −0.0113 (9) | −0.0004 (8) | −0.0069 (8) |
C6 | 0.0318 (12) | 0.0295 (13) | 0.0267 (12) | −0.0141 (10) | 0.0011 (9) | −0.0039 (9) |
C7 | 0.0316 (12) | 0.0262 (13) | 0.0443 (15) | −0.0114 (10) | 0.0041 (10) | −0.0118 (10) |
C8 | 0.0288 (12) | 0.0453 (15) | 0.0383 (14) | −0.0212 (11) | 0.0072 (10) | −0.0215 (11) |
C9 | 0.0370 (13) | 0.0553 (17) | 0.0224 (12) | −0.0224 (12) | 0.0024 (10) | −0.0119 (11) |
C10 | 0.0302 (12) | 0.0361 (14) | 0.0225 (11) | −0.0122 (10) | −0.0032 (9) | −0.0035 (9) |
C11 | 0.0418 (15) | 0.070 (2) | 0.0624 (19) | −0.0267 (15) | 0.0161 (14) | −0.0471 (17) |
S1—O1 | 1.4357 (16) | C4—H4B | 0.9900 |
S1—O2 | 1.4349 (16) | C5—C6 | 1.390 (3) |
S1—N1 | 1.6248 (18) | C5—C10 | 1.386 (3) |
S1—C5 | 1.770 (2) | C6—H6 | 0.9500 |
N1—C1 | 1.481 (3) | C6—C7 | 1.382 (3) |
N1—C4 | 1.476 (3) | C7—H7 | 0.9500 |
C1—H1A | 0.9900 | C7—C8 | 1.397 (4) |
C1—H1B | 0.9900 | C8—C9 | 1.379 (4) |
C1—C2 | 1.518 (3) | C8—C11 | 1.511 (3) |
C2—H2A | 0.9900 | C9—H9 | 0.9500 |
C2—H2B | 0.9900 | C9—C10 | 1.386 (3) |
C2—C3 | 1.517 (4) | C10—H10 | 0.9500 |
C3—H3A | 0.9900 | C11—H11A | 0.9800 |
C3—H3B | 0.9900 | C11—H11B | 0.9800 |
C3—C4 | 1.495 (4) | C11—H11C | 0.9800 |
C4—H4A | 0.9900 | ||
O1—S1—N1 | 106.88 (9) | N1—C4—H4B | 110.9 |
O1—S1—C5 | 108.04 (10) | C3—C4—H4A | 110.9 |
O2—S1—O1 | 119.67 (10) | C3—C4—H4B | 110.9 |
O2—S1—N1 | 106.48 (10) | H4A—C4—H4B | 108.9 |
O2—S1—C5 | 107.59 (10) | C6—C5—S1 | 119.68 (17) |
N1—S1—C5 | 107.66 (9) | C10—C5—S1 | 120.00 (18) |
C1—N1—S1 | 118.02 (14) | C10—C5—C6 | 120.3 (2) |
C4—N1—S1 | 120.69 (16) | C5—C6—H6 | 120.4 |
C4—N1—C1 | 110.89 (17) | C7—C6—C5 | 119.2 (2) |
N1—C1—H1A | 111.1 | C7—C6—H6 | 120.4 |
N1—C1—H1B | 111.1 | C6—C7—H7 | 119.4 |
N1—C1—C2 | 103.35 (18) | C6—C7—C8 | 121.3 (2) |
H1A—C1—H1B | 109.1 | C8—C7—H7 | 119.4 |
C2—C1—H1A | 111.1 | C7—C8—C11 | 120.4 (3) |
C2—C1—H1B | 111.1 | C9—C8—C7 | 118.4 (2) |
C1—C2—H2A | 111.1 | C9—C8—C11 | 121.2 (3) |
C1—C2—H2B | 111.1 | C8—C9—H9 | 119.3 |
H2A—C2—H2B | 109.1 | C8—C9—C10 | 121.3 (2) |
C3—C2—C1 | 103.2 (2) | C10—C9—H9 | 119.3 |
C3—C2—H2A | 111.1 | C5—C10—C9 | 119.5 (2) |
C3—C2—H2B | 111.1 | C5—C10—H10 | 120.2 |
C2—C3—H3A | 110.7 | C9—C10—H10 | 120.2 |
C2—C3—H3B | 110.7 | C8—C11—H11A | 109.5 |
H3A—C3—H3B | 108.8 | C8—C11—H11B | 109.5 |
C4—C3—C2 | 105.2 (2) | C8—C11—H11C | 109.5 |
C4—C3—H3A | 110.7 | H11A—C11—H11B | 109.5 |
C4—C3—H3B | 110.7 | H11A—C11—H11C | 109.5 |
N1—C4—C3 | 104.3 (2) | H11B—C11—H11C | 109.5 |
N1—C4—H4A | 110.9 | ||
S1—N1—C1—C2 | 161.32 (16) | C1—N1—C4—C3 | 6.5 (3) |
S1—N1—C4—C3 | −137.8 (2) | C1—C2—C3—C4 | 36.6 (3) |
S1—C5—C6—C7 | 176.88 (17) | C2—C3—C4—N1 | −26.6 (3) |
S1—C5—C10—C9 | −177.89 (17) | C4—N1—C1—C2 | 16.0 (2) |
O1—S1—N1—C1 | 178.52 (15) | C5—S1—N1—C1 | −65.62 (18) |
O1—S1—N1—C4 | −39.71 (19) | C5—S1—N1—C4 | 76.16 (19) |
O1—S1—C5—C6 | 38.27 (19) | C5—C6—C7—C8 | 1.8 (3) |
O1—S1—C5—C10 | −143.93 (18) | C6—C5—C10—C9 | −0.1 (3) |
O2—S1—N1—C1 | 49.53 (18) | C6—C7—C8—C9 | −1.6 (3) |
O2—S1—N1—C4 | −168.70 (17) | C6—C7—C8—C11 | 178.9 (2) |
O2—S1—C5—C6 | 168.76 (16) | C7—C8—C9—C10 | 0.5 (3) |
O2—S1—C5—C10 | −13.4 (2) | C8—C9—C10—C5 | 0.3 (3) |
N1—S1—C5—C6 | −76.84 (19) | C10—C5—C6—C7 | −0.9 (3) |
N1—S1—C5—C10 | 100.97 (19) | C11—C8—C9—C10 | −179.9 (2) |
N1—C1—C2—C3 | −31.6 (3) |
Cg2 is the centroid of the C5–C10 ring. |
D—H···A | D—H | H···A | D···A | D—H···A |
C6—H6···O1i | 0.95 | 2.46 | 3.406 (3) | 174 |
C10—H10···O2 | 0.95 | 2.54 | 2.917 (3) | 104 |
C11—H11C···Cg2ii | 0.98 | 2.73 | 3.614 (3) | 150 |
Symmetry codes: (i) −x+1, −y+1, −z; (ii) −x, −y+1, −z+1. |
Acknowledgements
The authors thank Pfizer, Inc. for the donation of a Varian INOVA 400 FT NMR spectrometer. The CCD-based X-ray diffractometers at Michigan State University were upgraded and/or replaced by departmental funds.
Funding information
Funding for this research was provided by: National Science Foundation (grant No. MRI CHE-1725699); Grand Valley State University Chemistry Department's Weldon Fund.
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