Different conformations and packing motifs in the crystal structures of four thio­phene–carbohydrazide–pyridine derivatives

Garbutt, J.L.; Costa, C.F. da; deSouza, M.V.N. deSouza; Wardell, S.M.S.V.; Wardell, J.L.; Harrison, W.T.A.

doi:10.1107/S2056989022005151

research communications

CRYSTALLOGRAPHIC
COMMUNICATIONS

ISSN: 2056-9890

Volume 78| Part 6| June 2022| Pages 619-624

https://doi.org/10.1107/S2056989022005151

Open

access

Different conformations and packing motifs in the crystal structures of four thiophene–carbohydrazide–pyridine derivatives

Jennifer L. Garbutt,^a Cristiane F. da Costa,^b Marcus V. N. deSouza,^b Solange M. S. V. Wardell,^c James L. Wardell ^a and William T. A. Harrison ^a ^*

^aDepartment of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, ^bFundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil, and ^cCHEMSOL, 1 Harcourt Road, Aberdeen AB15 5NY, Scotland
^*Correspondence e-mail: w.harrison@abdn.ac.uk

Edited by M. Zeller, Purdue University, USA (Received 11 May 2022; accepted 12 May 2022; online 17 May 2022)

The crystal structures of four thiophene–carbohydrazide–pyridine derivatives, viz. N′-[(E)-pyridin-3-ylmethylidene]thiophene-2-carbohydrazide, C₁₁H₉N₃OS, (I), N′-[(E)-pyridin-2-ylmethylidene]thiophene-2-carbohydrazide, C₁₁H₉N₃OS, (II), N-methyl-N′-[(E)-pyridin-2-ylmethylidene]thiophene-2-carbohydrazide, C₁₂H₁₁N₃OS, (III) and N′-[(E)-pyridin-2-ylmethylidene]-2-(thiophen-2-yl)ethanohydrazide, C₁₂H₁₁N₃OS, (IV) are described. The dihedral angles between the thiophene ring and the pyridine ring are 21.4 (2), 15.42 (14), 4.97 (8) and 83.52 (13)° for (I)–(IV), respectively. The thiophene ring in (IV) is disordered over two orientations in a 0.851 (2):0.149 (2) ratio. Key features of the packing include N—H⋯N_p (p = pyridine) hydrogen bonds in (I), which generate C(7) chains propagating in the [001] direction; N—H⋯N_p links also feature in (II), but in this case they lead to C(6) [001] chains; in (IV), classical amide (C4) N—H⋯O links result in [010] chains; in every case adjacent molecules in the chains are related by 2₁ screw axes. There are no classical hydrogen bonds in the extended structure of (III). Various weak C—H⋯X (X = O, N, S) interactions occur in each structure, but no aromatic π–π stacking is evident. The Hirshfeld surfaces and fingerprint plots for (I)–(IV) are compared.

Keywords: crystal structure; thiophene; carbohydrazide; pyridine.

CCDC references: 2172437; 2172436; 2172435; 2172434

1. Chemical context

Various thiophene–carbohydrazide derivatives containing a T—C(=O)—NH—N=CH—R (T = thiophene ring) building unit have been previously investigated by some of us for their anti-cancer (Cardoso et al., 2017 ) and anti-tuberculosis (Cardoso et al., 2014 , 2016a ) properties. Other workers have reported their analgesic activities (Lima et al., 2000 ) and their potential uses as tunable photo switches (van Dijken et al., 2015 ). The use of these compounds as multi-dentate chelating ligands has been described by Gholivand et al. (2016 ) and Abbas et al. (2021 ).

In a continuation of our earlier work on this family of compounds (Cardoso et al., 2016b ,c ), we now describe the crystal structures and Hirshfeld surfaces of N′-[(E)-pyridin-3-ylmethylidene]thiophene-2-carbohydrazide, C₁₁H₉N₃OS (I), N′-[(E)-pyridin-2-ylmethylidene]thiophene-2-carbohydrazide, C₁₁H₉N₃OS (II), N-methyl-N′-[(E)-pyridin-2-ylmethylidene]thiophene-2-carbohydrazide, C₁₂H₁₁N₃OS (III) and N′-[(E)-pyridin-2-ylmethylidene]-2-(thiophen-2-yl)ethanohydrazide, C₁₂H₁₁N₃OS (IV). Compounds (I) and (II) are positional isomers, differing in the location of the N atom of the pyridine ring, (III) is a methylated derivative of (II) and (IV) has a methylene group inserted between the thiophene ring and the carboyhdrazide grouping compared to (I).

2. Structural commentary

The molecular structures of (I)–(IV) are shown in Figs. 1–4 , respectively and they all confirm the structures (atomic connectivities) postulated in the previous studies noted in the synthesis section: each compound crystallizes with one molecule in the asymmetric unit and there is no suggestion that any of these compounds exist in the `enol' —C(OH)=N— tautomer in the solid state.

Figure 1
The molecular structure of (I)

showing 50% displacement ellipsoids.

Figure 2
The molecular structure of (II)

showing 50% displacement ellipsoids.

Figure 3
The molecular structure of (III)

showing 50% displacement ellipsoids. The short C—H⋯S contact is indicated by a double-dashed line.

Figure 4
The molecular structure of (IV)

showing 50% displacement ellipsoids. The minor disorder component of the thiophene ring is shown with pink bonds.

In (I) (Fig. 1), the conformation about the N2=C6 bond [1.280 (5) Å] is E and the C5—N1—N2—C6 torsion angle is 175.1 (4)°. The oxygen atom of the carbonyl group and the sulfur atom of the thiophene ring lie on the same side of the molecule [S1—C4—C5—O1 = −4.9 (6)°] whereas atom N3 of the pyridine ring lies on the opposite side. The dihedral angle between the thiophene and pyridine rings is 21.4 (2)° and the largest twist in the molecule occurs about the C6—C7 bond [N2—C6—C7—C8 = −11.8 (7)°]. The N1—N2 bond length of 1.384 (5) Å in (I) is significantly shorter than a typical N—N single bond (∼1.44 Å), which suggests substantial delocalization of electrons with the adjacent C5=O1 carbonyl group and the N2=C6 double bond, as observed previously for related compounds (Cardoso et al., 2016c). Otherwise, the bond lengths and angles in (I) may be regarded as unexceptional.

In (II) (Fig. 2), the N2=C6 double bond [1.284 (3) Å] is also in an E configuration and C5—N1—N2—C6 = 173.74 (19)° but unlike (I), atoms O1 and S1 lie on opposite sides of the molecule [S1—C4—C5—O1 = −170.67 (17)°] and N3 lies on the same side as O1. The dihedral angle between the aromatic rings is 15.42 (14)° and the most significant twist occurs about the C5—N1 bond [C4—C5—N1—N2 = 12.0 (3)°]. The C8—H8 bond of the pyridine ring points towards S1 but with H⋯S = 3.22 Å (sum of van der Waals radii = 3.00 Å) we consider it to be too long to be regarded as an intramolecular hydrogen bond.

Compound (III) (Fig. 3) is the N-methylated derivative of (II): the N2=C7 bond [1.2815 (17) Å] has an E configuration and C5—N1—N2—C7 = 179.40 (12)°. As with (II), O1 and S1 lie on opposite sides of the molecule [S1—C4—C5—O1 = 178.88 (10)° and N3 lies on the same side as O1. The dihedral angle between the C1–C4/S1 and C8–C12/N3 rings is 4.97 (8)°: most of this twist appear to be about the C7—C8 bond [N2—C7—C8—C9 = −4.8 (2)°] although the whole molecule is close to flat [r.m.s. deviation for the 17 non-H atoms = 0.065 Å]. In this case, the short intramolecular H⋯S contact between C9—H9 and S1 is 2.84 Å (C—H⋯S = 155°), considerably shorter than the equivalent contact in (II), and reasonable for this type of weak interaction (Ghosh et al., 2020 ).

In (IV) (Fig. 4), the thiophene ring was modelled with `flip' disorder (∼180° rotation about the C4—C5 bond) in a 0.851 (2): 0.149 (2) ratio, which is a common structural feature for this moiety (Cardoso et al., 2016c). Once again, the configuration of the N2=C7 double bond [1.281 (2) Å] is E and C6 and C7 are close to anti about the N—N bond [C6—N1—N2—C7 = −177.90 (14)°]. The dihedral angle between the aromatic rings (major disorder conformation for the thiophene moiety) in (IV) of 83.52 (13)° indicates near perpendicularity, which is quite different to the other compounds described here, presumably because the molecule has additional conformational flexibility about the C—C single bonds associated with the C5 methylene group [C3—C4—C5—C6 = 93.8 (6)°; C4—C5—C6—N1 = 144.72 (14)°].

3. Supramolecular features

Geometrical data for the directional intermolecular interactions in (I)–(IV) are listed in Tables 1–4 , respectively. The most significant features in the packing of (I) and (II) are N—H⋯N_p (p = pyridine) hydrogen bonds: in the former, these links generate [001] C(7) chains (Fig. 5), with adjacent molecules in the chain related by the 2₁ screw axis. In (II), the equivalent interaction also leads to [001] chains (Fig. 6) generated by the 2₁ screw axis but here the graph-set motif is C(6). The packing for (IV) features classical C(4) amide N—H⋯O hydrogen bonds (Fig. 7) leading to [010] chains generated once again by a 2₁ screw axis. There are obviously no classical hydrogen bonds in the extended structure of (III) and the only possible directional intermolecular contact identified is a very weak C—H⋯N_p link arising from the N-methyl group. The structures of (I), (II) and (IV) also feature various C—H⋯X (X = N, O, S) interactions although these are presumably very weak, given their H⋯X lengths.

Table 1
Hydrogen-bond geometry (Å, °) for (I)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1N⋯N3ⁱ	0.87 (5)	2.14 (5)	2.995 (5)	166 (4)
C1—H1⋯O1ⁱⁱ	0.95	2.53	3.471 (6)	171
C3—H3⋯N3ⁱ	0.95	2.61	3.479 (6)	152
C6—H6⋯N3ⁱ	0.95	2.59	3.410 (6)	145
C9—H9⋯O1ⁱⁱⁱ	0.95	2.66	3.397 (5)	135
C11—H11⋯N2^iv	0.95	2.57	3.481 (6)	160
Symmetry codes: (i) $[-x, -y, z-{\script{1\over 2}}]$ ; (ii) $[-x+1, -y+1, z-{\script{1\over 2}}]$ ; (iii) $[-x+1, -y, z+{\script{1\over 2}}]$ ; (iv) $[x-{\script{1\over 2}}, -y, z]$ .

Table 2
Hydrogen-bond geometry (Å, °) for (II)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1N⋯N3ⁱ	0.98 (3)	2.03 (3)	3.013 (3)	177 (3)
C1—H1⋯O1ⁱⁱ	0.95	2.48	3.101 (3)	123
C2—H2⋯O1ⁱⁱⁱ	0.95	2.64	3.410 (3)	139
Symmetry codes: (i) $[-x+1, -y+1, z+{\script{1\over 2}}]$ ; (ii) $[-x+{\script{3\over 2}}, y-{\script{1\over 2}}, z-{\script{1\over 2}}]$ ; (iii) $[-x+{\script{3\over 2}}, y-{\script{1\over 2}}, z+{\script{1\over 2}}]$ .

Table 3
Hydrogen-bond geometry (Å, °) for (III)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C9—H9⋯S1	0.95	2.84	3.7217 (13)	155
C6—H6C⋯N3ⁱ	0.98	2.61	3.3499 (18)	132
Symmetry code: (i) $[-x+{\script{1\over 2}}, y+{\script{1\over 2}}, -z+{\script{1\over 2}}]$ .

Table 4
Hydrogen-bond geometry (Å, °) for (IV)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N1—H1N⋯O1ⁱ	0.88 (2)	2.00 (2)	2.8628 (18)	164.9 (18)
C3—H3⋯N1ⁱⁱ	0.95	2.78	3.718 (7)	172
C5—H5B⋯O1ⁱ	0.99	2.64	3.307 (2)	125
C7—H7⋯S1Bⁱ	0.95	2.65	3.534 (16)	155
C12—H12⋯S1ⁱⁱⁱ	0.95	2.98	3.6624 (19)	129
Symmetry codes: (i) $[-x+1, y+{\script{1\over 2}}, -z+{\script{1\over 2}}]$ ; (ii) $[x, -y+{\script{3\over 2}}, z-{\script{1\over 2}}]$ ; (iii) .

Figure 5
Fragment of the crystal structure of (I)

showing part of an [001] C(7) chain linked by N—H⋯N hydrogen bonds (double dashed lines). Symmetry codes: (i) −x, −y, z − $[{1\over 2}]$ ; (ii) −x, −y, z + $[{1\over 2}]$ .

Figure 6
Fragment of the crystal structure of (II)

showing part of an [001] C(6) chain linked by N—H⋯N hydrogen bonds (double-dashed lines). Symmetry code: (i) 1 − x, 1 − y, z + $[{1\over 2}]$ .

Figure 7
Fragment of the crystal structure of (IV)

showing part of an [010] C(4) chain linked by N—H⋯O hydrogen bonds (double-dashed lines). Symmetry codes: (i) 1 − x, $[{1\over 2}]$ + y, $[{1\over 2}]$ − z; (ii) 1 − x, y − $[{1\over 2}]$ , $[{1\over 2}]$ − z.

The shortest aromatic ring centroid–centroid separations in these structures are π_t⋯π_p (t = thiophene, p = pyridine) = 4.046 (2) Å (slippage = 1.546 Å) for (I), π_t⋯π_p = 4.0509 (12) Å (slippage = 1.929 Å) for (II), π_t⋯π_p = 4.7831 (9) Å for (III) and π_t⋯π_p = 4.643 (2) Å for (IV). Given these distances, any aromatic ring-stacking effects that contribute to the cohesion and stability of the crystal must be weak to non-existent.

In order to gain more insight into these different packing motifs, the Hirshfeld surfaces and fingerprint plots for (I)–(IV) were calculated using CrystalExplorer (Turner et al., 2017 ) following the approach recently described by Tan et al. (2019 ). The Hirshfeld surfaces (see supporting information) show the expected red spots (close contacts) in the vicinities of the various donor and acceptor atoms.

The fingerprint plots for (I)–(IV) decomposed into the different percentage contact types (Table 5) show that the different contributions are broadly similar, with H⋯H (van der Waals) contacts the most significant for each structure, followed by C⋯H/H⋯C. The O⋯H/H⋯O and N⋯H/H⋯N contributions are almost the same for the four structures, despite the lack of classical hydrogen bonds in (III). The S⋯H/H⋯S percentage contributions for (I) and (IV) are notably greater than those for (II) and (III), possibly because the S atom is `facing outwards' in the former structures but is associated with an intramolecular C—H⋯S close contact arising from the pyridine ring in the latter structures. It is notable that the percentage of O⋯O contacts is zero in all structures, presumably reflecting the fact that `bare' O atoms avoid each other in the solid state for electrostatic reasons.

Table 5
Hirshfeld fingerprint contact percentages for (I)–(IV)

Contact type	(I)	(II)	(III)	(IV)^a
H⋯H	30.1	32.8	36.5	34.5
C⋯H/H⋯C	15.1	23.3	28.2	22.6
O⋯H/H⋯O	13.1	12.8	10.4	11.2
N⋯H/H⋯N	13.7	12.2	11.5	13.8
S⋯H/H⋯S	12.1	7.0	5.8	10.7
C⋯C	6.2	4.5	1.8	1.2
C⋯O/O⋯C	1.3	0.8	0.7	1.0
O⋯O	0.0	0.0	0.0	0.0
Note: (a) Major disorder component.

4. Database survey

A survey of the Cambridge Structural Database (CSD Core 2012.3 version of March 2022; Groom et al., 2016 ) revealed nine structures incorporating the T—C(=O)—NH—N=CH—Q (T = thiophene ring; Q = thiophene or furan or pyrrole ring or derivatives) grouping and two with the T—CH₂—C(=O)—NH—N=CH—Q sequence. None of these structures features a pyridine ring in the `Q' position.

5. Synthesis and crystallization

Compounds (I) and (II) were prepared by a literature procedure (Lima et al., 2000) and single crystals suitable for data collection were recrystallized from ethanol solution at room temperature. For the syntheses and spectroscopic characterizations of (III) and (IV), see Cardoso et al. (2016a) and Cardoso et al. (2014), respectively: in each case, colourless blocks suitable for X-ray data collections were recrystallized from ethanol solution at room temperature.

6. Refinement

Crystal data, data collection and structure refinement details are summarized in Table 6. The thiophene ring in (IV) was modelled as disordered over two sets of sites related by an approximate rotation of 180° about the C4—C5 bond in a 0.851 (2): 0.149 (2) ratio. EADP cards in SHELXL were used for the U_ij values of equivalent atom pairs (e.g., C1 and C1B) and a SAME card was used to restrain the nearest-neighbour and next-nearest-neighbour bond distances in the two disorder components to be equal with standard deviations of 0.02 and 0.04 Å, respectively. The N-bound H atoms in (I), (II) and (IV) were located in difference maps and their positions were freely refined with U_iso(H) = 1.2U_eq(N). All C-bound H atoms were located geometrically (C—H = 0.95–0.99 Å) and refined as riding atoms with U_iso(H) = 1.2U_eq(C) or 1.5U_eq(methyl C). The methyl group in (III) was allowed to rotate, but not to tip, to best fit the electron density.

Table 6
Experimental details

	(I)	(II)	(III)	(IV)
Crystal data
Chemical formula	C₁₁H₉N₃OS	C₁₁H₉N₃OS	C₁₂H₁₁N₃OS	C₁₂H₁₁N₃OS
M_r	231.27	231.27	245.30	245.30
Crystal system, space group	Orthorhombic, Pca2₁	Orthorhombic, Pna2₁	Monoclinic, C2/c	Monoclinic, P2₁/c
Temperature (K)	100	100	100	100
a, b, c (Å)	10.6845 (9), 9.4974 (9), 10.0917 (10)	18.4056 (13), 9.5255 (7), 6.0300 (4)	21.0690 (15), 5.1085 (4), 21.1531 (15)	11.3963 (8), 9.2782 (7), 11.8178 (8)
α, β, γ (°)	90, 90, 90	90, 90, 90	90, 95.265 (2), 90	90, 112.761 (2), 90
V (Å³)	1024.05 (16)	1057.19 (13)	2267.1 (3)	1152.27 (14)
Z	4	4	8	4
Radiation type	Mo Kα	Mo Kα	Mo Kα	Mo Kα
μ (mm⁻¹)	0.30	0.29	0.27	0.27
Crystal size (mm)	0.05 × 0.04 × 0.01	0.15 × 0.06 × 0.04	0.42 × 0.12 × 0.03	0.10 × 0.09 × 0.06

Data collection
Diffractometer	Rigaku Saturn724+ CCD	Rigaku Saturn724+ CCD	Rigaku Saturn724+ CCD	Rigaku AFC12 CCD
Absorption correction	Multi-scan (CrystalClear; Rigaku, 2012 )	Multi-scan (CrystalClear; Rigaku, 2012)	Multi-scan (CrystalClear; Rigaku, 2012)	Multi-scan (CrystalClear; Rigaku, 2012)
T_min, T_max	0.484, 1.000	0.756, 1.000	0.780, 1.000	0.723, 1.000
No. of measured, independent and observed [I > 2σ(I)] reflections	6740, 1822, 1559	7314, 1979, 1930	8717, 2563, 2307	8155, 2593, 2138
R_int	0.058	0.026	0.022	0.031
(sin θ/λ)_max (Å⁻¹)	0.649	0.649	0.650	0.670

Refinement
R[F² > 2σ(F²)], wR(F²), S	0.046, 0.112, 1.08	0.029, 0.083, 1.08	0.031, 0.087, 1.07	0.041, 0.112, 1.10
No. of reflections	1822	1979	2563	2593
No. of parameters	148	148	155	170
No. of restraints	1	1	0	10
H-atom treatment	H atoms treated by a mixture of independent and constrained refinement	H atoms treated by a mixture of independent and constrained refinement	H-atom parameters constrained	H atoms treated by a mixture of independent and constrained refinement
Δρ_max, Δρ_min (e Å⁻³)	0.27, −0.43	0.33, −0.24	0.33, −0.29	0.32, −0.30
Absolute structure	Parsons et al. (2013 )	Parsons et al. (2013)	–	–
Absolute structure parameter	0.02 (13)	0.04 (4)	–	–
Computer programs: CrystalClear (Rigaku, 2012), SHELXS97 (Sheldrick, 2008 ), SHELXL2018/3 (Sheldrick, 2015 ), ORTEP-3 for Windows (Farrugia, 2012 ) and publCIF (Westrip, 2010 ).

Supporting information

CCDC references: 2172437; 2172436; 2172435; 2172434

Crystal structure: contains datablocks I, II, III, IV, global. DOI: https://doi.org/10.1107/S2056989022005151/zl5030sup1.cif

Structure factors: contains datablock I. DOI: https://doi.org/10.1107/S2056989022005151/zl5030Isup2.hkl

Structure factors: contains datablock II. DOI: https://doi.org/10.1107/S2056989022005151/zl5030IIsup3.hkl

Structure factors: contains datablock III. DOI: https://doi.org/10.1107/S2056989022005151/zl5030IIIsup4.hkl

Structure factors: contains datablock IV. DOI: https://doi.org/10.1107/S2056989022005151/zl5030IVsup5.hkl

Supporting information file. DOI: https://doi.org/10.1107/S2056989022005151/zl5030Isup6.cml

Supporting information file. DOI: https://doi.org/10.1107/S2056989022005151/zl5030IIsup7.cml

Supporting information file. DOI: https://doi.org/10.1107/S2056989022005151/zl5030IIIsup8.cml

Supporting information file. DOI: https://doi.org/10.1107/S2056989022005151/zl5030IVsup9.cml

Hirshfeld surfaces. DOI: https://doi.org/10.1107/S2056989022005151/zl5030sup10.docx

checkCIF report

Computing details top

For all structures, data collection: CrystalClear (Rigaku, 2012); cell refinement: CrystalClear (Rigaku, 2012); data reduction: CrystalClear (Rigaku, 2012); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL2018/3 (Sheldrick, 2015); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); software used to prepare material for publication: publCIF (Westrip, 2010).

N'-[(E)-Pyridin-3-ylmethylidene]thiophene-2-carbohydrazide (I) top

Crystal data top

C₁₁H₉N₃OS	D_x = 1.500 Mg m⁻³
M_r = 231.27	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, Pca2₁	Cell parameters from 5861 reflections
a = 10.6845 (9) Å	θ = 3.5–27.5°
b = 9.4974 (9) Å	µ = 0.30 mm⁻¹
c = 10.0917 (10) Å	T = 100 K
V = 1024.05 (16) Å³	Chip, colourless
Z = 4	0.05 × 0.04 × 0.01 mm
F(000) = 480

Data collection top

Rigaku Saturn724+ CCD diffractometer	1559 reflections with I > 2σ(I)
ω scans	R_int = 0.058
Absorption correction: multi-scan (CrystalClear; Rigaku, 2012)	θ_max = 27.5°, θ_min = 3.5°
T_min = 0.484, T_max = 1.000	h = −12→13
6740 measured reflections	k = −12→12
1822 independent reflections	l = −7→13

Refinement top

Refinement on F²	Hydrogen site location: mixed
Least-squares matrix: full	H atoms treated by a mixture of independent and constrained refinement
R[F² > 2σ(F²)] = 0.046	w = 1/[σ²(F_o²) + (0.0492P)² + 0.5837P] where P = (F_o² + 2F_c²)/3
wR(F²) = 0.112	(Δ/σ)_max < 0.001
S = 1.08	Δρ_max = 0.27 e Å⁻³
1822 reflections	Δρ_min = −0.43 e Å⁻³
148 parameters	Absolute structure: Parsons et al. (2013)
1 restraint	Absolute structure parameter: 0.02 (13)
Primary atom site location: structure-invariant direct methods

Special details top

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
C1	0.4074 (4)	0.5100 (5)	−0.3833 (5)	0.0253 (10)
H1	0.444915	0.579791	−0.437808	0.030*
C2	0.2866 (4)	0.4653 (4)	−0.3959 (5)	0.0239 (10)
H2	0.230294	0.500393	−0.460776	0.029*
C3	0.2544 (4)	0.3608 (4)	−0.3018 (5)	0.0236 (10)
H3	0.173924	0.318696	−0.296656	0.028*
C4	0.3510 (4)	0.3271 (4)	−0.2195 (4)	0.0199 (10)
C5	0.3644 (4)	0.2257 (4)	−0.1092 (4)	0.0194 (9)
C6	0.1581 (4)	0.0118 (5)	0.0671 (5)	0.0215 (9)
H6	0.084911	0.035530	0.018411	0.026*
C7	0.1483 (4)	−0.0844 (4)	0.1798 (4)	0.0188 (9)
C8	0.2501 (3)	−0.1470 (4)	0.2449 (6)	0.0215 (9)
H8	0.333133	−0.132248	0.214145	0.026*
C9	0.2277 (4)	−0.2306 (4)	0.3544 (5)	0.0208 (9)
H9	0.295199	−0.273712	0.400284	0.025*
C10	0.1052 (4)	−0.2507 (5)	0.3966 (5)	0.0228 (10)
H10	0.091113	−0.306383	0.473419	0.027*
C11	0.0286 (3)	−0.1154 (4)	0.2275 (5)	0.0196 (9)
H11	−0.041192	−0.077506	0.181272	0.023*
N1	0.2581 (3)	0.1569 (4)	−0.0731 (4)	0.0196 (8)
H1N	0.186 (4)	0.181 (5)	−0.107 (5)	0.023*
N2	0.2634 (3)	0.0646 (4)	0.0328 (4)	0.0211 (8)
N3	0.0061 (3)	−0.1955 (4)	0.3344 (4)	0.0217 (8)
O1	0.4666 (3)	0.2073 (3)	−0.0557 (4)	0.0278 (8)
S1	0.48271 (9)	0.42487 (11)	−0.25732 (14)	0.0248 (3)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.030 (2)	0.024 (2)	0.022 (3)	−0.0009 (18)	0.009 (2)	0.002 (2)
C2	0.030 (2)	0.026 (2)	0.016 (3)	0.0038 (18)	0.000 (2)	0.006 (2)
C3	0.026 (2)	0.022 (2)	0.022 (3)	0.0033 (16)	−0.0001 (18)	0.0045 (19)
C4	0.025 (2)	0.0204 (19)	0.015 (2)	0.0014 (16)	−0.0012 (18)	−0.0021 (17)
C5	0.020 (2)	0.022 (2)	0.017 (2)	−0.0029 (16)	0.0016 (18)	−0.0019 (19)
C6	0.0196 (19)	0.025 (2)	0.019 (2)	−0.0002 (17)	−0.004 (2)	−0.0007 (19)
C7	0.018 (2)	0.0216 (19)	0.017 (2)	−0.0014 (15)	0.0001 (18)	−0.0027 (18)
C8	0.0177 (18)	0.0242 (19)	0.023 (2)	−0.0026 (13)	−0.002 (3)	−0.005 (2)
C9	0.020 (2)	0.026 (2)	0.017 (2)	0.0002 (16)	−0.006 (2)	0.001 (2)
C10	0.025 (2)	0.027 (2)	0.017 (2)	0.0016 (17)	−0.001 (2)	−0.0001 (19)
C11	0.0169 (17)	0.0238 (18)	0.018 (2)	0.0012 (14)	−0.001 (2)	−0.002 (2)
N1	0.0164 (17)	0.0258 (18)	0.016 (2)	−0.0001 (14)	−0.0040 (16)	0.0038 (16)
N2	0.0247 (19)	0.0223 (18)	0.016 (2)	−0.0014 (14)	−0.0010 (18)	0.0000 (16)
N3	0.0250 (18)	0.0222 (16)	0.018 (2)	0.0005 (15)	0.0031 (17)	−0.0009 (16)
O1	0.0179 (15)	0.0385 (18)	0.0270 (19)	−0.0039 (12)	−0.0050 (15)	0.0063 (17)
S1	0.0222 (5)	0.0301 (5)	0.0221 (6)	−0.0036 (4)	0.0015 (6)	0.0037 (6)

Geometric parameters (Å, º) top

C1—C2	1.364 (6)	C6—H6	0.9500
C1—S1	1.708 (5)	C7—C11	1.398 (5)
C1—H1	0.9500	C7—C8	1.403 (6)
C2—C3	1.415 (6)	C8—C9	1.381 (7)
C2—H2	0.9500	C8—H8	0.9500
C3—C4	1.363 (6)	C9—C10	1.390 (6)
C3—H3	0.9500	C9—H9	0.9500
C4—C5	1.479 (6)	C10—N3	1.338 (5)
C4—S1	1.729 (4)	C10—H10	0.9500
C5—O1	1.230 (5)	C11—N3	1.342 (6)
C5—N1	1.360 (5)	C11—H11	0.9500
C6—N2	1.280 (5)	N1—N2	1.384 (5)
C6—C7	1.463 (6)	N1—H1N	0.87 (5)

C2—C1—S1	111.6 (3)	C8—C7—C6	125.0 (4)
C2—C1—H1	124.2	C9—C8—C7	118.9 (4)
S1—C1—H1	124.2	C9—C8—H8	120.5
C1—C2—C3	112.7 (4)	C7—C8—H8	120.5
C1—C2—H2	123.7	C8—C9—C10	119.2 (4)
C3—C2—H2	123.7	C8—C9—H9	120.4
C4—C3—C2	112.9 (4)	C10—C9—H9	120.4
C4—C3—H3	123.5	N3—C10—C9	123.2 (4)
C2—C3—H3	123.5	N3—C10—H10	118.4
C3—C4—C5	133.3 (4)	C9—C10—H10	118.4
C3—C4—S1	110.8 (3)	N3—C11—C7	124.1 (4)
C5—C4—S1	115.9 (3)	N3—C11—H11	118.0
O1—C5—N1	123.7 (4)	C7—C11—H11	118.0
O1—C5—C4	120.6 (4)	C5—N1—N2	118.5 (4)
N1—C5—C4	115.7 (4)	C5—N1—H1N	120 (3)
N2—C6—C7	121.1 (4)	N2—N1—H1N	120 (3)
N2—C6—H6	119.4	C6—N2—N1	114.8 (4)
C7—C6—H6	119.4	C10—N3—C11	117.3 (4)
C11—C7—C8	117.3 (4)	C1—S1—C4	92.0 (2)
C11—C7—C6	117.7 (4)

S1—C1—C2—C3	0.2 (5)	C8—C9—C10—N3	1.6 (7)
C1—C2—C3—C4	−0.3 (6)	C8—C7—C11—N3	3.2 (6)
C2—C3—C4—C5	−179.1 (5)	C6—C7—C11—N3	−176.2 (4)
C2—C3—C4—S1	0.2 (5)	O1—C5—N1—N2	2.4 (6)
C3—C4—C5—O1	174.4 (5)	C4—C5—N1—N2	−177.6 (3)
S1—C4—C5—O1	−4.9 (6)	C7—C6—N2—N1	−178.2 (4)
C3—C4—C5—N1	−5.6 (7)	C5—N1—N2—C6	175.1 (4)
S1—C4—C5—N1	175.1 (3)	C9—C10—N3—C11	−1.0 (6)
N2—C6—C7—C11	167.6 (4)	C7—C11—N3—C10	−1.5 (6)
N2—C6—C7—C8	−11.8 (7)	C2—C1—S1—C4	−0.1 (4)
C11—C7—C8—C9	−2.5 (6)	C3—C4—S1—C1	−0.1 (4)
C6—C7—C8—C9	176.9 (4)	C5—C4—S1—C1	179.4 (3)
C7—C8—C9—C10	0.3 (6)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1N···N3ⁱ	0.87 (5)	2.14 (5)	2.995 (5)	166 (4)
C1—H1···O1ⁱⁱ	0.95	2.53	3.471 (6)	171
C3—H3···N3ⁱ	0.95	2.61	3.479 (6)	152
C6—H6···N3ⁱ	0.95	2.59	3.410 (6)	145
C9—H9···O1ⁱⁱⁱ	0.95	2.66	3.397 (5)	135
C11—H11···N2^iv	0.95	2.57	3.481 (6)	160

Symmetry codes: (i) −x, −y, z−1/2; (ii) −x+1, −y+1, z−1/2; (iii) −x+1, −y, z+1/2; (iv) x−1/2, −y, z.

N'-[(E)-Pyridin-2-ylmethylidene]thiophene-2-carbohydrazide (II) top

Crystal data top

C₁₁H₉N₃OS	D_x = 1.453 Mg m⁻³
M_r = 231.27	Mo Kα radiation, λ = 0.71073 Å
Orthorhombic, Pna2₁	Cell parameters from 6000 reflections
a = 18.4056 (13) Å	θ = 2.4–27.5°
b = 9.5255 (7) Å	µ = 0.29 mm⁻¹
c = 6.0300 (4) Å	T = 100 K
V = 1057.19 (13) Å³	Blade, dark orange
Z = 4	0.15 × 0.06 × 0.04 mm
F(000) = 480

Data collection top

Rigaku Saturn724+ CCD diffractometer	1930 reflections with I > 2σ(I)
ω scans	R_int = 0.026
Absorption correction: multi-scan (CrystalClear; Rigaku, 2012)	θ_max = 27.5°, θ_min = 3.1°
T_min = 0.756, T_max = 1.000	h = −23→23
7314 measured reflections	k = −9→12
1979 independent reflections	l = −5→7

Refinement top

Refinement on F²	Hydrogen site location: mixed
Least-squares matrix: full	H atoms treated by a mixture of independent and constrained refinement
R[F² > 2σ(F²)] = 0.029	w = 1/[σ²(F_o²) + (0.0573P)² + 0.2224P] where P = (F_o² + 2F_c²)/3
wR(F²) = 0.083	(Δ/σ)_max = 0.001
S = 1.08	Δρ_max = 0.33 e Å⁻³
1979 reflections	Δρ_min = −0.24 e Å⁻³
148 parameters	Absolute structure: Parsons et al. (2013)
1 restraint	Absolute structure parameter: 0.04 (4)
Primary atom site location: structure-invariant direct methods

Special details top

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
C1	0.80728 (12)	0.2567 (2)	0.9079 (4)	0.0243 (5)
H1	0.844507	0.190518	0.876806	0.029*
C2	0.80182 (12)	0.3272 (2)	1.1043 (4)	0.0240 (5)
H2	0.834112	0.312980	1.225101	0.029*
C3	0.74255 (10)	0.4248 (2)	1.1102 (5)	0.0225 (5)
H3	0.730933	0.483815	1.232138	0.027*
C4	0.70395 (11)	0.4200 (2)	0.9075 (4)	0.0198 (4)
C5	0.64198 (11)	0.5159 (2)	0.8639 (4)	0.0201 (4)
C6	0.56443 (11)	0.3875 (2)	0.3737 (4)	0.0214 (4)
H6	0.530355	0.461814	0.358627	0.026*
C7	0.56402 (10)	0.2730 (2)	0.2119 (5)	0.0207 (4)
C8	0.61299 (11)	0.1601 (2)	0.2192 (5)	0.0248 (4)
H8	0.647838	0.152750	0.334814	0.030*
C9	0.60922 (12)	0.0599 (2)	0.0540 (5)	0.0282 (5)
H9	0.642008	−0.017145	0.053144	0.034*
C10	0.55693 (12)	0.0730 (2)	−0.1110 (5)	0.0276 (5)
H10	0.553393	0.005274	−0.226127	0.033*
C11	0.51001 (12)	0.1869 (2)	−0.1042 (5)	0.0252 (5)
H11	0.474376	0.195559	−0.217400	0.030*
N1	0.60295 (9)	0.50362 (19)	0.6733 (3)	0.0207 (4)
H1N	0.5663 (14)	0.573 (3)	0.629 (5)	0.025*
N2	0.60975 (9)	0.38992 (19)	0.5354 (3)	0.0200 (4)
N3	0.51261 (10)	0.2853 (2)	0.0546 (4)	0.0222 (4)
O1	0.62639 (9)	0.60967 (18)	0.9963 (3)	0.0263 (4)
S1	0.74058 (3)	0.29964 (5)	0.72453 (13)	0.02379 (16)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.0204 (9)	0.0272 (11)	0.0252 (13)	0.0009 (8)	−0.0035 (9)	−0.0004 (11)
C2	0.0236 (10)	0.0273 (10)	0.0209 (12)	−0.0006 (9)	−0.0040 (9)	−0.0004 (10)
C3	0.0180 (9)	0.0194 (9)	0.0302 (14)	0.0013 (7)	0.0020 (9)	0.0050 (10)
C4	0.0203 (8)	0.0214 (9)	0.0177 (11)	−0.0019 (7)	0.0025 (8)	0.0003 (9)
C5	0.0201 (9)	0.0217 (9)	0.0184 (11)	−0.0016 (7)	0.0022 (8)	0.0005 (9)
C6	0.0180 (8)	0.0250 (10)	0.0213 (11)	0.0017 (7)	−0.0001 (9)	−0.0007 (9)
C7	0.0177 (8)	0.0244 (10)	0.0200 (11)	−0.0014 (7)	−0.0005 (10)	0.0021 (11)
C8	0.0205 (9)	0.0279 (10)	0.0258 (12)	0.0017 (7)	−0.0027 (10)	0.0002 (12)
C9	0.0268 (10)	0.0272 (11)	0.0307 (14)	0.0061 (9)	0.0010 (10)	−0.0019 (11)
C10	0.0275 (10)	0.0281 (11)	0.0271 (14)	−0.0002 (9)	0.0022 (10)	−0.0066 (10)
C11	0.0221 (9)	0.0306 (11)	0.0229 (13)	0.0000 (8)	−0.0032 (10)	−0.0009 (10)
N1	0.0199 (8)	0.0231 (8)	0.0189 (11)	0.0017 (7)	0.0003 (7)	−0.0012 (8)
N2	0.0181 (7)	0.0239 (8)	0.0178 (9)	−0.0005 (6)	0.0010 (7)	0.0006 (8)
N3	0.0202 (8)	0.0262 (9)	0.0203 (11)	0.0011 (6)	−0.0014 (8)	−0.0003 (8)
O1	0.0283 (8)	0.0284 (8)	0.0222 (10)	0.0038 (6)	−0.0002 (7)	−0.0046 (7)
S1	0.0226 (2)	0.0288 (3)	0.0200 (3)	0.00348 (18)	−0.0016 (3)	−0.0026 (3)

Geometric parameters (Å, º) top

C1—C2	1.365 (4)	C6—H6	0.9500
C1—S1	1.702 (2)	C7—N3	1.345 (3)
C1—H1	0.9500	C7—C8	1.404 (3)
C2—C3	1.434 (3)	C8—C9	1.381 (4)
C2—H2	0.9500	C8—H8	0.9500
C3—C4	1.415 (3)	C9—C10	1.390 (4)
C3—H3	0.9500	C9—H9	0.9500
C4—C5	1.485 (3)	C10—C11	1.387 (3)
C4—S1	1.728 (2)	C10—H10	0.9500
C5—O1	1.232 (3)	C11—N3	1.341 (3)
C5—N1	1.361 (3)	C11—H11	0.9500
C6—N2	1.284 (3)	N1—N2	1.371 (3)
C6—C7	1.463 (3)	N1—H1N	0.98 (3)

C2—C1—S1	113.11 (17)	C8—C7—C6	123.1 (2)
C2—C1—H1	123.4	C9—C8—C7	118.3 (2)
S1—C1—H1	123.4	C9—C8—H8	120.8
C1—C2—C3	113.4 (2)	C7—C8—H8	120.8
C1—C2—H2	123.3	C8—C9—C10	119.3 (2)
C3—C2—H2	123.3	C8—C9—H9	120.4
C4—C3—C2	109.9 (2)	C10—C9—H9	120.4
C4—C3—H3	125.1	C11—C10—C9	118.7 (2)
C2—C3—H3	125.1	C11—C10—H10	120.6
C3—C4—C5	121.3 (2)	C9—C10—H10	120.6
C3—C4—S1	112.16 (16)	N3—C11—C10	123.0 (2)
C5—C4—S1	126.50 (18)	N3—C11—H11	118.5
O1—C5—N1	119.15 (19)	C10—C11—H11	118.5
O1—C5—C4	120.7 (2)	C5—N1—N2	122.15 (18)
N1—C5—C4	120.1 (2)	C5—N1—H1N	122.2 (17)
N2—C6—C7	121.55 (19)	N2—N1—H1N	115.5 (17)
N2—C6—H6	119.2	C6—N2—N1	114.55 (19)
C7—C6—H6	119.2	C11—N3—C7	117.90 (19)
N3—C7—C8	122.7 (2)	C1—S1—C4	91.48 (12)
N3—C7—C6	114.14 (18)

S1—C1—C2—C3	−1.8 (3)	C8—C9—C10—C11	0.0 (4)
C1—C2—C3—C4	1.0 (3)	C9—C10—C11—N3	−0.1 (4)
C2—C3—C4—C5	−176.80 (19)	O1—C5—N1—N2	−169.81 (19)
C2—C3—C4—S1	0.2 (2)	C4—C5—N1—N2	12.0 (3)
C3—C4—C5—O1	5.8 (3)	C7—C6—N2—N1	−179.61 (19)
S1—C4—C5—O1	−170.67 (17)	C5—N1—N2—C6	173.74 (19)
C3—C4—C5—N1	−176.02 (19)	C10—C11—N3—C7	1.0 (3)
S1—C4—C5—N1	7.5 (3)	C8—C7—N3—C11	−1.9 (3)
N2—C6—C7—N3	179.2 (2)	C6—C7—N3—C11	178.0 (2)
N2—C6—C7—C8	−1.0 (4)	C2—C1—S1—C4	1.60 (19)
N3—C7—C8—C9	1.8 (4)	C3—C4—S1—C1	−0.99 (17)
C6—C7—C8—C9	−178.0 (2)	C5—C4—S1—C1	175.80 (19)
C7—C8—C9—C10	−0.8 (4)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1N···N3ⁱ	0.98 (3)	2.03 (3)	3.013 (3)	177 (3)
C1—H1···O1ⁱⁱ	0.95	2.48	3.101 (3)	123
C2—H2···O1ⁱⁱⁱ	0.95	2.64	3.410 (3)	139

Symmetry codes: (i) −x+1, −y+1, z+1/2; (ii) −x+3/2, y−1/2, z−1/2; (iii) −x+3/2, y−1/2, z+1/2.

N-Methyl-N'-[(E)-pyridin-2-ylmethylidene]thiophene-2-carbohydrazide (III) top

Crystal data top

C₁₂H₁₁N₃OS	F(000) = 1024
M_r = 245.30	D_x = 1.437 Mg m⁻³
Monoclinic, C2/c	Mo Kα radiation, λ = 0.71073 Å
a = 21.0690 (15) Å	Cell parameters from 7400 reflections
b = 5.1085 (4) Å	θ = 2.9–27.5°
c = 21.1531 (15) Å	µ = 0.27 mm⁻¹
β = 95.265 (2)°	T = 100 K
V = 2267.1 (3) Å³	Lath, colourless
Z = 8	0.42 × 0.12 × 0.03 mm

Data collection top

Rigaku Saturn724+ CCD diffractometer	2307 reflections with I > 2σ(I)
ω scans	R_int = 0.022
Absorption correction: multi-scan (CrystalClear; Rigaku, 2012)	θ_max = 27.5°, θ_min = 2.9°
T_min = 0.780, T_max = 1.000	h = −27→27
8717 measured reflections	k = −6→6
2563 independent reflections	l = −27→21

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F² > 2σ(F²)] = 0.031	H-atom parameters constrained
wR(F²) = 0.087	w = 1/[σ²(F_o²) + (0.0408P)² + 2.1991P] where P = (F_o² + 2F_c²)/3
S = 1.07	(Δ/σ)_max = 0.001
2563 reflections	Δρ_max = 0.33 e Å⁻³
155 parameters	Δρ_min = −0.29 e Å⁻³
0 restraints

Special details top

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq
C1	0.50199 (7)	0.8774 (3)	0.34463 (7)	0.0262 (3)
H1	0.525890	0.988871	0.319795	0.031*
C2	0.50475 (7)	0.8871 (3)	0.40904 (7)	0.0283 (3)
H2	0.530839	1.006088	0.434266	0.034*
C3	0.46445 (6)	0.7003 (3)	0.43432 (6)	0.0243 (3)
H3	0.460459	0.680014	0.478420	0.029*
C4	0.43135 (6)	0.5499 (3)	0.38752 (6)	0.0196 (3)
C5	0.38600 (6)	0.3464 (3)	0.40503 (6)	0.0206 (3)
C6	0.30541 (6)	0.0098 (3)	0.37672 (6)	0.0229 (3)
H6A	0.306676	0.001379	0.423104	0.034*
H6B	0.316415	−0.161776	0.360136	0.034*
H6C	0.262463	0.059115	0.359010	0.034*
C7	0.32615 (6)	0.1249 (3)	0.25363 (6)	0.0190 (3)
H7	0.298098	−0.007769	0.265792	0.023*
C8	0.33189 (6)	0.1729 (2)	0.18583 (6)	0.0178 (3)
C9	0.36845 (6)	0.3762 (3)	0.16384 (6)	0.0197 (3)
H9	0.392055	0.489970	0.192720	0.024*
C10	0.36941 (6)	0.4078 (3)	0.09876 (6)	0.0222 (3)
H10	0.393440	0.545017	0.082220	0.027*
C11	0.33481 (7)	0.2364 (3)	0.05837 (6)	0.0247 (3)
H11	0.334717	0.253470	0.013642	0.030*
C12	0.30036 (7)	0.0398 (3)	0.08438 (6)	0.0266 (3)
H12	0.277110	−0.078189	0.056315	0.032*
N1	0.35096 (5)	0.2040 (2)	0.35878 (5)	0.0194 (2)
N2	0.35836 (5)	0.2591 (2)	0.29655 (5)	0.0176 (2)
N3	0.29791 (6)	0.0063 (2)	0.14694 (5)	0.0234 (3)
O1	0.37945 (5)	0.3068 (2)	0.46105 (4)	0.0291 (2)
S1	0.45075 (2)	0.64215 (7)	0.31337 (2)	0.02308 (11)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.0201 (7)	0.0236 (7)	0.0350 (8)	−0.0028 (6)	0.0027 (5)	−0.0049 (6)
C2	0.0219 (7)	0.0273 (7)	0.0349 (8)	0.0015 (6)	−0.0020 (6)	−0.0129 (6)
C3	0.0227 (7)	0.0279 (7)	0.0223 (6)	0.0052 (6)	0.0015 (5)	−0.0055 (5)
C4	0.0183 (6)	0.0220 (6)	0.0185 (6)	0.0042 (5)	0.0015 (5)	−0.0022 (5)
C5	0.0210 (6)	0.0229 (6)	0.0180 (6)	0.0061 (5)	0.0026 (5)	−0.0006 (5)
C6	0.0203 (6)	0.0253 (7)	0.0234 (6)	−0.0005 (6)	0.0038 (5)	0.0070 (5)
C7	0.0185 (6)	0.0182 (6)	0.0204 (6)	0.0001 (5)	0.0031 (5)	0.0018 (5)
C8	0.0167 (6)	0.0178 (6)	0.0188 (6)	0.0023 (5)	0.0010 (4)	−0.0002 (5)
C9	0.0181 (6)	0.0218 (6)	0.0191 (6)	−0.0008 (5)	0.0010 (5)	−0.0009 (5)
C10	0.0216 (6)	0.0239 (7)	0.0218 (6)	−0.0010 (5)	0.0049 (5)	0.0010 (5)
C11	0.0293 (7)	0.0281 (7)	0.0171 (6)	0.0017 (6)	0.0042 (5)	−0.0019 (5)
C12	0.0335 (8)	0.0240 (7)	0.0218 (6)	−0.0036 (6)	0.0006 (5)	−0.0061 (5)
N1	0.0189 (5)	0.0237 (6)	0.0158 (5)	−0.0006 (4)	0.0024 (4)	0.0035 (4)
N2	0.0175 (5)	0.0200 (5)	0.0155 (5)	0.0018 (4)	0.0024 (4)	0.0020 (4)
N3	0.0281 (6)	0.0200 (6)	0.0218 (5)	−0.0030 (5)	0.0008 (4)	−0.0022 (4)
O1	0.0378 (6)	0.0339 (6)	0.0161 (4)	0.0009 (5)	0.0051 (4)	0.0002 (4)
S1	0.02249 (19)	0.02627 (19)	0.02056 (18)	−0.00532 (13)	0.00245 (12)	−0.00153 (12)

Geometric parameters (Å, º) top

C1—C2	1.359 (2)	C7—N2	1.2815 (17)
C1—S1	1.7075 (14)	C7—C8	1.4709 (17)
C1—H1	0.9500	C7—H7	0.9500
C2—C3	1.414 (2)	C8—N3	1.3436 (17)
C2—H2	0.9500	C8—C9	1.3981 (18)
C3—C4	1.3894 (19)	C9—C10	1.3879 (18)
C3—H3	0.9500	C9—H9	0.9500
C4—C5	1.4817 (19)	C10—C11	1.3835 (19)
C4—S1	1.7223 (13)	C10—H10	0.9500
C5—O1	1.2225 (16)	C11—C12	1.382 (2)
C5—N1	1.3780 (17)	C11—H11	0.9500
C6—N1	1.4545 (17)	C12—N3	1.3400 (17)
C6—H6A	0.9800	C12—H12	0.9500
C6—H6B	0.9800	N1—N2	1.3690 (14)
C6—H6C	0.9800

C2—C1—S1	112.41 (11)	C8—C7—H7	119.5
C2—C1—H1	123.8	N3—C8—C9	123.07 (11)
S1—C1—H1	123.8	N3—C8—C7	113.86 (11)
C1—C2—C3	112.48 (13)	C9—C8—C7	123.06 (11)
C1—C2—H2	123.8	C10—C9—C8	118.36 (12)
C3—C2—H2	123.8	C10—C9—H9	120.8
C4—C3—C2	112.53 (12)	C8—C9—H9	120.8
C4—C3—H3	123.7	C11—C10—C9	118.95 (13)
C2—C3—H3	123.7	C11—C10—H10	120.5
C3—C4—C5	120.19 (12)	C9—C10—H10	120.5
C3—C4—S1	110.61 (10)	C12—C11—C10	118.69 (12)
C5—C4—S1	129.19 (10)	C12—C11—H11	120.7
O1—C5—N1	120.00 (13)	C10—C11—H11	120.7
O1—C5—C4	119.42 (12)	N3—C12—C11	123.71 (13)
N1—C5—C4	120.58 (11)	N3—C12—H12	118.1
N1—C6—H6A	109.5	C11—C12—H12	118.1
N1—C6—H6B	109.5	N2—N1—C5	118.24 (11)
H6A—C6—H6B	109.5	N2—N1—C6	121.81 (11)
N1—C6—H6C	109.5	C5—N1—C6	119.89 (11)
H6A—C6—H6C	109.5	C7—N2—N1	118.14 (11)
H6B—C6—H6C	109.5	C12—N3—C8	117.20 (12)
N2—C7—C8	121.06 (12)	C1—S1—C4	91.97 (7)
N2—C7—H7	119.5

S1—C1—C2—C3	−0.08 (16)	C10—C11—C12—N3	0.7 (2)
C1—C2—C3—C4	0.02 (18)	O1—C5—N1—N2	178.23 (11)
C2—C3—C4—C5	−179.06 (12)	C4—C5—N1—N2	−1.19 (18)
C2—C3—C4—S1	0.04 (15)	O1—C5—N1—C6	1.06 (19)
C3—C4—C5—O1	−2.21 (19)	C4—C5—N1—C6	−178.37 (11)
S1—C4—C5—O1	178.88 (10)	C8—C7—N2—N1	−179.79 (11)
C3—C4—C5—N1	177.22 (12)	C5—N1—N2—C7	179.40 (12)
S1—C4—C5—N1	−1.69 (19)	C6—N1—N2—C7	−3.49 (18)
N2—C7—C8—N3	176.35 (12)	C11—C12—N3—C8	−1.0 (2)
N2—C7—C8—C9	−4.8 (2)	C9—C8—N3—C12	0.5 (2)
N3—C8—C9—C10	0.3 (2)	C7—C8—N3—C12	179.38 (12)
C7—C8—C9—C10	−178.51 (12)	C2—C1—S1—C4	0.09 (12)
C8—C9—C10—C11	−0.6 (2)	C3—C4—S1—C1	−0.07 (11)
C9—C10—C11—C12	0.1 (2)	C5—C4—S1—C1	178.92 (13)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
C9—H9···S1	0.95	2.84	3.7217 (13)	155
C6—H6C···N3ⁱ	0.98	2.61	3.3499 (18)	132

Symmetry code: (i) −x+1/2, y+1/2, −z+1/2.

N'-[(E)-Pyridin-2-ylmethylidene]-2-(thiophen-2-yl)ethanohydrazide (IV) top

Crystal data top

C₁₂H₁₁N₃OS	F(000) = 512
M_r = 245.30	D_x = 1.414 Mg m⁻³
Monoclinic, P2₁/c	Mo Kα radiation, λ = 0.71073 Å
a = 11.3963 (8) Å	Cell parameters from 43879 reflections
b = 9.2782 (7) Å	θ = 2.9–27.5°
c = 11.8178 (8) Å	µ = 0.27 mm⁻¹
β = 112.761 (2)°	T = 100 K
V = 1152.27 (14) Å³	Block, colourless
Z = 4	0.10 × 0.09 × 0.06 mm

Data collection top

Rigaku AFC12 CCD diffractometer	2138 reflections with I > 2σ(I)
ω scans	R_int = 0.031
Absorption correction: multi-scan (CrystalClear; Rigaku, 2012)	θ_max = 28.4°, θ_min = 2.9°
T_min = 0.723, T_max = 1.000	h = −15→14
8155 measured reflections	k = −12→11
2593 independent reflections	l = −14→14

Refinement top

Refinement on F²	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Hydrogen site location: mixed
R[F² > 2σ(F²)] = 0.041	H atoms treated by a mixture of independent and constrained refinement
wR(F²) = 0.112	w = 1/[σ²(F_o²) + (0.0505P)² + 0.7045P] where P = (F_o² + 2F_c²)/3
S = 1.10	(Δ/σ)_max < 0.001
2593 reflections	Δρ_max = 0.32 e Å⁻³
170 parameters	Δρ_min = −0.30 e Å⁻³
10 restraints

Special details top

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å²) top

	x	y	z	U_iso*/U_eq	Occ. (<1)
C1	0.9466 (2)	0.7136 (3)	0.2749 (2)	0.0222 (5)	0.851 (2)
H1	1.033688	0.689483	0.317920	0.027*	0.851 (2)
C2	0.8750 (2)	0.6617 (3)	0.1571 (2)	0.0203 (5)	0.851 (2)
H2	0.905946	0.598307	0.111806	0.024*	0.851 (2)
C3	0.7527 (8)	0.7158 (11)	0.1161 (7)	0.0246 (10)	0.851 (2)
H3	0.689801	0.695835	0.037087	0.029*	0.851 (2)
C4	0.73066 (15)	0.80326 (17)	0.20255 (15)	0.0211 (3)	0.851 (2)
S1	0.86521 (5)	0.82422 (7)	0.33564 (5)	0.02360 (18)	0.851 (2)
C1B	0.8982 (14)	0.684 (2)	0.1833 (17)	0.0203 (5)	0.149 (2)
H1B	0.956589	0.632055	0.158977	0.024*	0.149 (2)
C2B	0.9327 (13)	0.7537 (17)	0.2944 (14)	0.0222 (5)	0.149 (2)
H2B	1.015819	0.750408	0.356806	0.027*	0.149 (2)
C3B	0.8327 (13)	0.829 (2)	0.3049 (14)	0.02360 (18)	0.149 (2)
H3B	0.836035	0.888345	0.371821	0.028*	0.149 (2)
C4B	0.73066 (15)	0.80326 (17)	0.20255 (15)	0.0211 (3)	0.149 (2)
S1B	0.7385 (12)	0.6996 (17)	0.0929 (12)	0.0246 (10)	0.149 (2)
C5	0.61018 (15)	0.86577 (18)	0.19459 (16)	0.0231 (3)
H5A	0.553207	0.878920	0.107425	0.028*
H5B	0.625573	0.961417	0.234861	0.028*
C6	0.54702 (14)	0.76587 (17)	0.25759 (15)	0.0206 (3)
C7	0.35889 (15)	0.83579 (18)	0.42527 (15)	0.0223 (3)
H7	0.359384	0.937962	0.420223	0.027*
C8	0.28771 (14)	0.76417 (18)	0.49016 (15)	0.0207 (3)
C9	0.27577 (15)	0.61405 (19)	0.49162 (16)	0.0243 (4)
H9	0.314773	0.554343	0.450832	0.029*
C10	0.20629 (15)	0.55382 (19)	0.55336 (16)	0.0271 (4)
H10	0.197174	0.452251	0.556146	0.033*
C11	0.14999 (16)	0.64555 (19)	0.61139 (16)	0.0260 (4)
H11	0.101007	0.607862	0.653853	0.031*
C12	0.16714 (16)	0.79323 (19)	0.60568 (17)	0.0267 (4)
H12	0.129255	0.854810	0.646226	0.032*
N1	0.48282 (13)	0.83765 (15)	0.31638 (13)	0.0211 (3)
H1N	0.4714 (18)	0.932 (2)	0.3080 (18)	0.025*
N2	0.42014 (12)	0.76009 (15)	0.37563 (13)	0.0213 (3)
N3	0.23384 (13)	0.85429 (16)	0.54651 (13)	0.0247 (3)
O1	0.55355 (11)	0.63460 (13)	0.25449 (13)	0.0280 (3)

Atomic displacement parameters (Å²) top

	U¹¹	U²²	U³³	U¹²	U¹³	U²³
C1	0.0172 (8)	0.0271 (13)	0.0254 (12)	0.0030 (8)	0.0118 (7)	0.0006 (9)
C2	0.0203 (11)	0.0209 (13)	0.0221 (14)	−0.0002 (9)	0.0109 (10)	−0.0036 (8)
C3	0.0205 (18)	0.024 (2)	0.028 (3)	−0.0032 (14)	0.0080 (19)	−0.0029 (17)
C4	0.0196 (7)	0.0194 (7)	0.0245 (8)	−0.0023 (6)	0.0088 (6)	0.0032 (6)
S1	0.0191 (3)	0.0280 (3)	0.0230 (3)	−0.0014 (2)	0.0073 (2)	−0.0037 (2)
C1B	0.0203 (11)	0.0209 (13)	0.0221 (14)	−0.0002 (9)	0.0109 (10)	−0.0036 (8)
C2B	0.0172 (8)	0.0271 (13)	0.0254 (12)	0.0030 (8)	0.0118 (7)	0.0006 (9)
C3B	0.0191 (3)	0.0280 (3)	0.0230 (3)	−0.0014 (2)	0.0073 (2)	−0.0037 (2)
C4B	0.0196 (7)	0.0194 (7)	0.0245 (8)	−0.0023 (6)	0.0088 (6)	0.0032 (6)
S1B	0.0205 (18)	0.024 (2)	0.028 (3)	−0.0032 (14)	0.0080 (19)	−0.0029 (17)
C5	0.0204 (7)	0.0176 (7)	0.0319 (9)	−0.0002 (6)	0.0108 (6)	0.0024 (7)
C6	0.0164 (6)	0.0194 (8)	0.0244 (8)	−0.0001 (6)	0.0061 (6)	0.0011 (6)
C7	0.0219 (7)	0.0192 (8)	0.0251 (8)	0.0000 (6)	0.0083 (6)	0.0006 (6)
C8	0.0181 (7)	0.0218 (8)	0.0211 (8)	0.0005 (6)	0.0064 (6)	−0.0013 (6)
C9	0.0212 (7)	0.0231 (8)	0.0298 (9)	0.0009 (6)	0.0112 (6)	−0.0033 (7)
C10	0.0224 (7)	0.0222 (8)	0.0354 (10)	−0.0002 (6)	0.0098 (7)	0.0021 (7)
C11	0.0239 (7)	0.0267 (9)	0.0286 (9)	−0.0009 (6)	0.0114 (7)	0.0032 (7)
C12	0.0273 (8)	0.0277 (9)	0.0300 (9)	0.0014 (7)	0.0163 (7)	−0.0025 (7)
N1	0.0213 (6)	0.0168 (6)	0.0271 (7)	0.0006 (5)	0.0114 (6)	0.0015 (5)
N2	0.0183 (6)	0.0211 (7)	0.0244 (7)	−0.0007 (5)	0.0081 (5)	0.0013 (5)
N3	0.0247 (6)	0.0225 (7)	0.0290 (8)	0.0012 (5)	0.0128 (6)	−0.0003 (6)
O1	0.0267 (6)	0.0161 (6)	0.0475 (8)	−0.0002 (5)	0.0214 (6)	0.0000 (5)

Geometric parameters (Å, º) top

C1—C2	1.399 (3)	C5—H5A	0.9900
C1—S1	1.716 (2)	C5—H5B	0.9900
C1—H1	0.9500	C6—O1	1.222 (2)
C2—C3	1.380 (8)	C6—N1	1.362 (2)
C2—H2	0.9500	C7—N2	1.281 (2)
C3—C4	1.401 (7)	C7—C8	1.473 (2)
C3—H3	0.9500	C7—H7	0.9500
C4—C5	1.460 (2)	C8—N3	1.355 (2)
C4—S1	1.7311 (16)	C8—C9	1.400 (2)
C1B—C2B	1.379 (15)	C9—C10	1.385 (2)
C1B—S1B	1.723 (16)	C9—H9	0.9500
C1B—H1B	0.9500	C10—C11	1.395 (2)
C2B—C3B	1.384 (15)	C10—H10	0.9500
C2B—H2B	0.9500	C11—C12	1.389 (2)
C3B—C4B	1.337 (13)	C11—H11	0.9500
C3B—H3B	0.9500	C12—N3	1.341 (2)
C4B—C5	1.460 (2)	C12—H12	0.9500
C4B—S1B	1.643 (11)	N1—N2	1.3804 (19)
C5—C6	1.532 (2)	N1—H1N	0.88 (2)

C2—C1—S1	114.85 (18)	C4—C5—H5B	109.8
C2—C1—H1	122.6	C6—C5—H5B	109.8
S1—C1—H1	122.6	H5A—C5—H5B	108.2
C3—C2—C1	110.2 (3)	O1—C6—N1	123.63 (15)
C3—C2—H2	124.9	O1—C6—C5	122.90 (15)
C1—C2—H2	124.9	N1—C6—C5	113.47 (14)
C2—C3—C4	113.4 (5)	N2—C7—C8	119.90 (15)
C2—C3—H3	123.3	N2—C7—H7	120.1
C4—C3—H3	123.3	C8—C7—H7	120.1
C3—C4—C5	127.8 (3)	N3—C8—C9	122.90 (15)
C3—C4—S1	112.4 (3)	N3—C8—C7	115.03 (15)
C5—C4—S1	119.63 (13)	C9—C8—C7	122.07 (15)
C1—S1—C4	89.14 (10)	C10—C9—C8	119.07 (16)
C2B—C1B—S1B	113.1 (12)	C10—C9—H9	120.5
C2B—C1B—H1B	123.4	C8—C9—H9	120.5
S1B—C1B—H1B	123.4	C9—C10—C11	118.56 (16)
C1B—C2B—C3B	112.6 (13)	C9—C10—H10	120.7
C1B—C2B—H2B	123.7	C11—C10—H10	120.7
C3B—C2B—H2B	123.7	C12—C11—C10	118.53 (16)
C4B—C3B—C2B	106.5 (12)	C12—C11—H11	120.7
C4B—C3B—H3B	126.7	C10—C11—H11	120.7
C2B—C3B—H3B	126.7	N3—C12—C11	124.09 (16)
C3B—C4B—C5	117.0 (7)	N3—C12—H12	118.0
C3B—C4B—S1B	121.7 (7)	C11—C12—H12	118.0
C5—C4B—S1B	121.2 (4)	C6—N1—N2	119.30 (13)
C4B—S1B—C1B	85.9 (8)	C6—N1—H1N	120.7 (13)
C4B—C5—C6	109.60 (13)	N2—N1—H1N	119.4 (13)
C4—C5—C6	109.60 (13)	C7—N2—N1	115.27 (14)
C4—C5—H5A	109.8	C12—N3—C8	116.84 (15)
C6—C5—H5A	109.8

S1—C1—C2—C3	1.1 (6)	C4B—C5—C6—O1	−35.6 (2)
C1—C2—C3—C4	−2.0 (9)	C4—C5—C6—O1	−35.6 (2)
C2—C3—C4—C5	−173.4 (4)	C4B—C5—C6—N1	144.72 (14)
C2—C3—C4—S1	2.1 (9)	C4—C5—C6—N1	144.72 (14)
C2—C1—S1—C4	0.1 (2)	N2—C7—C8—N3	175.58 (14)
C3—C4—S1—C1	−1.2 (5)	N2—C7—C8—C9	−5.2 (2)
C5—C4—S1—C1	174.74 (15)	N3—C8—C9—C10	−0.2 (2)
S1B—C1B—C2B—C3B	−4 (2)	C7—C8—C9—C10	−179.31 (15)
C1B—C2B—C3B—C4B	3 (2)	C8—C9—C10—C11	0.4 (2)
C2B—C3B—C4B—C5	176.8 (10)	C9—C10—C11—C12	−0.6 (2)
C2B—C3B—C4B—S1B	−0.5 (19)	C10—C11—C12—N3	0.7 (3)
C3B—C4B—S1B—C1B	−1.5 (16)	O1—C6—N1—N2	−0.5 (2)
C5—C4B—S1B—C1B	−178.7 (8)	C5—C6—N1—N2	179.18 (13)
C2B—C1B—S1B—C4B	3.1 (18)	C8—C7—N2—N1	179.54 (13)
C3B—C4B—C5—C6	−84.9 (10)	C6—N1—N2—C7	−177.90 (14)
S1B—C4B—C5—C6	92.4 (7)	C11—C12—N3—C8	−0.5 (3)
C3—C4—C5—C6	93.8 (6)	C9—C8—N3—C12	0.2 (2)
S1—C4—C5—C6	−81.44 (16)	C7—C8—N3—C12	179.39 (14)

Hydrogen-bond geometry (Å, º) top

D—H···A	D—H	H···A	D···A	D—H···A
N1—H1N···O1ⁱ	0.88 (2)	2.00 (2)	2.8628 (18)	164.9 (18)
C3—H3···N1ⁱⁱ	0.95	2.78	3.718 (7)	172
C5—H5B···O1ⁱ	0.99	2.64	3.307 (2)	125
C7—H7···S1Bⁱ	0.95	2.65	3.534 (16)	155
C12—H12···S1ⁱⁱⁱ	0.95	2.98	3.6624 (19)	129

Symmetry codes: (i) −x+1, y+1/2, −z+1/2; (ii) x, −y+3/2, z−1/2; (iii) −x+1, −y+2, −z+1.

Hirshfeld fingerprint contact percentages for (I)–(IV) top

Contact type	(I)	(II)	(III)	(IV)^a
H···H	30.1	32.8	36.5	34.5
C···H/H···C	15.1	23.3	28.2	22.6
O···H/H···O	13.1	12.8	10.4	11.2
N···H/H···N	13.7	12.2	11.5	13.8
S···H/H···S	12.1	7.0	5.8	10.7
C···C	6.2	4.5	1.8	1.2
C···O/O···C	1.3	0.8	0.7	1.0
O···O	0.0	0.0	0.0	0.0

Note: (a) Major disorder component.

Acknowledgements

We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections.

References

Abbas, S., Imtiaz-ud-din, Mehmood, M., Rauf, M. K., Azam, S. S., Ihsan-ul Haq, Tahir, M. N. & Parvaiz, N. (2021). J. Mol. Struct. 1230 article No. 129870. Google Scholar
Cardoso, L. N. F., Bispo, M. L. F., Kaiser, C. R., Wardell, J. L., Wardell, S. M. S. V., Lourenço, M. C. S., Bezerra, F. A. F., Soares, R. P. P., Rocha, M. N. & de Souza, M. V. N. (2014). Arch. Pharm. Chem. Life Sci. 347, 432–448. Web of Science CSD CrossRef CAS Google Scholar
Cardoso, L. N. F., Nogueira, T. C. M., Kaiser, C. R., Wardell, J. L., Wardell, S. M. S. V. & de Souza, M. V. N. (2016a). Mediterr. J. Chem. 5, 356–366. CrossRef CAS Google Scholar
Cardoso, L. N. F., Nogueira, T. C. M., Rodrigues, F. A. R., Oliveira, A. C. A., Luciano, S., Pessoa, C. & de Souza, M. V. N. (2017). Med. Chem. Res. 26, 1605–1608. Web of Science CrossRef CAS Google Scholar
Cardoso, L. N. F., Nogueira, T. C. M., Wardell, J. L., Wardell, S. M. S. V., Souza, M. V. N. de, Jotani, M. M. & Tiekink, E. R. T. (2016c). Acta Cryst. E72, 1025–1031. CSD CrossRef IUCr Journals Google Scholar
Cardoso, L. N. F., Noguiera, T. C. M., Kaiser, C. R., Wardell, J. L., Wardell, S. M. S. V. & de Souza, M. V. N. (2016b). Z. Kristallogr. 231, 167–178. Web of Science CSD CrossRef CAS Google Scholar
Dijken, D. J. van, Kovaříček, P., Ihrig, S. P. & Hecht, S. (2015). J. Am. Chem. Soc. 137, 14982–14991. Web of Science PubMed Google Scholar
Farrugia, L. J. (2012). J. Appl. Cryst. 45, 849–854. Web of Science CrossRef CAS IUCr Journals Google Scholar
Gholivand, K., Farshadfer, K., Roe, M., Gholami, A. & Esrafili, M. D. (2016). CrystEngComm, 18, 2873–2884. Web of Science CSD CrossRef CAS Google Scholar
Ghosh, S., Chopra, P. & Wategaonkar, S. (2020). Phys. Chem. Chem. Phys. 22, 17482–17493. Web of Science CrossRef CAS PubMed Google Scholar
Groom, C. R., Bruno, I. J., Lightfoot, M. P. & Ward, S. C. (2016). Acta Cryst. B72, 171–179. Web of Science CrossRef IUCr Journals Google Scholar
Lima, P. C., Lima, L. M., da Silva, K. C. M., Léda, P. H. O., de Miranda, A. L. P., Fraga, C. A. M. & Barreiro, E. J. (2000). Eur. J. Med. Chem. 35, 187–203. Web of Science CrossRef PubMed CAS Google Scholar
Parsons, S., Flack, H. D. & Wagner, T. (2013). Acta Cryst. B69, 249–259. Web of Science CSD CrossRef CAS IUCr Journals Google Scholar
Rigaku (2012). CrystalClear. Rigaku Corporation, Tokyo, Japan. Google Scholar
Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. Web of Science CrossRef CAS IUCr Journals Google Scholar
Sheldrick, G. M. (2015). Acta Cryst. C71, 3–8. Web of Science CrossRef IUCr Journals Google Scholar
Tan, S. L., Jotani, M. M. & Tiekink, E. R. T. (2019). Acta Cryst. E75, 308–318. Web of Science CrossRef IUCr Journals Google Scholar
Turner, M. J., McKinnon, J. J., Wolff, S. K., Grimwood, D. J., Spackman, P. R., Jayatilaka, D. & Spackman, M. A. (2017). CrystalExplorer17. University of Western Australia, Nedlands, Western Australia; https://hirshfeldsurface.net. Google Scholar
Westrip, S. P. (2010). J. Appl. Cryst. 43, 920–925. Web of Science CrossRef CAS IUCr Journals Google Scholar

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

CRYSTALLOGRAPHIC
COMMUNICATIONS

ISSN: 2056-9890

Volume 78| Part 6| June 2022| Pages 619-624

https://doi.org/10.1107/S2056989022005151

Open

access

Format		BIBTeX
		EndNote
		RefMan
		Refer
		Medline
		CIF
		SGML
		Plain Text
		Text

Format		BIBTeX
		EndNote
		RefMan
		Refer
		Medline
		CIF
		SGML
		Plain Text
		Text

Search IUCr Journals		doi		Advanced search
Author		volume	page

research communications\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\)

Different conformations and packing motifs in the crystal structures of four thio­phene–carbohydrazide–pyridine derivatives

1. Chemical context

2. Structural commentary

3. Supra­molecular features

4. Database survey

5. Synthesis and crystallization

6. Refinement

Supporting information

Acknowledgements

References

research communications

Different conformations and packing motifs in the crystal structures of four thiophene–carbohydrazide–pyridine derivatives

3. Supramolecular features