Figure 4
Stick representation of the GPP-binding site in the Met142/Leu144 mutant MECP synthase structure. An omit (Fo − Fc) difference density map (blue chicken wire) covering GPP and the adjacent water molecules, which are shown as red dots, is contoured at the 1.5σ level. The GPP-binding cavity is lined by Met142 and Leu144 (side-chain C positions colored orange), six phenylalanines (C yellow), aliphatic residues (C pink) and His5 and Glu149, which seal the pit bottom (C white). |