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Figure 4
Stick representation of the GPP-binding site in the Met142/Leu144 mutant MECP synthase structure. An omit (FoFc) difference density map (blue chicken wire) covering GPP and the adjacent water molecules, which are shown as red dots, is contoured at the 1.5σ level. The GPP-binding cavity is lined by Met142 and Leu144 (side-chain C positions colored orange), six phenylalanines (C yellow), aliphatic residues (C pink) and His5 and Glu149, which seal the pit bottom (C white).

ISSN: 2053-230X
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