Figure 2
Factor I cofactors. (a) The crystal structure of the fI cofactor rat CrrY1–4 (PDB entry 2xrb
) as a cartoon representation rainbow coloured from the N-terminus (red) to the C-terminus (blue). (b) Overlay of the crystal structures of CrrY1–4 (PDB entries 2xrb
and 2xrd
; rainbow coloured) on the structure of fH1–4 from the C3b–fH1–4 binary complex (PDB entry 2wii
; Wu et al., 2009; grey). (c) Overlay of CrrY1–4 (blue, this work) and CD461–4 (orange; PDB entry 3o8e
; Persson et al., 2010) on the crystal structure of the complex between fH1–4 and C3b (PDB entry 2wii
). This figure was made using PyMOL (DeLano, 2002). |