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Figure 2
Factor I cofactors. (a) The crystal structure of the fI cofactor rat CrrY1–4 (PDB entry 2xrb ) as a cartoon representation rainbow coloured from the N-terminus (red) to the C-­terminus (blue). (b) Overlay of the crystal structures of CrrY1–4 (PDB entries 2xrb and 2xrd ; rainbow coloured) on the structure of fH1–4 from the C3b–fH1–4 binary complex (PDB entry 2wii ; Wu et al., 2009BB29; grey). (c) Overlay of CrrY1–4 (blue, this work) and CD461–4 (orange; PDB entry 3o8e ; Persson et al., 2010BB16) on the crystal structure of the complex between fH1–4 and C3b (PDB entry 2wii ). This figure was made using PyMOL (DeLano, 2002BB3).

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ISSN: 2053-230X
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