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Figure 3
(a) Superposition of Nas2LND (magenta) with a canonical PDZ domain (PDB entry 1be9 , green). The peptide ligand for 1be9 is shown as blue cylinders. β-Sheet 5 of Nas2LND is indicated. Superposition of a canonical PDZ domain (PDB entry 1be9 ) with Nas2LND was conducted using GESAMT (Krissinel, 2012BB21), which yielded an r.m.s.d. of 2.27 Å for 59 aligned residues. (b) Enlarged view of the β5/α2 region of Nas2LND superimposed with 1be9 . The peptide ligand for 1be9 is shown as a blue ribbon. The GLGF (red) motif of 1be9 and similar residues in front of Nas2LND β-sheet 5, GLLG (black), are indicated. (cf) Superposition of specified regions of PDZ-domain homologs onto Nas2LND colored by secondary structure as in Fig. 1[link]. (c) Nas2LND, (d) PDB entry 3rle (chain A, residues 7–104), (e) PDB entry 3id4 (chain A, residues 223–307), (f) PDB entry 3i1e (chain B, residues 3–85) and (g) PDB entry 3gdv (chain C, residues 279–410).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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