Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor

Wang, F.; Tan, Y.; Li, H.; Chen, X.; Wang, J.; Li, S.; Fu, S.; Zhao, Q.; Chen, C.; Su, D.; Yang, H.

doi:10.1107/S2053230X14012953

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 1
Purification and crystallization of HCoV-NL63 main protease. (a) SDS–PAGE analysis of purified HCoV-NL63 main protease. The molecular masses of the marker and HCoV-NL63 main protease are indicated in kDa. (b) Typical complex crystals of HCoV-NL63 main protease with inhibitor N3 grown by the hanging-drop method. These crystals with typical dimensions of 0.1 × 0.05 × 0.03 mm were used for subsequent diffraction and data collection.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 70| Part 8| July 2014| Pages 1068-1071

doi:10.1107/S2053230X14012953

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