 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 2]](no5061fig2mag.jpg)
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Figure 2
Structure of SDR-WM99c (pink) overlaid with its seven closest structural homologues: 3-oxoacyl-(ACP) reductase (S. aureus FabG1; PDB entry 3sj7 ; cyan), S. enterica dehydrogenase (PDB entry 4g81 ; pale red), 3-oxoacyl-(ACP) reductase (Synechococcus elongatus FabG2; PDB entry 4dmm ; pale green), 3-oxoacyl-(ACP) reductase (S. aureus FabG3; PDB entry 3osu ; pale blue), M. marinum SDR (PDB entry 3r1i ; pale yellow), sorbitol dehydrogenase (Rhodobacter sphaeroides; PDB entry 1k2w ; pale orange) and oestradiol 17-β-dehydrogenase (PDB entry 2pd6 ; blue white). The r.m.s.d. is 1.3–1.5 Å over all Cα atoms. Inset: magnification of the proposed catalytic side chains Asn117, Ser146, Tyr159 and Lys163 indicates close alignment of the active-site residues. The depicted NADP model is derived from a FabG1 (PDB entry 3sj7 ) ligand-bound crystal structure. |
![[Figure 2]](no5061fig2.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
