Figure 1
(a) Structure of P131 and other cpIMPDH inhibitors. The numbering scheme is shown in italics. (b) 2mFo − DFc electron-density map for P131 contoured at the 1σ level. The inhibitor is shown in ball-and-stick representation. (c) Structure of the CpIMPDH tetramer. Subunit A is in tan, subunit B is in light blue, subunit C is in pink and subunit D is in light green. IMP and P131 are shown as spheres with the following color coding: carbon, cyan for IMP and magenta for P131; oxygen, red; nitrogen, blue; phosphorus, orange; chlorine, green. (d) Superposition of the individual monomers. Dashed lines indicate disordered regions. This figure was produced with UCSF Chimera (Pettersen et al., 2004). |