 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
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![[Figure 5]](hv5284fig5mag.jpg)
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Figure 5
A schematic presentation of the roles of different actin regulators in the context of apicomplexan actin filaments. The green colour in the actin filaments indicates ATP-rich filaments and the red colour represents ADP-rich filaments. At the ATP-rich end, profilin sequesters ATP–actin monomers and provides them to formins (most likely formin 2), while CP caps growing filaments and coronin stabilizes short, newly formed filaments. In the middle region, coronin and formins bind filaments and possibly cross-link or bundle them into larger assemblies. At the ADP-rich end, ADF1 accelerates depolymerization and promotes nucleotide exchange on the monomers. CAP accelerates nucleotide exchange and sequesters actin monomers. Free ADP–actin monomers removed from the pointed end or having gone through spontaneous ATP hydrolysis in the monomeric state assemble into short oligomeric structures. It is not clear whether these oligomers are helical or linear polymers. |
![[Figure 5]](hv5284fig5.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
