Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein–protein interactions

Kumar, S.; Krishnamoorthy, K.; Mudeppa, D.G.; Rathod, P.K.

doi:10.1107/S2053230X1500549X

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 7
Intersubunit inhibitory interactions. (a) Unique, parasite-specific, interdimer contacts involving the potentially inhibitory insertion of a loop from one dimer (green) and the active site of an adjacent dimer (pink). (b) Details of the interdimer contacts showing hydrogen-bond interactions that stabilize the incoming loop (green) and that help to form a defined structure on the open `hood' (Glu85, Phe86 and Ile87).

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 71| Part 5| April 2015| Pages 600-608

doi:10.1107/S2053230X1500549X

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