Figure 4
Comparison of fragment-binding modes to known NMT ligands. (a) Fragment 2 (C atoms in slate) overlaid with a pyrazole sulfonamide ligand (C atoms in grey) bound to LmNMT (PDB entry 2wsa
). (b) Fragment 4 (C atoms in gold) overlaid with a pyridinylindole ligand (C atoms in grey) bound to LmNMT (PDB entry 4cgn
). (c) Side-chain movement of Tyr217 in the complexes with fragment 4 (C atoms in gold) and fragment 2 (C atoms in slate). |