Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form

Baum, B.; Lecker, L.S.M.; Zoltner, M.; Jaenicke, E.; Schnell, R.; Hunter, W.N.; Brenk, R.

doi:10.1107/S2053230X15010614

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 2
Overview of the apo crystal structure. (a) Secondary-structure elements of the PaFabF subunit. Helices are displayed in green and strands in yellow. Secondary-structure elements and the N-terminus and C-terminus are labelled. The buried potassium ion is shown as a brown sphere. (b) Dimer of PaFabF. The monomers are displayed in green/yellow and red/blue colour combinations. The potassium ions are shown as brown spheres and the C- and N-termini are labelled.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 71| Part 8| August 2015| Pages 1020-1026

https://doi.org/10.1107/S2053230X15010614

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