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Figure 5
Binding of compound 1. (a) Three symmetry-related subunits shown as different coloured ribbons (light blue, magenta and cyan) around the binding site of compound 1 (shown as sticks with C atoms in green). (b) The OMIT difference Fo − Fc density (green chicken wire, 1σ level) for compound 1 and a magnesium ion (green sphere). (b) View of the binding site of compound 1, with amino acids shown as sticks and the same colour code as in (a). Selected residues are labelled. The carboxylic group forms interactions with the magnesium ion and surrounding water molecules. |
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