Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form

Baum, B.; Lecker, L.S.M.; Zoltner, M.; Jaenicke, E.; Schnell, R.; Hunter, W.N.; Brenk, R.

doi:10.1107/S2053230X15010614

Acta Crystallographica Section F
Acta Crystallographica
Section F STRUCTURAL BIOLOGY COMMUNICATIONS

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Figure 5
Binding of compound 1. (a) Three symmetry-related subunits shown as different coloured ribbons (light blue, magenta and cyan) around the binding site of compound 1 (shown as sticks with C atoms in green). (b) The OMIT difference F_o − F_c density (green chicken wire, 1σ level) for compound 1 and a magnesium ion (green sphere). (b) View of the binding site of compound 1, with amino acids shown as sticks and the same colour code as in (a). Selected residues are labelled. The carboxylic group forms interactions with the magnesium ion and surrounding water molecules.

STRUCTURAL BIOLOGY
COMMUNICATIONS

ISSN: 2053-230X

Volume 71| Part 8| August 2015| Pages 1020-1026

https://doi.org/10.1107/S2053230X15010614

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