Figure 2
Crystal structure of human Spt16 NTD. (a, b) Structure of human Spt16 NTD in two orientations. The domain consists of an N-terminal lobe (residues 1–175, blue) and a C-terminal lobe (residues 176–432, light blue). (c, d) Superimposition of human (blue), S. cerevisiae (green; PDB entry 3bip
) and S. pombe (orange; PDB entry 3cb5
) Spt16 NTD structures. (c) and (d) are displayed in the same orientations as (a) and (b), respectively. Arrows indicate variations in the loops owing to differences in protein sequence and length. |