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Figure 1
Stereo image of the cisplatin coordination to His15. A platinum ion is bound to both the Nδ and N sides of the imidazole ring with ligands (two ammines and one Cl atom at Ptδ, and one chlorine, one ammine and the Arg14 side chain at Pt). Electron-density maps: 2FoFc (in blue at 1.0 r.m.s.), FoFc (in green at 5.0σ) and anomalous difference Fourier map (in orange at 3.0σ) of the final model. The two platinum ions are depicted in purple, the Cl atoms in brown, the N atoms in blue, O atoms in red and H atoms in charcoal grey. The orientation of each ammine's three H atoms and of the Arg14 side-chain H atoms at 1.7 Å diffraction resolution are obviously approximate (the Arg14 side-chain nitrogen closest to the Pt in particular would present a lone pair of electrons to the metal atom). This figure was prepared using CCP4mg (McNicholas et al., 2011BB5).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 72| Part 3| March 2016| Pages 253-254
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