Figure 3
Terminal modifications. Each Fab–peptide complex was superimposed and is shown in stereo with the corresponding SPR trace. (a) Long meditope, (b) amidated, (c) acetylated and amidated complexes. In each case the disulfide packs against Val9 and Ile10 of the light chain. Eliminating charge in each case did not produce substantial structural differences, but did improve the overall affinity. |