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Figure 2
The overall structure of the PAS domain from hEAG. (a) Cartoon representation of the crystal structure of the hEAG N-PAS domain. Six copies are found in the crystal structure. (b) Superposition of PAS domains from hEAG and mEAG (PDB entry 4hoi). The hEAG N-PAS domain is shown in green and the mEAG N-PAS domain is shown in yellow. (c) Multiple sequence alignment and secondary structures of EAG PAS domains from human, mouse, fruit fly and zebrafish. The red boxes mark residues that are highly conserved. |