 | Acta Crystallographica Section F Acta Crystallographica Section F STRUCTURAL BIOLOGY COMMUNICATIONS |
journal menu
![[Figure 2]](tt5093fig2mag.jpg)
|
|
Figure 2
Comparison of NS5 structures from ZIKV (PDB entry 5tfr), JEV (PDB entry 4k6m) and DENV3 (PDB entry 5ccv). (a) Overlay of the full-length ZIKV-NS5 structure with the JEV-NS5 structure (PDB entry 4k6m). The JEV-NS5 protein is shown in gray. The ZIKV-NS5 protein is shown in teal (MTase domain) and green (RdRp domain). The inset shows the linker regions of the two proteins (blue, ZIKV-NS5; gray, JEV-NS5). (b) Overlay of the DENV3-NS5 structure with the ZIKV-NS5 protein. The DENV3-NS5 protein is shown in red (MTase domain) and orange (RdRp domain). The ZIKV-NS5 protein is shown as in (a). (c) Sequence homology between the ZIKV-NS5 and JEV-NS5 proteins is shown by highlighting the conserved residues between the two proteins in green on the ZIKV-NS5 structure. (d) Structural overlay of the ZIKV-NS5 and JEV-NS5 proteins at the interface between the MTase and RdRp domains with conserved residues involved in the interaction. |
![[Figure 2]](tt5093fig2.jpg)
| STRUCTURAL BIOLOGY COMMUNICATIONS |
ISSN: 2053-230X
access
