Figure 1
Structure of CD27. (a) Superposition of CD27 from the present structure on the TNFR1 structure (PDB entry 1ext). CRDs are shown in different colors and TNFR1 is in gray. Disulfides (green) and N-glycosylation at Asn75 (magenta) are shown as sticks. (b) CD27 ECD with the putative CD70 epitope (residues 57–68) shown as sticks. Mutation of Arg58 leads to immunodeficiency. |