Figure 5
Fab 12E1 and Fab 10C3 CDRs. Top views of the Fab 12E1 (a) and Fab 10C3 (b) CDR regions, coloured according either to the most represented residues (left) or to the electrostatic potential distribution (right). Orange patches indicate aromatic residues (Trp and Tyr), blue patches indicate positively charged residues (Lys and Arg) and green patches indicate polar uncharged residues (Ser, Thr and Asn). Dotted black lines separate the Fab heavy and light chains. The electrostatic potential distribution was calculated with APBS (Lerner & Carlson, 2006), where red and blue surfaces show negative and positive charges contoured in the range from −3kBT e−1 (red) to +3kBT e−1 (blue), while white surfaces indicate neutral potential. |