Figure 1
(a) Meditope-binding site in the cetuximab Fab. The light chain is shown in light blue, the heavy chain in dark blue and the meditope is shown in yellow; Arg8 is highlighted in green. (b) Stereo image of the back side of the cetuximab Fab with meditope residues shown as yellow and green sticks. (c) The structure of the aminoheptanoic acid (AHA)-linked meditope (Bzymek, Ma et al., 2016); modifications of NH2 of the guanidinium group of Arg8 (highlighted in green) are the subject of this report. |