view article
Figure 4
Modifications of the methyl group of n-butyl Arg8 shown in stereo. The AHA-linked meditope is shown in yellow. Corresponding SPR traces are shown on the right. (a) No productive interactions are observed upon modification with an amine. (b) Replacing the n-butyl methyl group with a hydroxyl Arg8 (cyan) results in coordination of a water molecule (red sphere) and decreases the off-rate. (c) A carboxyethyl modification (light red) of Arg8 appears in multiple conformations, one of which is involved in similar interactions to the hydroxypropyl extension, whereas the second points away from the Fab and towards the meditope backbone.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 73| Part 12| December 2017| Pages 688-694
https://doi.org/10.1107/S2053230X17016272
Follow Acta Cryst. F
Sign up for e-alerts
E-alerts
Follow Acta Cryst. on Twitter
Twitter
Follow us on facebook
Facebook
Sign up for RSS feeds
RSS