Figure 5
Protein–protein interfaces involved in NP oligomerization and RNA binding. (a) RNA binds between the NP N- and C-terminal lobes of the folded core and is mediated by several basic amino acids as well as by the formation of hydrophobic surfaces for nucleotide base stacking. (b) Turn-on-turn interactions between NP are minimal and there are large gaps between helical turns. (c–f) NP protein–protein interactions are spread across side-to-side interactions (d), the N-terminal oligomerization region (e) and the C-terminal oligomerization region (f). |