Figure 2
(a) The active site of native neprilysin, with zinc represented as a silver sphere coordinated to His584, His588, Glu647 and phosphate ion. (b) Active site of neprilysin bound to phosphoramidon. The His584, His588 and Glu647 coordinations of Zn2+ are omitted for clarity. (c) Active site of the thiorphan complex. Ligand-omit Fo − Fc density maps are contoured at 3σ (green). |